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GlossaryStratum Spinosum

layer of the epidermis with spiny-shaped keratinocytes

The Stratum Spinosum, also known as the spinous layer or prickle cell layer, is a layer of the epidermis located just above the Stratum Basale. It consists of several layers of keratinocytes that are connected by desmosomes, which give the cells a spiny appearance under a microscope. This layer plays a crucial role in providing strength and flexibility to the skin.

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community microneedle, any long term users damage?

in Microneedling 35 upvotes 5 months ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Why do I see so many people here recommend microneedling?

in Microneedling 108 upvotes 1 year ago

The efficacy of microneedling for hair regrowth as either a stand-alone therapy or adjunct to Minoxidil, and whether Tretinoin is a safer and more effective option. Replies include personal accounts from users who have had success with microneedling in combination with minoxidil and peptide serums, as well as considerations of technique, depth, and potential scarring.

community Dr Kyle Gillett on topical Dutasteride

in Finasteride/Dutasteride 56 upvotes 1 year ago

The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

community Trying to regrow crown been on Fin for 4.5 years

in Finasteride/Dutasteride 6 upvotes 6 months ago

The user has been on finasteride for 4.5 years and minoxidil for 10 years, maintaining hair but not regrowing much on the crown and temples. They are considering using a dermastamp more frequently and possibly trying RU58841, but are hesitant about dutasteride due to concerns about side effects and DHT suppression.

community Tretinoin can make it worse!!!

in Chat 7 upvotes 1 year ago

Tretinoin may enhance minoxidil's effectiveness for those not responding to minoxidil alone, but it could reduce efficacy for some who are already responding to minoxidil. Tretinoin requires careful use, including skin moisturizing and sun protection due to increased sensitivity.

community Has anybody tried retinol (not Retin A aka tretinoin) combined with minoxidil?

in Treatment 21 upvotes 2 years ago

The conversation is about someone who had success using retinol with minoxidil for hair growth, but experienced shedding with Retin A (tretinoin). They are asking if others have tried retinol with minoxidil and what their results were.

community Topical tretinoin increases minoxidil absorption by 3x. Thoughts?

in Minoxidil 39 upvotes 5 years ago

Topical tretinoin can increase the absorption of minoxidil by three times, which may enhance its effectiveness for hair loss treatment. Tretinoin causes increased skin turnover, making the skin more permeable and potentially improving minoxidil's efficacy.

community Finasteride can revive up to 7 year old dead hair

in Research/Science 188 upvotes 1 month ago

Finasteride and minoxidil can revive hair dormant for up to 7 years, with microneedling enhancing regrowth. Users report significant hair regrowth even after long periods of baldness.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 71 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Topical Dutasteride. Does it work?

in Finasteride/Dutasteride 13 upvotes 5 months ago

Topical dutasteride may be effective for hair loss by staying in the scalp and minimizing bloodstream absorption, potentially improving hair results and reducing side effects. The user seeks advice on its effectiveness.

community Comprehensive Microneedling Guide

in Microneedling 295 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community Homemade Topical Finasteride Formula?

in Treatment 7 upvotes 2 years ago

User wants to make homemade topical finasteride to minimize side effects and asks about using glycerin, stirring time, storage, and alternative solvents. Another user's comment is unclear.

community DIY treatment... Shedding completely stopped after 1.5 yrs

in Treatment 246 upvotes 2 years ago

Vitamin C mixed with shampoo stopped shedding and promoted hair regrowth after 1.5 years. Both the person and their wife experienced significant hair loss reduction with this method.

community A Different Take on Curing MBP

16 upvotes 5 years ago

Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

community Norwood Reaper got the Iron Man himself

in Shaved/buzzed 34 upvotes 2 years ago

The conversation is about Robert Downey Jr. shaving his head, likely for a movie role, and comments on his appearance and strong genes. No specific hair loss treatments like Minoxidil, finasteride, or RU58841 are mentioned.