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research A novel regio-specific cyclosporin hydroxylase gene revealed through the genome mining of Pseudonocardia autotrophica

3 citations , March 2014 in “Journal of Industrial Microbiology & Biotechnology”

This study identified a cytochrome P450 enzyme, CYP-pa1 from Pseudonocardia autotrophica, as responsible for the specific hydroxylation of cyclosporin A at the 9th N-methyl leucine, suggesting potential for biotechnological applications.

research Structure-guided manipulation of the regioselectivity of the cyclosporine A hydroxylase CYP-sb21 from Sebekia benihana

3 citations , July 2020 in “Synthetic and Systems Biotechnology”

This study found that the cytochrome P450 enzyme CYP-sb21 can hydroxylate cyclosporine A at multiple positions, reducing its immunosuppressive effects but retaining its hair growth-promoting side-effect, and suggests modifications to improve regioselectivity for commercial use.

research Physiological perspective of Hirsutism in Unani Medicine: An Overview and Update

2 citations , August 2013 in “International Journal of Herbal Medicine”

This review discusses the historical concepts of hirsutism in Unani Medicine and evaluates herbal treatments, indicating these may influence underlying endocrine issues but current evidence remains insufficient.

research Anti-inflammatory Effects in LPS-treated RAW 264.7 Cells and the Influences on Drug Metabolizing Enzyme Activities by the Traditional Herbal Formulas, Yongdamsagan-Tang and Paljung-san

December 2021 in “Daehanhanuihakoeji”

This study suggests that combining finasteride with traditional herbal formulas Yongdamsagan-tang or Paljung-san may not interfere with drug metabolism while potentially enhancing anti-inflammatory effects for treating benign prostatic hyperplasia.

research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles

September 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, the reconstructed skin epidermal model derived from hair follicles showed gene expression and enzyme functionality consistent with native human skin, suggesting its viability for studying skin metabolism and potential toxicity of dermo-cosmetic ingredients.

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community Dutasteride during virilization?

in Finasteride/Dutasteride 1 upvotes 8 months ago

A 22-year-old is experiencing hair loss after transitioning from fem HRT to DIY testosterone therapy and is considering using Dutasteride while also taking Saw Palmetto. They are concerned about the impact on virilization and proper development.

community people who grew hair in temples please help me

16 upvotes 1 month ago

Regrowing hair in temple areas is challenging, but some have seen success using treatments like minoxidil, finasteride, and dutasteride, often combined with other methods like scalp massage and low-level laser therapy. Younger individuals may have a better chance of regrowth, but results vary greatly among individuals.

community 2.5 years 1mg finasteride daily

4887 upvotes 8 months ago

Significant hair regrowth was achieved after 2.5 years of taking 1 mg finasteride daily, without using minoxidil or microneedling. Minor side effects included a slightly thinner beard and longer time to finish during sex.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 21 upvotes 1 year ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Oral Minoxidil and Grapefruit Juice

in Research/Science 96 upvotes 3 years ago

The conversation is about the potential dangers of taking oral minoxidil and grapefruit juice together. Some users express concern about dangerous drug interactions, while others argue that grapefruit juice may inhibit the metabolism of finasteride. The conclusion is that grapefruit juice may make finasteride less effective, but it won't affect minoxidil.

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