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GlossarySystemic Side Effects

unintended effects of a treatment affecting the entire body

Systemic Side Effects, also known as Systemic Adverse Effects or Systemic Reactions, refer to unintended effects of a medication or treatment that affect the entire body rather than just a specific area. For example, a drug prescribed for hair loss might cause nausea, dizziness, or changes in blood pressure, impacting multiple organ systems rather than just the scalp.

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Tracking 5 products like 7 Essengen-F, 100 RU58841 Powder, 13 Lonitab 10 mg, 252 Hair Solution Pyrilutamide Powder and 253 Hair Solution Pyrilutamide Powder 1g from by companies like MinoxidilMax, AllDayChemist and MV supplements . View all 5 products »

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community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 143 upvotes 5 months ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

community A Technical Question About Pyrilutamide

in Research/Science 5 upvotes 1 year ago

Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 119 upvotes 3 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Has Anyone Heard About Ethossomal Finasteride? 6x Finasteride Delivery in Hair Folicule?

in Finasteride/Dutasteride 36 upvotes 1 year ago

A user is considering switching from oral to topical finasteride to reduce systemic DHT impact and is exploring ethossomal finasteride for better skin penetration and potential hair regrowth. They found ethossomal finasteride in Brazil and are seeking opinions on its effectiveness compared to other topical delivery methods.

community oral minoxidil collagen contradiction

in Minoxidil 13 upvotes 4 months ago

The conversation discusses concerns about oral minoxidil potentially aging the face by affecting collagen, questioning its systemic effects. The user has successfully used topical minoxidil for years and is hesitant to switch to oral minoxidil.

community Is there any new drug that looks promising ?

in Research/Science 25 upvotes 7 months ago

The conversation discusses GT20029, a drug in Phase II trials that targets androgen receptors with minimal systemic effects, and TDM-105795, a growth stimulant with a different mechanism than minoxidil that may revive papilla stem cells. Both are potential new treatments for hair loss.

community A Nuanced Look at Microdosing Topical Finasteride

in Finasteride/Dutasteride 86 upvotes 11 months ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community GT20029 - Promising phase II results

in Research/Science 16 upvotes 6 months ago

GT20029 showed significant hair growth and safety in phase II trials, with no adverse sexual events. Users are hopeful but concerned about future costs and systemic effects.

community What makes breezula different than formula 82f?

in Question 8 upvotes 4 years ago

Breezula (clascoterone) and Formula 82F (topical finasteride) are treatments for hair loss that block DHT differently; Breezula competes with DHT at the hormone receptor site without systemic effects, while 82F inhibits the enzyme that converts testosterone to DHT. Breezula may work for those who don't respond to finasteride and vice versa.

community Minoxidil, low dose Finasteride, Pyrilutamide, Derma Rolling, shampoo... Why?

in Research/Science 11 upvotes 1 year ago

The conversation is about a person's hair loss treatment regimen, which includes Minoxidil, low-dose Finasteride, Pyrilutamide, weekly use of a derma roller, and hair loss shampoo. They chose these treatments to minimize systemic effects and plan to share their results for others' benefit.

community Stopping Minoxidil 12 Months in due to sudden side effects. Starting Nanoxidil, anyone have any success/horror stories?

6 upvotes 9 years ago

User experienced side effects from Minoxidil and is switching to Nanoxidil. They are also using Finasteride and seeking advice on preventing hair loss.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 9 upvotes 4 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community According to one study, topical spironolactone is more effective than topical finasteride for both men women.

in Treatment 12 upvotes 3 years ago

Topical spironolactone is more effective than topical finasteride for treating hair loss in both men and women. Oral spironolactone can affect testosterone, but the topical form doesn't impact the endocrine system.

community Has anyone ever used grape seed extract? Any negative effects on hair ?

in Treatment 6 upvotes 3 years ago

The conversation is about the effects of grape seed extract on hair, with mixed experiences reported. One user advises against using it.

community Dr Huberman - Cafeine when rubbed on the scalp can be as effective at times as minoxidil because it triggers 1GF-1

in Update 269 upvotes 1 year ago

Whether topical caffeine can be as effective for hair growth as minoxidil and finasteride, with various replies discussing the efficacy of these treatments and criticism of Dr. Huberman's research methods.

community [19M] Before and after pics 8 months after consistent use of Finasteride 1 mg and Minoxidil 5% 1ml every night, ketokonazole2%+salicylic acid mild shampoo everyday. I've used minoxidil only for the frontal, most significant area of the scalp for regrowth as 1 ml is not enough for entire scalp

in Progress Pictures 223 upvotes 2 years ago

User shared before and after photos of 8 months using Finasteride 1mg and Minoxidil 5% 1ml nightly, with positive results and no side effects. Others praised the progress and suggested alternative treatments like topical fin, CB-03-01, or RU58841.

