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GlossaryDiacylglycerol O-Acyltransferase 1 (DGAT-1)

enzyme that catalyzes the final step in triglyceride synthesis

Diacylglycerol O-Acyltransferase 1 (DGAT1) is an enzyme that plays a crucial role in the body's ability to store fat. It catalyzes the final step in the synthesis of triglycerides, which are the main form of stored energy in fat cells. This enzyme is important for energy metabolism and has been studied for its potential links to obesity and metabolic disorders.

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research The Triacylglycerol Synthesis Enzyme DGAT1 Also Catalyzes the Synthesis of Diacylglycerols, Waxes, and Retinyl Esters

258 citations , July 2005 in “Journal of lipid research”

DGAT1 enzyme helps make diacylglycerols, waxes, and retinyl esters.

research Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin

91 citations , November 2008 in “Journal of biological chemistry/The Journal of biological chemistry”

DGAT1 enzyme is crucial for healthy skin and hair by regulating retinoid levels.

Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

research Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

6 citations , August 2014 in “Toxicologic pathology”

Blocking DGAT1 reduces oil gland size in mice and dogs, but only mice experience hair loss.

research DGAT1 Modulates Hair Cycling and Is Essential for Retinoid Homeostasis in the Skin

June 2007

The enzyme Dgat1 is essential for healthy hair and skin by controlling retinoid levels.

research MEK and BRAF Inhibitors Augment the Production and Accumulation of Sebum in Hamster Sebocytes

April 2016 in “Journal of Investigative Dermatology”

MEK and BRAF inhibitors increase sebum production and accumulation, which could cause acne-like side effects.

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