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GlossaryCyclooxygenase-2

enzyme involved in inflammation and pain production

Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in the inflammatory process by converting arachidonic acid into prostaglandins, which are compounds that mediate inflammation and pain. Unlike its counterpart COX-1, which is expressed constantly in most tissues, COX-2 is typically induced during inflammation and is a target for anti-inflammatory drugs like NSAIDs (nonsteroidal anti-inflammatory drugs).

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research Cyclooxygenases in the Skin: Pharmacological and Toxicological Implications

165 citations , September 2003 in “Toxicology and applied pharmacology”

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

research Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development

113 citations , May 2002 in “PubMed”

Overexpressing COX-2 in mice skin reduces skin tumor development.

research Anti-Inflammatory, Cyclooxygenase Inhibitory, and Antioxidant Activities of Standardized Extracts of Tridax Procumbens L.

61 citations , September 2010 in “Fitoterapia”

Extracts from Tridax procumbens L. have strong anti-inflammatory and antioxidant effects and block inflammation-causing enzymes.

research Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research Protein Kinase C Delta Overexpressing Transgenic Mice Are Resistant to Chemically but Not to UV Radiation-Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

35 citations , January 2006 in “Cancer Research”

Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.

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community Brotzu lotion update

in Update 90 upvotes 7 years ago

A new hair loss lotion by Dr. Brotzu, expected to regrow up to 5 years of lost hair, is set to be released by Fidia Farmaceutici. It claims to work like minoxidil and finasteride without side effects, but skepticism exists due to its classification as a cosmetic product.