community Is microneedling + minoxidil better than oral minoxidil

in Chat 26 upvotes 3 days ago

Oral minoxidil is considered more effective for hair regrowth than topical minoxidil, but it carries higher risks. Combining microneedling with topical minoxidil can enhance absorption, but oral minoxidil with microneedling shows significant results.

community So what’s really the deal with dutasteride hairline ruining claims?

in Finasteride/Dutasteride 72 upvotes 2 years ago

The potential effects of dutasteride on hair loss, with some users reporting it improved their hairline while others experienced worsened hair loss or shedding. Other treatments discussed include minoxidil and finasteride, as well as RU58841.

community Opinions & Experiences with topical Spironolactone?

in Treatment 7 upvotes 2 years ago

Hair loss discussion includes topical Spironolactone's effectiveness and minimal side effects. Community members share personal experiences and opinions on its use.

community Topical Dutasteride. Does it work?

in Finasteride/Dutasteride 13 upvotes 4 months ago

Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

community Post Finasteride Syndrome, A dangerous lie.

in Chat 142 upvotes 8 months ago

A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.

community Another update. Almost a year on Dutasteride and Oral Minoxidil, after several years on finasteride and topical minoxidil. I’m fairly certain my hair is objectively worse than it was 5 months ago.

in Update 59 upvotes 1 year ago

A user's experience with hair loss treatments, including Dutasteride, Oral Minoxidil and Finasteride; potential side effects; and the potential of using anti-androgens or microneedling.

community An argument for why we should take topical Dutasteride seriously

in Research/Science 85 upvotes 3 years ago

Topical Dutasteride may halt hair loss and effectively treat androgenic alopecia. Combining low-dose oral Dutasteride with topical application could maximize regrowth and minimize side effects.

community Reaction to High Dose Minoxidil After Year of Use

in Minoxidil 9 upvotes 5 years ago

A male with early-stage hair loss experienced severe side effects, including sexual dysfunction from finasteride and increased heart rate and fatigue from high-dose minoxidil, leading to discontinuation of both treatments. He is now relying on DHT-blocking shampoos and awaiting new treatments.

community pyrilutamide log from someone who couldnt take fin/min/ru due to sideeffects

in Progress Pictures 99 upvotes 2 years ago

A user (seblt) who has had side effects from finasteride, minoxidil and RU58841 but is now trying pyrilutamide as a last resort, with other users providing advice and support. They have already seen some baby hairs growing after 10-14 days of treatment and will provide updates in 1-2 weeks.

community Anyone switch topical minoxidil to oral and stay on it for over a year?

in Minoxidil 11 upvotes 11 months ago

Someone switched from topical minoxidil to oral minoxidil and found it more effective and convenient, reporting improvements in hair, eyebrows, eyelashes, and beard without scalp issues. They are seeking long-term experiences from others who made the same switch.

community Hims Fin/Min spray - 2 months in - already using Min/keto for 15y

in Finasteride/Dutasteride 18 upvotes 1 year ago

The user has been using Minoxidil for 15 years and recently started using a topical Finasteride spray, noticing an increase in small, thickening hairs after two months. They experienced side effects with oral Finasteride but only minor ones with the spray, and still have more than half the bottle left after two months of use.

community Study Shows That Oral Minoxidil Is Not Only Good At Improving Hair But Also Reducing Arterial Stiffness And Preventing Other Health Problems

in Minoxidil 22 upvotes 3 years ago

Oral minoxidil may improve hair growth, reduce arterial stiffness, and prevent other health issues. Some users believe it is an effective treatment despite concerns about its effects on skin and blood.

community CASSIOPEA ANNOUNCES VERY POSITIVE PHASE II TWELVE MONTHS RESULTS FOR BREEZULA® (CLASCOTERONE) IN TREATING ANDROGENETIC ALOPECIA

in Update 162 upvotes 5 years ago

Clascoterone (Breezula) showed positive results for treating hair loss without affecting cortisol levels. Opinions vary, with some users optimistic about its potential and others critical of its effectiveness compared to existing treatments like finasteride.

community Can RU58841 stop hairloss for a long time?

in Research/Science 11 upvotes 10 months ago

A user is considering using RU58841 to treat hair loss and asks if it can be effective for 4-5 years. Some suggest starting with a lower concentration and debate the safety of RU58841 compared to approved drugs like finasteride.