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research IL-17 axis is a significant driver of skin inflammation in Card14 mutant pityriasis rubra pilaris model mice

February 2023 in “Research Square (Research Square)”

This study reports that a new mouse model with a CARD14 mutation successfully mimics key human PRP symptoms, and anti-IL-17A antibody significantly reduces these symptoms.

research 328 The transcription factor CEBPB is a novel hub gene and multi-functional disease driver in Psoriatic skin inflammation

November 2022 in “Journal of Investigative Dermatology”

This study provides evidence that ILC1-like cells can induce alopecia areata in previously healthy human hair follicles, challenging the view that it is solely an autoantigen-dependent autoimmune disease.

research Chemotherapy of psoriasis and other skin disorders with oral retinoids

31 citations , January 1981 in “Pharmacology & Therapeutics”

In this study, 13-cis-5S*,8S*-epidioxy-5,8-dihydroretinoic acid was found to be significantly more cytotoxic to cancer cell lines than other retinoic acid analogs evaluated.

research The Physicochemical, Biopharmaceutical, and In Vitro Efficacy Properties of Freeze-Dried Dexamethasone-Loaded Lipomers

7 citations , August 2021 in “Pharmaceutics”

This study explored the use of dexamethasone-loaded polymer hybrid nanoparticles in a xanthan gum hydrogel for treating alopecia areata, finding that freeze drying with sucrose influenced particle size, release, and permeation, but had no impact on cytotoxicity or anti-inflammatory efficacy in human keratinocytes.

research Review paper The use of reflectance confocal microscopy in selected inflammatory skin diseases

20 citations , January 2015 in “Polish Journal of Pathology”

Reflectance confocal microscopy is a useful, non-invasive tool for diagnosing some skin diseases, with potential for future improvements.

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Community Join

5 / 543 results

community Scalp feels worse than ever, dried skin, inflammation or perhaps plaque?

4 upvotes 1 month ago

The conversation discusses a user's worsening scalp condition, possibly seborrheic dermatitis, despite using keto shampoo. Suggestions include using MCT C8 oil, adjusting diet by reducing carbs and sugars, and consulting a dermatologist.

community Dutasteride is working very fast

6 upvotes 2 days ago

Dutasteride is causing rapid changes in skin oiliness, leading to a switch in skincare routine. Users discuss its effects on hair and skin, with some experiencing drier hair.

community Anyone on Dutasteride have reduced scalp oil?

in Finasteride/Dutasteride 13 upvotes 1 year ago

Dutasteride may reduce scalp oil and itchiness more effectively than finasteride, with some users experiencing drier skin and improved hair thickness. Users report varying results, with some noticing benefits after switching from finasteride to dutasteride, while others use a combination of treatments including minoxidil.

community 2 year progress with Dut after a decade of Fin

154 upvotes 4 months ago

A user shared their hair loss journey, using finasteride since age 18 and adding dutasteride at 30, which halted hair loss and promoted regrowth. They take finasteride daily and dutasteride three times a week, experiencing reduced libido and drier skin as side effects.

community Topical minoxidil on scalp causing dry skin on face?

5 upvotes 5 months ago

The user started using 5% liquid minoxidil on their scalp and noticed increased facial dryness and faster facial hair growth. They plan to reduce the application to once a day to see if it helps with the dryness.

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Learn

1 / 801 results

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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