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research Mice with a null mutation of the TGFα gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation

578 citations , April 1993 in “Cell”

This study found that mice with a disrupted TGFα gene display a curly whisker-coat phenotype, similar to waved-1 mice, suggesting TGFα's crucial role in skin architecture and hair development.

research Measurement of cortisol in human Hair as a biomarker of systemic exposure

567 citations , October 2007 in “Clinical and investigative medicine”

This study described a new assay for measuring cortisol in hair and found it may serve as a useful biomarker for long-term cortisol exposure, correlating with 24-hour urine cortisol levels in non-obese subjects.

research Hair as a retrospective calendar of cortisol production—Increased cortisol incorporation into hair in the third trimester of pregnancy

501 citations , October 2008 in “Psychoneuroendocrinology”

This study suggests that cortisol measured in human hair can effectively reflect increased production for up to six months, but its retrospective accuracy may be limited due to rapid decline in levels.

research Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol

489 citations , June 2005 in “The FASEB Journal”

This study found that human scalp hair follicles can respond to corticotropin releasing hormone stimulation similarly to the classical HPA axis, including up-regulating cortisol production and activating neuroendocrine feedback loops.

research Epithelial barrier function: assembly and structural features of the cornified cell envelope

425 citations , August 2002 in “BioEssays”

This review discusses the structure and assembly of the cornified cell envelope in stratified squamous epithelial cells and various disorders leading to barrier defects, but reports no new findings.

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Community Join

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community No luck with meds, Check your Cortisol.

in Treatment 33 upvotes 2 years ago

Cortisol from stress can cause hair loss. Controlling cortisol levels improved the effectiveness of finasteride for hair regrowth.

community Correct way to microneedling, with existent hair

in Microneedling 12 upvotes 2 years ago

The conversation discusses the correct method of microneedling for hair loss, questioning whether it should be done on areas with long hair without risking hair damage, and if it's necessary for improving blood flow to existing hair. No specific treatments were mentioned.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community My Corrective Hair Transplant surgery update 1670 Grafts.

13 upvotes 1 month ago

A user shared progress pictures of a corrective hair transplant involving 1670 grafts after a previous unsuccessful surgery. The conversation includes questions about medication use and comments on hairline design.

community Low cortisol it is due the fin

7 upvotes 1 year ago

The user has been taking 1mg finasteride daily for a year with no improvement in hair loss and reports low cortisol levels, sleep issues, and anxiety changes. The conversation includes discussions on the potential effects of finasteride on cortisol and neurosteroids, with suggestions to consult a doctor and consider other factors.

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learn Hedychium coronarium

learn Dutasteride

Dutasteride: Correct Dosage and Administration The US label dose of dutasteride (for BPH) is 0.5 mg once daily; in Japan the approved hair-loss dose is 0.1 mg daily, increased to 0.5 mg if needed. Any dose or schedule for hair loss should be set by a prescriber.

learn Hair Fibers

How do you apply hair fibers correctly so they stay in place all day? Apply hair fibers to clean, dry hair and use a setting spray for better hold.

learn Nanoxidil

How do you use Nanoxidil correctly on the scalp for best results? Follow the directions on the product label. There is no independent evidence on the best way to use Nanoxidil or on whether it works.

learn Finasteride

Finasteride for alopecia: the definitive guide to using it correctly. Finasteride 1 mg daily blocks DHT and, in trials, slowed hair loss in most men over 6 to 12 months, though some men do not respond and the benefit lasts only while the drug is taken. It is prescription-only, carries a pregnancy contraindication, and has reported sexual, mood, breast and semen side effects, some of which men report continuing after stopping.