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GlossaryTopical JAK Inhibitors

medications applied to skin to block Janus kinase enzymes

Topical JAK Inhibitors, also known as Topical Janus Kinase Inhibitors or Topical JAKis, are medications applied directly to the skin to block the activity of Janus kinase enzymes. These enzymes play a role in the immune response and inflammation. By inhibiting them, these treatments can help manage conditions like alopecia areata, an autoimmune disorder that causes hair loss, by reducing inflammation and potentially promoting hair regrowth.

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community Topical Finasteride strength discussion

in Research/Science 65 upvotes 1 year ago

The conversation discusses the effectiveness of different concentrations and dosages of topical finasteride on scalp and serum DHT levels, comparing it to oral finasteride and noting the side effects seem to be fewer at lower dosages. Participants shared experiences and referenced a chart indicating similar scalp DHT reduction with 0.025% topical finasteride as with 1mg oral finasteride, but with fewer side effects.

community How insane is this oral min shed?

in Progress Pictures 111 upvotes 1 year ago

A user started taking 0.625mg oral minoxidil daily for hair loss, increased the dose to 1.25mg, and experienced a significant shed, losing 70% of scalp density. They cannot tolerate finasteride due to side effects but are hopeful for hair regrowth despite the shedding.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 85 upvotes 6 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community bye fellas, it’s time to quit this sub

in Progress Pictures 810 upvotes 9 months ago

A user successfully improved their hairline after 15 months using topical minoxidil and dutasteride. Some commenters question the necessity of treatment given the user's original hair condition, while others support early intervention.

community Why nobody uses 0.25% (2.5mg/ml)?

in Treatment 66 upvotes 1 year ago

The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

community Massive hair gains! Hope! May this post be a light to you in dark phases when all other lights go out

in Progress Pictures 193 upvotes 8 months ago

A 27-year-old man saw significant hair regrowth after starting a regimen in January that included topical minoxidil with finasteride, vitamins D and B12, fish oil, zinc with magnesium, quitting smoking, and intermittent fasting. People commented on the effectiveness of minoxidil in Southern populations and asked about the details and timeline of his treatment.

community Found a Pharmacy that will mix me 0.1 % Alfatradiol (Pantostin)

in Treatment 6 upvotes 5 months ago

The user is currently using 0.025% Pantostin but plans to switch to 0.1% Alfatradiol. They will also use high-dose Kx826, high-dose Minoxidil, and aggressive microneedling for hair regrowth.

community Almost 90 days. The hair gods taketh and now giveth.

in Progress Pictures 721 upvotes 1 year ago

User "mynameisbogus" shares hair regrowth progress after 90 days using Dutasteride, oral and topical Minoxidil, RU58841, dermarolling, and Keto shampoo. Others in the conversation praise the impressive results and discuss their own experiences with hair loss treatments.

community Finasteride only: Before vs 11 months

in Progress Pictures 437 upvotes 6 months ago

A user shared progress pictures showing hair improvement after 11 months of using finasteride. The user experienced minimal shedding and plans to continue the treatment long-term.

community What happened to topical dutasteride??

in Finasteride/Dutasteride 28 upvotes 6 days ago

Topical dutasteride is considered for hair loss, but concerns about systemic absorption and side effects like reduced libido are common. Users have mixed results, with some preferring oral finasteride or dutasteride despite side effects, while others find topical treatments beneficial but challenging.

community Topical fin/min + microneedling 3 month results

in Progress Pictures 34 upvotes 1 week ago

The conversation discusses hair loss treatments, specifically using topical finasteride and minoxidil combined with microneedling, along with supplements like collagen, vitamin C/D, and saw palmetto. The user also mentions using a DHT-blocking shampoo and experimenting with cold showers and contrast therapy for hair health.

community How come topical fin doesn't deliver superior results when it suppresses scalp DHT more effectively than oral?

in Finasteride/Dutasteride 36 upvotes 2 weeks ago

Topical finasteride is believed to reduce scalp DHT more than oral forms, but its effectiveness is questioned due to inconsistent application and absorption. Oral finasteride is considered more effective because it consistently reduces systemic DHT, ensuring more reliable results.

community Is there any role for topical DHT antagonists, or does a 5-AR inhibitor remove the need for them as therapy

in Research/Science 2 upvotes 3 weeks ago

Topical androgen receptor antagonists may not be necessary if 5-AR inhibitors like finasteride or dutasteride effectively reduce DHT levels. Combining a 5-AR inhibitor with a topical androgen antagonist could potentially enhance treatment, but oral use of androgen antagonists is too risky due to severe side effects.

