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    Did you mean transdifferentiation?
    Glossary transdifferentiation

    mature cell changes directly into another mature cell type

    Transdifferentiation is a biological process where one type of mature cell transforms into another type of mature cell without first reverting to a stem cell state. For example, a skin cell might change directly into a nerve cell. This process is significant in regenerative medicine and tissue engineering because it offers potential for repairing damaged tissues and organs.

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      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

       3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Painkillers May Block Minoxidil

       12 upvotes 1 year ago
      Painkillers like Aspirin may reduce Minoxidil's effectiveness by inhibiting the enzyme PGHS-1, which is crucial for hair growth. Using NSAIDs that inhibit COX-2 or combining Minoxidil with PGF2/E2 analogues or retinoids may enhance its efficacy.

      community One year on finasteride has reversed some aging

      in Chat  198 upvotes 11 months ago
      Finasteride and minoxidil use resulted in a more youthful appearance and improved skin. There is debate about their effects on collagen and skin aging, with no solid evidence supporting significant changes due to finasteride.

      community DHT is about to get smashed ….

       802 upvotes 2 years ago
      The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

       737 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Trans guy with frontal hair loss - making sure I'm doing the right things.

       5 upvotes 8 years ago
      A trans man experiencing frontal hair loss is considering using finasteride and minoxidil, while also consulting a dermatologist. He is cautious about starting treatments before his appointment and is concerned about the effects of rapid weight loss on his hair.

      community 2022->2026, 3.5 years Fin, no min, trans male

       81 upvotes 2 months ago
      A trans male shared his 3.5-year experience using finasteride for hair loss, noting improvements in hair density and hairline thickness without using minoxidil due to health concerns. He also uses Tołpa Torf shampoos and scalp serums, and emphasizes the importance of mental health and self-image in his journey.

      community Dutasteride for trans men? (Topical vs oral?)

      in Transgender 1 year ago
      The conversation discusses using dutasteride, both topical and oral, for hair loss in trans men, considering potential side effects like depression and libido issues. The user is exploring options including topical solutions with minoxidil, retinoic acid, and hydrocortisone, and plans to start microneedling.

      community Is my current doseage viable? (Trans)

       3 upvotes 10 months ago
      The user is taking Dutasteride, Finasteride, Estradiol, Spironolactone, and Progesterone for hair regrowth and is considering adding Minoxidil and rosemary oil. They are experiencing some hair regrowth and are consulting a dermatologist to avoid a hair transplant.

      community progress pics (HRT, fin, min, microneedling) (35, trans non-binary)

       11 upvotes 1 year ago
      A non-binary transfeminine person experienced significant hair regrowth after starting finasteride, minoxidil, microneedling, and hormone replacement therapy with estradiol. They encourage trans individuals concerned about hair loss to consider estrogen as it has greatly improved their hair condition.

      community Why is my crown still thinning? (MTF 4+ years/Fin 3+ years/Microneedling 1mo)

       4 upvotes 3 years ago
      Trans woman experiencing thinning hair despite low testosterone and finasteride use seeks possible causes and solutions. Current treatments include finasteride, spironolactone, estradiol, vitamins, and microneedling; minoxidil not tried due to concerns about dependence and side effects.

      community 3.5 months on Minoxidil, Weekly 0.6mm microneedle

       38 upvotes 5 months ago
      A trans woman experiencing male pattern baldness has been using Minoxidil and microneedling for 3.5 months, noticing visible hair regrowth. Despite initial skepticism, progress is evident, though a hair transplant might be needed for fuller coverage.

      community Temple regrowth, 5 months on fin + min

      in Progress Pictures  233 upvotes 6 months ago
      A trans man shared his 5-month progress using finasteride and minoxidil for temple regrowth, noting slow but steady results. Despite some negative comments, he received support and encouragement from others, with advice to start treatment early for best results.

      community 100 Day Progress & Managing Realistic Expectations (FTM 24)

       99 upvotes 8 months ago
      A trans man experiencing hair loss after starting testosterone treatment has seen positive results using topical minoxidil and finasteride, though his hair remains thin. He is considering continuing his current treatment and exploring additional options like microneedling and Breezula, while acknowledging the impact of testosterone on hair loss.

      community Oral minoxidil - how important is dermastamping?

      10 months ago
      A trans woman is using 10 mg oral minoxidil, dutasteride, and estradiol for hair regrowth and is also doing dermastamping despite the pain. Users discuss the benefits of dermastamping for serum absorption and hair follicle stimulation, with some expressing surprise at the high minoxidil dosage.

      community 2 months on topical minoxidil and derma rolling

      in Transgender  10 upvotes 9 months ago
      A 19-year-old trans female has been using topical minoxidil and dermarolling for nearly two months, alongside oral minoxidil, finasteride, spironolactone, and estrogen. She noticed significant hair improvement after starting topical minoxidil and dermarolling.

      community 5 months MTF HRT no min/fin/dut

       35 upvotes 2 years ago
      A 22-year-old trans woman has been on 6mg estradiol enanthate for five months. She reports thicker and healthier hair but not much regrowth yet.

      community 11 months progress, HRT + Fin + Min

      in Progress Pictures  366 upvotes 5 months ago
      A transwoman shared her 11-month progress using hormone replacement therapy (HRT), finasteride, and minoxidil, reporting significant hair regrowth and satisfaction with the results. The discussion included various perspectives on HRT, its effects on hair and sexual function, and personal experiences with similar treatments.

      community People who used cyproterone for hair loss

       2 upvotes 2 years ago
      The conversation discusses the use of 12.5mg cyproterone every other day for hair loss. There's a concern about reducing testosterone potentially increasing DHT and negatively affecting hair.

      community 14 Months Dut/Minox/Microneedling + 13 Months HRT

       38 upvotes 5 months ago
      The user shared their hair regrowth journey using treatments like dutasteride, minoxidil, microneedling, tretinoin, Nizoral, silica, biotin, and hormone replacement therapy (HRT) with cyproterone and estradiol. They reported substantial hairline improvement and some crown thinning, with hopes for further progress.

      community I don’t understand this, is he equating taking Fin with being on HRT?

       303 upvotes 1 year ago
      The conversation is about using finasteride and testosterone replacement therapy (TRT) for hair loss and their role in gender-affirming care. It debates whether these treatments are considered hormone replacement therapy (HRT) and their implications for both cisgender and transgender individuals.

      community Mixing spiro with liquid minox

       3 upvotes 2 years ago
      Mixing spironolactone with minoxidil for hair regrowth was discussed, with spironolactone being replaced by bicalutamide in a serum by Dr. Powers. Bicalutamide is not recommended for cis males due to potential side effects.