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Did you mean competing endogenous RNA?

Glossary competing endogenous RNA

molecules that regulate gene expression by sequestering microRNAs

Competing endogenous RNAs (ceRNAs) are molecules within cells that can regulate gene expression by "competing" for shared microRNAs. Essentially, they act like sponges, binding to microRNAs and preventing these microRNAs from attaching to their usual target messenger RNAs (mRNAs), which would otherwise inhibit the production of certain proteins. This mechanism plays a crucial role in various biological processes and diseases, including cancer and hair loss conditions like alopecia.

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research Differential expression patterns of specific long noncoding RNAs and competing endogenous RNA network in alopecia areata

10 citations , February 2019 in “Journal of Cellular Biochemistry”

This study reports a complex network of blood lncRNA and associated pathways in alopecia areata but suggests further research is needed for verification and understanding of these findings.

research Synchronous profiling and analysis of mRNAs and ncRNAs in the dermal papilla cells from cashmere goats

17 citations , June 2019 in “BMC genomics”

This study cataloged several long non-coding RNAs and microRNAs in cashmere goat dermal papilla cells, suggesting these non-coding RNAs may play a role in hair follicle stem cell activation and hair growth.

research Screening of circRNAs Associated with Secondary Wool Follicle Development in Fine-Wool Sheep and Construction of Their ceRNA Network

September 2025 in “Animals”

This study analyzed circular RNA expression in the developing skin of foetal Gansu Alpine fine-wool sheep, identifying key circRNAs potentially involved in secondary follicle development through regulatory networks, providing insights for wool trait improvement.

research Comprehensive Transcriptome Analysis of Hair Follicle Morphogenesis Reveals That lncRNA-H19 Promotes Dermal Papilla Cell Proliferation through the Chi-miR-214-3p/β-Catenin Axis in Cashmere Goats

7 citations , September 2022 in “International journal of molecular sciences”

This study identified and analyzed numerous lncRNAs, miRNAs, and mRNAs involved in hair follicle development in cashmere goats, highlighting key regulatory pathways and suggesting roles for specific RNAs in enhancing hair follicle cell proliferation.

research LncRNA-miRNA-mRNA regulatory networks in skin aging and therapeutic potentials

3 citations , October 2023 in “Frontiers in physiology”

This study reviewed competing endogenous RNA networks related to skin aging and wound healing, finding mechanisms like UVB-induced senescence and photoaging, as well as potential therapeutic targets for improving skin health and recovery.

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community 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?

27 upvotes 1 year ago

Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.

community Where do you guys get Topilutamide from? (if you even do)

in Chat 5 upvotes 4 months ago

The conversation discusses sourcing Topilutamide (fluridil) as a treatment for hair loss, with users comparing it to RU58841 and finasteride. Users share their experiences with various treatments, including testosterone, DHT gel, and Proviron, while expressing difficulty in finding Topilutamide.

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