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Mutations at Val-889 and Arg-752 disrupt key interactions in the androgen receptor, affecting its function.

Mutations in certain receptors can cause diseases and offer new treatment options.

Certain interactions help prepare the androgen receptor for pairing and activation, which is important for its role in development and disease.

FGF9 controls which receptors it binds to through a process where two FGF9 molecules join, and changes in FGF9 can lead to incorrect receptor activation.

KATP channels are important for energy balance and are targeted by drugs for diabetes, hypoglycemia, hypertension, and hair loss.

Finding functions for unknown GPCRs is hard but key for making new drugs.

Testosterone is crucial for development, growth, and various body functions in mammals.

Mutations in the androgen receptor gene cause different levels of androgen insensitivity, making it hard to create simple tests for the condition.

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

Activin helps skin growth and healing mainly through stromal cells and affects keratinocytes based on its amount.

Cetuximab can cause excessive eyelash growth.

IGF-1 may affect hair growth and loss, but more research is needed to confirm effective and safe treatments.

SCF and ET-1 together significantly increase skin pigmentation and melanin production.

ISCK03 stops melanin production in human melanoma cells and lightens skin color in mice and guinea pigs.

A mutation in the KRT71 gene causes a hair disorder by disrupting hair follicle structure and texture.

A new gene mutation may allow some piebaldism patients to regain skin color in white patches.

Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.

The E2 protein affects gene activity in hair follicles of mice.

Different substances that activate or block the androgen receptor can affect male development and treat conditions like prostate cancer.

Sex steroids affect the MafB gene differently in male and female hamsters.

New drugs targeting the JAK-STAT pathway show promise for treating inflammatory skin diseases.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

The PDGF/PDGFR pathway is a potential drug target with mixed success in treating various diseases, including some cancers and fibrosis.