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research Intermolecular NH2-/Carboxyl-Terminal Interactions in Androgen Receptor Dimerization Revealed by Mutations That Cause Androgen Insensitivity

227 citations, January 1998 in “Journal of biological chemistry/The Journal of biological chemistry”

Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

research Non-Canonical Dimerization of the Androgen Receptor and Other Nuclear Receptors: Implications for Human Disease

25 citations, June 2019 in “Endocrine Related Cancer”

Mutations in certain receptors can cause diseases and offer new treatment options.

research Allosteric Interactions Prime Androgen Receptor Dimerization And Activation

1 citations, February 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.

research Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization

24 citations, July 2017 in “Structure”

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

research The Emerging Structural Pharmacology of ATP-Sensitive Potassium Channels

5 citations, September 2022 in “Molecular pharmacology”

KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.

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community HLT Megathread on HMI-115 (key takeaways in comments)

in Research/Science 39 upvotes 1 year ago

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.