community topical Minoxidil - Ru58841 makes my hair look and feel really brittle and thin

in Minoxidil 1 upvotes 1 month ago

Topical Minoxidil and RU58841 can make hair look brittle and thin, possibly due to the propylene glycol in their solutions. Some users experience side effects like heart palpitations with RU58841, while others have no issues.

community Haircafe - TOPICAL minoxidil is an anti aging drug

in Minoxidil 243 upvotes 1 month ago

Topical minoxidil may cause skin aging effects like wrinkles and dark circles, possibly due to its alcohol content, while oral finasteride is reported to make users look younger. Switching to oral minoxidil or using moisturizers might help reduce these skin issues.

community Topical aldactone for men’s hair and muscle effects

in Treatments 18 upvotes 1 month ago

Topical aldactone is discussed for its effects on men's hair and muscles. The conversation explores its potential benefits and side effects compared to other treatments like Minoxidil, finasteride, and RU58841.

community Topical FIN/MIN 0.03% / 6% (Day 2) HAIR IS CURRENTLY WET & PARTED. As you can see my main issues are the crown / mid scalp area. Can’t wait until I start seeing results!

in Finasteride/Dutasteride 10 upvotes 1 month ago

The conversation discusses using topical finasteride and minoxidil for hair loss, focusing on the crown and mid-scalp areas. The user is optimistic about seeing results in 3 to 6 months.

community Topical fin formulation question

in Finasteride 91 upvotes 1 month ago

A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

community Topical finasteride carrier/vehicle

in Finasteride 135 upvotes 2 months ago

The user is considering making a homemade topical finasteride solution using an ethanol-based carrier. They are inquiring if a solution containing partially denatured ethyl alcohol and benzalkonium chloride is suitable.

community Why not use hair system instead of Topical Hassle

in Hair Systems 18 upvotes 2 months ago

Topical treatments like minoxidil and finasteride are preferred for hair loss due to ease of use and natural appearance. Hair systems are considered high-maintenance and less genuine.

community 4 months topical minoxidil + 2 months finasteride

in Minoxidil 132 upvotes 2 months ago

Topical minoxidil and oral finasteride are effectively promoting hair growth with minimal side effects, such as no impact on sex drive. Users report positive results and reduced hair shedding, with some using a combination of topical foam containing both minoxidil and finasteride.

community Why isnt topical fin talked about more?

in Chat 44 upvotes 2 months ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community Topical Minoxidil Hyperresponder

in Minoxidil 9 upvotes 3 months ago

Minoxidil helped regrow hair from NW3 to NW2 in 5 months despite initial shedding, with additional use of Vitamin D3/K2 on the scalp. Users discuss patience during shedding and the importance of continuing treatments like Minoxidil and Finasteride.

community Topical dutasteride valid success stories

in Finasteride/Dutasteride 1 upvotes 3 months ago

Topical dutasteride may not significantly reduce hair loss and could potentially increase testosterone, leading to further hair loss. Users report side effects like mood changes, sleep issues, and severe side effects, with no significant progress in hair regrowth.

community Topical Anti-Androgen users. What are y’all using currently? And what do you believe has the best chance of being approved? Or best results?

in Technology 13 upvotes 3 months ago

RU58841 is considered effective by some users, but finasteride and minoxidil are commonly used with varying dosages to manage side effects. Users report different experiences with treatments like pyrilutamide, fluridil, and RU58841, with some seeing results and others not.

community Topical Exosomes w derma roller??

in Research/Science 1 upvotes 4 months ago

The conversation discusses using topical exosomes with a derma roller for hair loss. Users also mention minoxidil for treatment.

community Topical min/fin for 8 months. Still seeing continuous miniaturisation

in General 50 upvotes 4 months ago

After 8 months of using topical finasteride, hair miniaturization continues, raising concerns about its effectiveness. Microneedling is suggested as a possible complementary treatment.

community Why a lot of people seems to hate on topical fin even though it suppresses more scalp dht?

in Chat 20 upvotes 4 months ago

Topical finasteride may reduce more scalp DHT but is seen as inconsistent and messy compared to oral finasteride. Users report mixed results with both forms, with some preferring oral for its convenience and consistent dosing, while others find topical effective but harder to apply.

community Topical min users, how long does your evening routine take?

in Chat 8 upvotes 4 months ago

Applying Minoxidil takes users between 10 seconds to 20 minutes, with most finding quicker methods more efficient. Techniques vary from using foam, liquid, or spray, with some users recommending buzz cuts for easier application.

community Topical Dutasteride & Microneedling Works

in Finasteride/Dutasteride 6 upvotes 4 months ago

Topical dutasteride, especially at higher concentrations, can be effective for hair loss when combined with microneedling to enhance absorption. Users discuss the side effects of finasteride and dutasteride, with some preferring topical treatments to avoid systemic side effects.