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GlossarySystemic Lupus Erythematosus

autoimmune disease causing widespread inflammation and tissue damage

Systemic Lupus Erythematosus (SLE) is an autoimmune disease where the body's immune system mistakenly attacks its own tissues, causing widespread inflammation and damage to various organs, including the skin, joints, kidneys, and brain. Symptoms can vary widely but often include fatigue, joint pain, skin rashes, and fever.

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community Hair Remedies that Don't Work for Anybody Seeking Hair Regrowth

in Treatment 6 upvotes 4 years ago

Hair loss treatments discussed include minoxidil, finasteride, and RU58841. Salon products and supplements generally don't work for hair regrowth unless there's a severe nutritional deficiency, while hormonal treatments like estrogen and spironolactone can be effective.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 244 upvotes 2 months ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Minoxidil Finasteride heart problems

in Update 97 upvotes 7 months ago

A user experienced heart problems after taking 1mg finasteride and 2.5mg oral minoxidil and is considering quitting minoxidil. Others discussed their experiences with heart issues and minoxidil, with some suggesting topical minoxidil as a safer alternative.

community Seeking Advice: Unusual Hair Loss at 31 Years Old - Any Insights? (M)

in Chat 15 upvotes 8 months ago

A 31-year-old man who previously had good results with minoxidil, finasteride, and nizoral for hair loss is now experiencing unusual hair loss and side effects from finasteride. Respondents suggest it might be severe retrograde alopecia and recommend exploring other treatment options due to his inability to tolerate finasteride.

community A Systemic Review on Topical Marketed Formulations, Natural Products, and Oral Supplements to Prevent Androgenic Alopecia: A Review

in Research/Science 6 upvotes 6 months ago

Topical formulations, natural products, and CAM therapies are being used to treat Androgenic alopecia to avoid side effects of Finasteride and Minoxidil. The review covers various low-risk, alternative treatment options.

community My Ultimate Hair Regrowth Regimen: Minimizing Systemic Exposure While Maximizing Results

in Research/Science 16 upvotes 3 months ago

The regimen includes using a diluted 5.5% Minoxidil / 0.025% Finasteride solution daily, microneedling weekly, and ketoconazole shampoo twice a week to minimize systemic exposure while maximizing scalp DHT reduction. The goal is to achieve hair regrowth with minimal side effects.

community If apply topical fin goes systemic then does it matter where I apply it on the scalp?

in Finasteride/Dutasteride 10 upvotes 7 months ago

The conversation is about whether topical finasteride and minoxidil need to be applied directly to the affected areas of the scalp or if they can be spread through blood vessels. It also asks how long topical finasteride remains on a pillow.

community Ru with gloves because of Systemic absorption?

in Research/Science 10 upvotes 1 year ago

The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemic absorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.

community New systematic review on topical and systemic spironolactone (2023)

in Research/Science 7 upvotes 1 year ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. Topical and oral spironolactone show potential in improving hair growth when combined with topical Minoxidil.

community Evidenced Based Meta-Analyses and Systemic Reviews of Androgenic Alopecia and Treatments

in Research/Science 14 upvotes 4 years ago

Evidence-based treatments for androgenic alopecia, such as minoxidil, finasteride, low-level laser light therapy, dutasteride, platelet-rich plasma, and topical ketoconazole. It discusses the efficacy, safety, and mechanism of action of these treatments, as well as future developments in understanding this polygenic condition.

community Upcoming Setipiprant clinical trials hint at systemic daily dosage

21 upvotes 8 years ago

The conversation discusses the safety, tolerability, and efficacy of oral Setipiprant tablets for treating androgenetic alopecia compared to finasteride. It mentions the high cost of Setipiprant on the black market and the trial's end date in September 2017.

community I don’t believe that Pyri doesn’t go systemic.

in Research/Science 8 upvotes 1 year ago

User experienced hair thickening with pyri but also side effects like reduced sex drive. Stopping pyri and returning to CB restored sex drive, suggesting pyri may go systemic or be incorrectly formulated.

community Is it possible to create an estrogen mesotherapy/topical that doesn't go systemic?

