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community Desensitize Follicle Sensitivity to DHT?

12 upvotes 1 month ago

Hair follicles cannot be desensitized to DHT like allergies; treatments focus on reducing DHT levels or blocking its effects using methods like finasteride, GT20029, or PROTACs. Topical treatments like ceterizine and BPA application are also mentioned.

community If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit?

13 upvotes 4 years ago

The conversation discusses the effectiveness of reducing DHT for hair loss treatment and explores alternative approaches like reducing androgen receptor sensitivity. Specific treatments mentioned include finasteride, dutasteride, pyrilutamide (KX-826), GT20029, and RU58841.

community How does testosterone and dht work?

14 upvotes 1 month ago

Hair loss is influenced by follicle sensitivity to DHT, which increases with age, rather than just testosterone levels. Treatments like finasteride and hair transplants are used to manage hair loss, with transplants needing medication to protect surrounding sensitive hair.

community Is DHT actually the cause of male pattern hair loss or just a correlating factor? Why I think the research is more complicated than we're told and why I've been looking into GHK-Cu

78 upvotes 4 months ago

DHT is not the only cause of male pattern hair loss; genetic sensitivity, inflammation, and fibrosis also contribute. GHK-Cu, a copper peptide, is being explored as an alternative treatment to finasteride and minoxidil, showing potential in improving follicle health.

community Creatine effects on DHT Experiment

57 upvotes 2 years ago

Creatine might increase hair loss due to increased DHT sensitivity, but evidence is mostly anecdotal. The user is using oral minoxidil for hair loss and is cautious about starting creatine.

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Research

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research Hedonic sensitivity to natural rewards is affected by prenatal stress in a sex-dependent manner

28 citations , May 2015 in “Addiction Biology”

This study found that early life stress significantly affects hedonic sensitivity to high-palatable food by altering gonadal hormones in prenatally-stressed male and female rats, with sex-dependent changes in reward-related behaviors and neurochemistry.

research Ageing skin, part 1: normal ageing

3 citations , May 2011 in “Practice nursing”

As skin ages, it gets thinner, paler, and more wrinkled, and protection and care like sunblock and moisturizers are important.

research Androgen Receptor Gene Polymorphism and Prostate Zonal Volumes in Australian and Chinese Men

34 citations , January 2000 in “Journal of Andrology”

This study found no difference in CAG repeat length between Chinese and Australian men, refuting the hypothesis that this polymorphism and central prostate zone volume are markers of long-term androgen sensitivity.

research Finasteride-its impact on sexual function and prostate cancer

33 citations , January 2009 in “Journal of Cutaneous and Aesthetic Surgery”

This study found no clear evidence that finasteride negatively affects erectile function, though it does cause a reduction in ejaculatory volume and has potential implications for prostate cancer risk.

research 5 Dihydrotestosterone metabolism

22 citations , May 1986 in “Clinics in endocrinology and metabolism”

This study found that women with lower 2D:4D ratios and fewer middle-phalangeal hairs reported more adverse side effects from oral contraceptives, suggesting these features may predict hormonal contraceptive side effects.

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Learn

6 / 19 results

learn Hair Transplant

What causes male pattern baldness? Male pattern baldness is caused by genetic sensitivity to the hormone DHT.

learn Bicalutamide

Nonsteroidal anti-androgen, originally a prostate cancer drug

Can bicalutamide stop DHT from shrinking your hair follicles? Bicalutamide blocks androgens at the receptor rather than lowering DHT, and some dermatologists prescribe it off-label for women with pattern hair loss, although its US label says it should not be used in women. The one randomised trial (74 women, 2025) found it added no benefit to oral minoxidil, and the drug needs liver monitoring because its label warns of severe and fatal liver injury; it is contraindicated in pregnancy.

learn Neem Oil

Oil from the neem tree, used in traditional remedies

learn procapil

Does Procapil block DHT without affecting hormones? What the evidence shows Procapil's supplier describes it as inhibiting 5-alpha reductase at the scalp without changing hormone levels, but the published support is cell and animal work plus one small human study of a caffeine-plus-Procapil formula. It is a cosmetic ingredient, not an approved hair-loss treatment, and no trial has compared it with finasteride or minoxidil.

learn Baicapil

Does Baicapil block DHT? What the evidence shows No published study shows that Baicapil blocks DHT — the only data on the ingredient itself is the manufacturer's own unpublished dossier, and the baicalin research behind the claim is prostate cancer cell-line work that did not measure DHT or hair.

learn Metformin

Does metformin help control DHT levels that trigger androgenic alopecia? Small studies have found that metformin lowers circulating androgens in women with PCOS, but no published study has measured scalp DHT, 5-alpha reductase activity in the follicle, or hair density in anyone taking it — so its effect on pattern hair loss is untested, and it is not a DHT blocker.

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Clinics

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