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    Did you mean Cyclooxygenase-2?
    Glossary Cyclooxygenase-2

    enzyme involved in inflammation and pain production

    Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in the inflammatory process by converting arachidonic acid into prostaglandins, which are compounds that mediate inflammation and pain. Unlike its counterpart COX-1, which is expressed constantly in most tissues, COX-2 is typically induced during inflammation and is a target for anti-inflammatory drugs like NSAIDs (nonsteroidal anti-inflammatory drugs).

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    Research 10 of 718

    1. Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin Proceedings of the National Academy of Sciences · 2001 · 201 citations
    2. Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development. PubMed · 2002 · 113 citations
    3. Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation International Journal of Nanomedicine · 2020 · 45 citations
    4. Expression of Cyclooxygenase Isozymes During Morphogenesis and Cycling of Pelage Hair Follicles in Mouse Skin: Precocious Onset of the First Catagen Phase and Alopecia upon Cyclooxygenase-2 Overexpression Journal of Investigative Dermatology · 2003 · 41 citations
    5. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    6. Diphlorethohydroxycarmalol, Isolated from Ishige okamurae, Increases Prostaglandin E<sub>2</sub>through the Expression of Cyclooxygenase-1 and -2 in HaCaT Human Keratinocytes Biomolecules & therapeutics · 2012 · 9 citations
    7. Expression Pattern of Cyclooxygenase-2 in Normal Rat Epidermis and Pilosebaceous Unit during Hair Cycle Acta histochemica et cytochemica · 2008 · 9 citations
    8. 919 Overexpression of cyclooxygenase-2 in the skin of adult transgenic mice leads to sebaceous gland hyperplasia and thinning of hair shafts Journal of Investigative Dermatology · 2019
    9. Re: Associations Between Variants in the Cyclooxygenase 2 Enzyme Gene (PTGS2) and Development of Benign Prostate Enlargement The Journal of Urology · 2012
    10. 607 Cutaneous overexpression of cyclooxygenase-2 models androgenetic alopecia in adult mice Journal of Investigative Dermatology · 2021
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