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research Common questions and misconceptions about creatine supplementation: what does the scientific evidence really show?

140 citations , January 2021 in “Journal of the International Society of Sports Nutrition”

This source reports that while creatine supplementation is popular for improving muscle mass and performance, questions about its efficacy and safety persist. An expert team is reviewing literature to address concerns like water retention, renal effects, and its benefits across different populations and uses.

research PAK4 signaling in health and disease: defining the PAK4–CREB axis

81 citations , February 2019 in “Experimental & Molecular Medicine”

This review examines PAK4 signaling pathways in prostate cancer, Parkinson's disease, and melanogenesis, focusing on the potential role of the PAK4-CREB axis, without reporting new clinical results.

Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

research Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

47 citations , September 2013 in “Aaps Pharmscitech”

This study found that liquid crystalline nanoparticles formulated with Cremophor surfactants significantly enhanced skin permeation of finasteride compared to lower surfactant concentrations.

research Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro‐collagen lipopeptide, creatine, and urea on skin aging signs

36 citations , October 2015 in “Journal of Cosmetic Dermatology”

In this study, a new apple stem cell extract serum significantly improved signs of skin aging and enhanced cell metabolism in human senescent fibroblasts, showing visible effects after one week of use.

research The crest phenotype in domestic chicken is caused by a 195 bp duplication in the intron of HOXC10

29 citations , January 2021 in “G3 Genes Genomes Genetics”

This study identified a 195 bp duplication in crested chickens that causes large crest feathers and can be associated with cerebral hernia in some breeds, but not all.

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Community Join

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community Any gym-goers on here that use creatine?

43 upvotes 5 years ago

Creatine may increase DHT levels, potentially affecting hair loss, but experiences vary. Many users use finasteride to counteract potential effects.

community Results are in for my experiment with Creatine/Fin

129 upvotes 6 years ago

Creatine use with finasteride increased DHT levels, possibly affecting hair loss. The user plans to reduce creatine to stabilize DHT and hair shedding.

community Is there hope for creating new hair follicles?

6 upvotes 2 weeks ago

Creating new hair follicles is unlikely in the next 10-20 years, with current treatments focusing on stimulating existing follicles. Experimental treatments like ky19382 are being tested, but reliable solutions are not yet available.

community Creatine and hair loss: What is the your personal experience?

1 month ago

Creatine may increase hair shedding for some, especially those sensitive to DHT, but experiences vary. Many users on finasteride and minoxidil report no additional hair loss from creatine.

community Creatine and Hair Loss: Are the studies misleading?

74 upvotes 1 month ago

Some users believe creatine may cause hair loss, citing anecdotal evidence and criticizing study flaws. Others argue there's no proven link between creatine and hair loss, suggesting any shedding might be due to other factors or genetic predisposition.

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Learn

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learn CREATINE

learn Scalp Micropigmentation

Can numbing cream be used during scalp micropigmentation? Numbing cream can be used during scalp micropigmentation, but its effects vary by provider.
When can I wear makeup after scalp micropigmentation? Avoid makeup on the treated area for 7-14 days after scalp micropigmentation.

learn Hydrocortisone

How do you safely apply hydrocortisone cream or lotion to the scalp without overusing it? The over-the-counter hydrocortisone label sets the limits: a thin film on the affected patch, no more than three or four times a day, and no longer than seven days without a doctor's direction — and the scalp absorbs corticosteroids more than most skin, so prolonged use raises the risk of thinning skin.

learn Rapamycin

Are there any visible side effects when using rapamycin cream or serum on the scalp? Visible side effects may include skin irritation or redness when using rapamycin on the scalp.

learn Centella

Got small bald circles with no warning? Centella creams might calm the area and kickstart new growth. There is no published human trial of Centella asiatica for alopecia areata or any other hair loss; the only hair-related studies are cell-culture work. Community users describe Centella creams as soothing for an irritated scalp, not as regrowth treatments, and a new bald patch needs a doctor's diagnosis first.