in Research/Science 6 upvotes 1 month ago

The conversation discusses the potential of using topical estrogen treatments for hair loss without systemic absorption, highlighting challenges and possible solutions like using estriol. It also mentions other treatments like topical finasteride, microneedling, and scalp massage, while noting the limitations and side effects of current options.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community If half life of fin is 6-8 hours in the blood but 5-6 days in tissue (scalp) why don't people apply topical every 3-4 days to minimize systemic?

in Treatment 28 upvotes 1 year ago

The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.

community Most Recent Interesting Hairloss Studies: 10% Minox vs 5% Minox / Radio Rrequency Treatment for AA / Topical Ketoconazole / PRP+Minox vs Minox vs PRP / Alopecia as a systemic disease

in Treatment 88 upvotes 4 years ago

Treatments for hair loss, such as topical minoxidil, platelet-rich plasma therapy with or without minoxidil, ketoconazole, non-abative radio frequency, natural products, finasteride and cortexolone 17 alpha propionate. The post evaluates the efficacy and safety of these treatments in various studies.

community Dr. Kyle Gillet on Dr. Andrew Huberman's podcast said dutasteride mesotherapy blocks DHT conversion only in the scalp and called it the most promising topical currently. What's the scoop?

in Treatment 25 upvotes 2 years ago

Dr. Kyle Gillet mentioned on Dr. Andrew Huberman's podcast that dutasteride mesotherapy blocks DHT conversion only in the scalp and is the most promising topical treatment. Users discussed concerns about systemic absorption and the practicality of dutasteride injections.

community Any Topilutamide/Fluridil/Eucapil and/or topical Dutasteride experiences?

in Finasteride/Dutasteride 4 upvotes 6 months ago

The conversation discusses the effectiveness and systemic absorption of Topilutamide/Fluridil/Eucapil and topical Dutasteride for hair loss. Users are sharing their experiences and seeking success stories with these treatments.

community Topical finasteride in liposomal formulation

in Finasteride 5 upvotes 4 years ago

Topical finasteride in a liposomal formulation reduces systemic absorption compared to ethanol solutions. The user is seeking sources for such products, noting that popular options like morr-f are not liposomal.

community Topical minoxidil and Body hair

in Minoxidil 6 upvotes 1 year ago

Topical minoxidil can cause increased body hair due to systemic absorption, varying by individual skin sensitivity. The user seeks experiences and solutions to prevent this side effect.

community Estradiol mesotherapy / idea feedback

in Female 6 upvotes 3 weeks ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

community Theory As To Why Oral Minoxidil Might Be Helpful To People Compared To Topical Minoxidil

in Minoxidil 8 upvotes 2 months ago

Oral minoxidil may be more effective than topical due to uniform distribution and systemic activation, but can cause side effects like puffiness. Adding tretinoin to topical minoxidil can enhance its effectiveness by aiding conversion to its active form.

community Topical finasteride now the safest possible path?

in Finasteride/Dutasteride 82 upvotes 5 months ago

Topical finasteride is considered a safer option for hair regrowth with fewer systemic side effects compared to oral finasteride. Some users report similar efficacy and side effects between topical and oral treatments, while others prefer topical due to reduced systemic exposure.

community Solvent for topical fin with low absorption

in Product 2 upvotes 5 months ago

The conversation is about using distilled water as a solvent for topical finasteride to reduce systemic absorption. The user is considering avoiding ethanol and propylene glycol to achieve this.

community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 147 upvotes 7 months ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

in Finasteride/Dutasteride 36 upvotes 1 year ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

community Does Topical Finasteride Directly Reducing Scalp DHT?

in Finasteride/Dutasteride 15 upvotes 1 year ago

Topical finasteride reduces scalp DHT, with some going systemic. Using 0.025% at 1ml per day can stabilize hair loss without side effects.

community Oral minoxidyl and topical minoxidyl

in Minoxidil 2 upvotes 2 months ago

Using both oral and topical minoxidil is likely safe, but be cautious of increased systemic absorption. The best tretinoin dosage to enhance minoxidil effectiveness is not specified.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 5 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.