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research CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing

149 citations , August 2022 in “Biochemistry (Moscow)”

This review covers the history and development of CRISPR-Cas9 technology, highlighting its groundbreaking applications and the ethical concerns surrounding its use in human germline editing.

research Disruption of FGF5 in Cashmere Goats Using CRISPR/Cas9 Results in More Secondary Hair Follicles and Longer Fibers

104 citations , October 2016 in “PLoS ONE”

This study found that CRISPR/Cas9-mediated disruption of the FGF5 gene in goats increased hair follicle numbers and fiber length, suggesting more cashmere production could be achieved.

research Delivery of Tissue-Targeted Scalpels: Opportunities and Challenges for In Vivo CRISPR/Cas-Based Genome Editing

60 citations , July 2020 in “ACS Nano”

This review discusses the progress and challenges in delivering CRISPR/Cas9 systems for in vivo genome editing, highlighting current methods and opportunities for future therapeutic applications.

research Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy

47 citations , December 2019 in “Biomaterials”

This study demonstrated effective delivery of CRISPR/Cas9 components to dermal papilla cells in androgenic alopecia animals using ultrasound-activated nanoparticles, resulting in specific gene editing and hair growth recovery.

research CRISPR/Cas9‐mediated loss of FGF5 function increases wool staple length in sheep

47 citations , June 2017 in “The FEBS journal”

This study found that CRISPR/Cas9-induced loss-of-function mutations in the FGF5 gene significantly increased wool length and yield in genetically modified Chinese Merino sheep compared to wild-type controls.

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community The pessimism about the Crisp Cas 9 is excessive

12 upvotes 11 months ago

CRISPR Cas9 could potentially treat baldness by targeting specific genes in hair follicles without affecting other body functions. There is optimism about its future use, despite ethical concerns and the current reliance on treatments like minoxidil and finasteride.

community CRISPR Is Curing People Right Now. Genetic Hair Loss is Next?

112 upvotes 1 year ago

CRISPR shows promise for treating hair loss by targeting specific genes. Current treatments include Minoxidil and finasteride, but CRISPR could offer a more precise solution, though it is still expensive and in early stages.

community Why do we have head hair in first place if we evolved to start losing it in some cases as soon as puberty hits

140 upvotes 11 months ago

Hair loss is influenced by genetics and sensitivity to hormones like DHT. Treatments like Minoxidil and finasteride are commonly used, and baldness persists as it doesn't affect reproductive success.

community DHT is making fun of you, let's not suffer!

17 upvotes 11 months ago

DHT negatively affects scalp hair while promoting body hair growth, causing frustration due to the lack of permanent solutions for baldness. Users discuss treatments like finasteride and potential future solutions like CRISPR technology.

community PP405 Hair Loss Drug: Phase 1 Human Results & Biopsy Insights

213 upvotes 1 year ago

PP405 is a potential hair loss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.

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Hair Loss Treatments
Crispr Skin and Hair ClinicChennai, Tamil Nadu · IN

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