March 2026 in “Mendeley Data” This study found that human dermal papilla cells are embedded in a basement membrane-like extracellular matrix, which is essential for their aggregation and function, as supported by evidence that Matrigel enhances dermal papilla cohesion and gene expression compared to collagen I, which promotes cell dispersion.
June 1967 in “Journal of Cellular Physiology” This study developed an in vitro 3D organoid model using dermal papilla spheroids and found that it enhances growth factor expression and extracellular matrix production, which could aid drug screening for hair regeneration.
12 citations
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January 2018 in “Biomaterials Science” This study observed that dermal papilla cell aggregates showed increased viability and gene expression on softer 3D substrates, indicating the importance of substrate stiffness in cellular behavior.
April 2021 in “Journal of Investigative Dermatology” This study identified a unique transcriptional signature in occipital hair follicles that may protect them from miniaturization in androgenetic alopecia, using an animal-free model to investigate gene roles.
44 citations
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June 2018 in “Journal of Cellular Physiology” This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.