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research Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.

Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

research Cytoplasmic free calcium distributions during the development of root hairs of Arabidopsis thaliana

317 citations , August 1997 in “The Plant Journal”

This study observed that while calcium influx does not initiate root hairs in Arabidopsis thaliana, it may be crucial for sustaining their elongation through elevated calcium levels at the root hair tip.

research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

297 citations , January 2002 in “Development”

In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

research Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas.

277 citations , October 1982 in “The Journal of Cell Biology”

This study found that the cytokeratin patterns in skin epithelia can distinguish between different types, with basal-cell epitheliomas showing a striking similarity to the pilosebaceous tract.

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Community Join

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community Cypro to reverse hairloss + Fin?

in Treatment 1 year ago

The conversation discusses using cyproterone temporarily to reverse hair loss, followed by finasteride to maintain regrowth. Concerns about cyproterone's side effects, such as lowering testosterone and potential health risks, are raised, with alternatives like spironolactone suggested for androgen-related issues.

community Insane Idea: Cyperus Rotundus Oil?

in Research/Science 9 upvotes 1 year ago

Cyperus rotundus oil is suggested as a natural treatment for androgenic alopecia, potentially inhibiting hair growth without affecting testosterone levels. The conversation questions its effectiveness and safety for scalp use.

community How cyproterone acetate and spironolactone come to my mind whenever I look in the mirror

in Satire 11 upvotes 9 months ago

The conversation humorously discusses hair loss treatments, mentioning spironolactone and cyproterone acetate. It reflects a sense of frustration and satire about the effectiveness of these treatments.

community The never ending cycle as a fin+min user

1356 upvotes 2 weeks ago

Hair loss treatments like finasteride and minoxidil can cause cycles of shedding and regrowth, leading to fluctuating emotions. Users experience periods of hair improvement followed by shedding, with some finding long-term stabilization elusive.

community Should I avoid a testosterone cycle if I care a lot about keeping my hair?

in Treatment 5 upvotes 3 weeks ago

Avoid testosterone cycles if you care about hair preservation, as they can accelerate hair loss despite using finasteride. Consider alternatives like dutasteride for better protection against hair loss.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

Is cyproterone only for women, or can men use it too? Cyproterone acetate is not a women-only drug — published reports describe use in men for prostate cancer, paraphilic disorders and gender-affirming therapy — but it is not FDA-approved for any indication, and European regulators restricted higher doses over a dose-related meningioma risk.
Is cyproterone safe to use during gender transition? Regulators and a large French cohort study link higher-dose, long-term cyproterone acetate to meningioma, and its label also lists liver-enzyme and mood effects — so it is not a drug anyone should call safe in the abstract, and its use in gender-affirming care is a prescriber's decision with monitoring.
How long does it take for cyproterone to work on hair loss? There is no reliable published figure for how fast cyproterone works on hair loss: the hair cycle means nothing shows for months, the one randomised trial assessed women at twelve months, and community reports range from about six months to two years — with some people seeing no change at all.
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learn Cypress Oil

learn L-cysteine

What is L-cysteine, and why is it often included in hair growth supplements? L-cysteine supports hair growth by strengthening keratin, the main protein in hair.

learn O-Cymen-5-Ol

learn acetyl cysteine

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