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Glossary Dutasteride

medication that inhibits DHT to treat enlarged prostate and hair loss

Dutasteride, also known by the brand name Avodart, is a medication primarily used to treat benign prostatic hyperplasia (BPH), which is an enlarged prostate. It works by inhibiting the action of the enzyme 5-alpha-reductase, which converts testosterone to dihydrotestosterone (DHT), a hormone that contributes to prostate growth. Additionally, dutasteride is sometimes used off-label to treat male pattern baldness due to its ability to reduce DHT levels, which are implicated in hair loss.

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learn Dutasteride

Heavy duty finasteride that comes with higher risks

Can I use dutasteride without a prescription? All about its sale and regulations. Dutasteride requires a prescription and cannot be used without medical supervision.
Will I notice changes in my body if I start taking dutasteride? Dutasteride lowers DHT, so labels and trials describe prostate shrinkage over 3-6 months and, off-label, slowed hair loss; the same sources list sexual side effects and an observational link to depression.
Dutasteride: What if I just want to grow back some hair without taking pills every day? There is no approved topical dutasteride; it exists only as pharmacy-compounded preparations and small studies, so its effectiveness and long-term safety are not established.
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learn Fluridil

a topical anti-androgen with less systemic involvement

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn dehydroepiandrosterone

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community Duasteride and breast tissue accumulation.

4 upvotes 6 months ago

The user is experiencing breast tissue growth from taking dutasteride and minoxidil, and is considering reducing the dosage or stopping the medication. Suggestions include seeing an endocrinologist, using Raloxifene or Arimidex, and considering topical treatments or surgery if necessary.

community Why you may be taking Dutasteride wrong

86 upvotes 10 months ago

Dutasteride is more effective than finasteride for hair loss, with optimal dosing at 0.5mg once or twice a week to minimize side effects. Topical application may further reduce side effects while effectively lowering scalp DHT.

community Is finasteride better than dutasteride?

in Finasteride/Dutasteride 31 upvotes 1 year ago

Dutasteride reduces DHT more effectively than finasteride, but finasteride is more commonly used and approved for hair loss. Users have mixed opinions on dutasteride's effectiveness, with some experiencing better results and others facing side effects or no improvement.

community Dutasteride 0.5mg every 5 days

in Finasteride/Dutasteride 2 upvotes 1 year ago

The user is using 5% Minoxidil and 0.1% topical Finasteride and is considering adding 0.5mg Dutasteride every 5 days to stabilize hair regrowth. Consistency with treatment is advised, and there is no strong evidence linking Finasteride or Dutasteride to fertility issues.

community Dutasteride 6 months - Should I quit or wait more?

in Finasteride/Dutasteride 11 upvotes 3 years ago

The user has been on dutasteride for 6 months, experiencing initial hair health but then shedding and brittle hair, with no improvement. They use minoxidil, ketoconazole, dutasteride, and vitamin D, and are questioning whether to continue treatment despite no results.

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Research

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research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations , May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The importance of dual 5α-reductase inhibition in the treatment of male pattern hair loss: Results of a randomized placebo-controlled study of dutasteride versus finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

This study found that dutasteride increased scalp hair growth in men with male pattern hair loss, particularly at a 2.5 mg dose, and was more effective than finasteride over 24 weeks.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

research A randomized, active- and placebo-controlled study of the efficacy and safety of different doses of dutasteride versus placebo and finasteride in the treatment of male subjects with androgenetic alopecia

97 citations , January 2014 in “Journal of The American Academy of Dermatology”

This study found that dutasteride increased hair growth and restoration in men with androgenetic alopecia more effectively than finasteride and was well tolerated over 24 weeks.

Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

research Efficacy, safety, and tolerability of dutasteride 0.5 mg once daily in male patients with male pattern hair loss: A randomized, double-blind, placebo-controlled, phase III study

92 citations , June 2010 in “Journal of The American Academy of Dermatology”

This study found that 0.5 mg of dutasteride significantly improved hair growth compared to placebo and was well tolerated over six months in men with male pattern hair loss.

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