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research Molecular Docking Studies and ADME Prediction of Novel Isatin Analogs with Potent Anti-EGFR Activity

15 citations , January 2014 in “Medicinal chemistry”

This study conducted molecular docking and ADME property analysis on 144 newly designed isatin analogs, suggesting they exhibit lead-like properties for targeting EGFR enzymes.

research Molecular docking studies and ADME-Tox prediction of phytocompounds from Merremia peltata as a potential anti-alopecia treatment

7 citations , April 2021 in “Journal of advanced pharmaceutical technology & research”

This study reported that compound 16 (olean-12-en-3beta-ol, cinnamate) from Merremia peltata showed potential as an androgen receptor antagonist, suggesting it may benefit alopecia treatment based on molecular docking and ADME-Tox predictions.

research Caffeine docking studies with keratin: Implications for its cosmetic applications

2 citations , January 2022 in “Materials today: proceedings”

This study suggests that caffeine may enhance hair growth and be beneficial for cosmetic applications due to its high binding affinity to keratin, but further validation is needed.

research Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Lycopersicon esculentum mill. as a Drug Candidate for Alopecia Treatment

March 2026 in “Jurnal Pharmascience”

This study found that isorhamnetin, a compound from the Rampai plant, showed a lower affinity energy in molecular docking tests compared to Minoxidil, indicating potential as an androgen receptor antagonist for alopecia therapy in silico, with favorable pharmacokinetic characteristics in ADME-Tox predictions.

Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Punica Granatum Peel as a Potential Anti-Alopecia Treatment

research Molecular Docking Studies and ADME-Tox Prediction of Phytocompounds from Punica granatum Peel as a Potential Anti-Alopecia Treatment

May 2024 in “EAS Journal of Pharmacy and Pharmacology”

In this study, researchers used molecular docking to show that compounds from pomegranate peels, such as apigenin, luteolin, and taxifolin, effectively inhibit the enzyme 5α-reductase, suggesting potential anti-alopecic properties.

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5 / 13 results

community What's realistically the earliest pp405 becomes commercially available?

5 upvotes 10 months ago

The earliest pp405 might become available is likely between 2027 and 2030, with some users suggesting it could be as late as 2035. Current treatments mentioned include dutasteride and minoxidil.

community Would I be able to just take fin forever?

in Finasteride/Dutasteride 64 upvotes 1 year ago

An 18-year-old started taking 1mg of finasteride daily to address receding temples and is concerned about whether they will need to increase the dose or switch to dutasteride in the future. Users discuss that finasteride can slow hair loss for many years, but it is not a permanent solution, and individual responses vary.

community Breezula phase 3 results said to be released next month

26 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

484 upvotes 2 years ago

Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Why do we get bald from evolutionary perspective

in Chat 213 upvotes 1 year ago

Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

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