research A Systematic Review on Clinical Evidence for Topical Metformin: Old Medication With New Application
This systematic review evaluates the clinical evidence for the use of topical metformin, traditionally an oral diabetes medication, in various human studies. A total of 30 articles were reviewed, focusing on its application in dentistry and dermatology. In dentistry, topical metformin has been effective in treating periodontitis, enhancing the benefits of platelet-rich fibrin for furcation-involved teeth, and improving osseointegration when used on dental implants. In dermatology, results for melasma treatment were inconsistent, but topical metformin showed promise in promoting hair regrowth, wound healing, and treating acne vulgaris, indicating its potential as a treatment option for these conditions.