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research A Mutation of the Androgen Receptor Associated with Partial Androgen Resistance, Familial Gynecomastia, and Fertility

67 citations, April 1988 in “The Journal of Clinical Endocrinology & Metabolism”

A subtle androgen receptor abnormality can allow normal male development and sometimes fertility despite partial androgen resistance.

research Intermolecular NH2-/Carboxyl-Terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

227 citations, January 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

474 citations, January 2012 in “Chemistry & biology”

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

research Baiting Proteins with C60

106 citations, April 2010 in “ACS Nano”

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

research Cell Surface B2m-Free Human Leukocyte Antigen Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations, July 2023 in “Biomolecules”

B2m-free HLA variants may be a new class of HLA important in immune responses and diseases.

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community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 month ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 1 year ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community About 1 year of fin and min. To everybody who told me to get on fin, thank you. You saved my mental health. ❤

in Progress Pictures 657 upvotes 2 years ago

User shared 1-year progress using finasteride and minoxidil, thanking others for the recommendation. Many congratulated the user, while some asked about dosages and shared their own experiences with the treatments.

community Binding affinity of pyrilutamide!

in Update 168 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

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