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research Intermolecular NH2-/Carboxyl-Terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

227 citations, January 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

research Baiting Proteins with C60

106 citations, April 2010 in “ACS Nano”

C60 fullerenes can alter protein function and may help develop new disease inhibitors.

Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

research Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

November 2023 in “Advanced Science”

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

research Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

50 citations, September 2016 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

research Fidelity of the Human Mitochondrial DNA Polymerase

101 citations, September 2006 in “Journal of Biological Chemistry”

Human mitochondrial DNA polymerase makes very few errors, crucial for preventing degenerative diseases.

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community A systematic bro-science review of DHT, 5AR, neurosteroids, sexual health and 5AR inhibitors

rhguven in Research/Science 37 upvotes 2 years ago

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

PlayfulGarage8573 in Finasteride/Dutasteride 13 upvotes 3 months ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Why is Kevin Mann (Haircafe) Hated?

withasociety in Chat 62 upvotes 1 year ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community Binding affinity of pyrilutamide!

alexffy66433 in Update 171 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community About 1 year of fin and min. To everybody who told me to get on fin, thank you. You saved my mental health. ❤

ProfessionalLeader75 in Progress Pictures 657 upvotes 3 years ago

User shared 1-year progress using finasteride and minoxidil, thanking others for the recommendation. Many congratulated the user, while some asked about dosages and shared their own experiences with the treatments.

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