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GlossarySkin Microenvironment

complex and dynamic environment within the skin influencing health

The skin microenvironment refers to the complex and dynamic environment within the skin, including various cell types, extracellular matrix components, and signaling molecules. It plays a crucial role in maintaining skin health, influencing processes like wound healing, immune responses, and hair growth. Understanding the skin microenvironment is essential for developing treatments for conditions like alopecia and other skin disorders.

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Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

in Research 413 upvotes 2 weeks ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community My progress story for my hair loss treatment

in Progress Pictures 404 upvotes 1 year ago

User's hair loss treatment progress includes 1 mg finasteride, 2.5 mg minoxidil tablets twice daily, microneedling 3 times a week, and Fungoral shampoo twice weekly. Good progress and minimal side effects reported.

community Verteporfin with Microneedling (3mm-3.5mm): Bald to Full Head of Hair? Theory

in Technology 208 upvotes 11 months ago

The conversation is about using Verteporfin with microneedling as a potential hair loss treatment that may regenerate hair follicles with minimal scarring. There are concerns about the optimal dosage and the DHT sensitivity of the new follicles.

community Is it just me, or when people start having MPB symptoms, every single person you look at you start analyzing their hair? Ik it sounds weird

in Chat 168 upvotes 5 months ago

A user discusses their habit of analyzing others' hair due to their own hair thinning at 18. Another user mentions starting finasteride in 2010 and still having a full head of hair.

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 47 upvotes 7 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

in Research/Science 1 upvotes 2 weeks ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Some more realistic 15 months fin+min results. No loss, but also basically no growth. HT unfortunately seems like the only option left at this point :/

in Progress Pictures 116 upvotes 6 months ago

User shared 15-month results using finasteride and minoxidil, showing no loss but minimal growth, considering a hair transplant. Replies suggest starting treatment earlier, continuing current treatment, or getting a transplant.

community Please stop looking for a natural way to stop your hairloss

in Chat 247 upvotes 2 years ago

There is no natural way to stop hair loss; pharmaceuticals like minoxidil, finasteride, and RU58841 are the only effective treatments. Some users report success with minoxidil and microneedling, while others discuss the side effects of finasteride.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community 3 months progress on fin and min + micro needling (19m)

in Progress Pictures 762 upvotes 1 year ago

A 19-year-old male shared his 3-month hair regrowth progress using finasteride, minoxidil, and microneedling, with noticeable improvement. He uses 1mg oral finasteride daily, 5% minoxidil foam twice a day after day 80, and microneedles with a 1.5mm derma stamp every 1-2 weeks.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 6 months ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community Theoretically won't this be better than finasteride? Azelaic acid + zinc

in Research/Science 8 upvotes 1 year ago

The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

community 4 Year Update (27M)(Fin+Min+Micro-needling)

in Progress Pictures 1774 upvotes 1 year ago

EDHARRINGTON's journey to regrow his hair using finasteride, topical minoxidil, and micro-needling treatments over 4 years, with others commenting their support and admiration for his results.

community Shrooms have done more for my hair loss than all of my hair supplements/medications combined.

in Satire 408 upvotes 1 year ago

Finding acceptance of hair loss through psychedelics, and the potential benefits of shrooms. Discussions include sharing experiences with minoxidil, finasteride, nutrafol, laser therapy, micro needling, as well as mental health concerns such as depression, suicidal thoughts, and self-esteem.

community Lion Mane Part 2: Microneedling with Topicals, beneficial compounds, maybe?

in Microneedling 1 upvotes 7 months ago

The conversation discusses microneedling techniques and the use of Minoxidil, copper peptides, EGF, FGF, ceramides, and hydration serums to enhance hair growth. It explores optimizing scalp conditions and the potential benefits of various compounds in conjunction with microneedling.

community Second update: almost 3.5 months min microneedling 1.5mm once a week ketoconazole shampoo 4 times a week

in Update 586 upvotes 2 years ago

A user's hair loss treatment regimen, which includes minoxidil, ketoconazole shampoo and microneedling; some participants questioned the results due to previous posts about hair transplants, but others agreed that quick results are possible with certain treatments.

community Comprehensive Microneedling Guide

in Microneedling 290 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

community I don't know what happened with me sudden hair loss from 6 months i use dut ,min , vitamin all things but no response

in Progress Pictures 18 upvotes 1 year ago

The person is experiencing sudden hair loss for six months and treatments like dutasteride, minoxidil, and vitamins are not working. Another person suggests the hair loss might not be androgenetic alopecia but could be telogen effluvium or an inflammatory condition.

community Dude had better hair at over 100 years of age than many of us at 20

in Satire 1454 upvotes 1 year ago

Hair loss discussion mentions Native Americans' resistance to male pattern baldness and lack of facial hair. Users discuss genetics, sun exposure, and potential treatments like minoxidil and finasteride.

community “You can’t regrow hair that’s gone.” HMB

in Progress Pictures 32 upvotes 1 year ago

User regrew lost hair using microneedling, minoxidil, finasteride, Nizoral, fish oil, and collagen peptide. Progress was slow but constant, and patience was important.

community (Updated) 9month hair gains on fin,min,niz

in Progress Pictures 711 upvotes 2 years ago

A user's nine-month journey of hair growth with treatments including finasteride, minoxidil, and nizoral; some participants thought the user had a hair transplant while others disagreed.

community 2.5 months minoxidil 5% twice daily ,dermarolling 1.5mm 1 in week ,ketoconazole 2% shampoo. above is before down is after

in Progress Pictures 497 upvotes 2 years ago

A user's progress with using Minoxidil 5% twice daily, dermarolling 1.5mm once per week and ketoconazole 2% shampoo for 2.5 months. Other users have suggested that the user should also use finasteride in order to maintain their results.

community My Testosterone results before and after Finasteride

in Update 146 upvotes 3 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community 12 mo 1 ml daily Min/Dermaroller 1mm-1.5mm update + AGA progression theory and specific order of treatment

in Microneedling 15 upvotes 3 years ago

A user shared their year-long hair loss treatment using minoxidil, microneedling, and scalp massages, reporting moderate hair growth and stabilization. They suggest starting early with less harmful methods and consider adding finasteride or dutasteride if needed.

community progress has been insane, been having a bad shed for about a month or 2, can anyone explain?

in Progress Pictures 678 upvotes 4 months ago

User experienced significant hair regrowth using minoxidil and dutasteride, along with microneedling, vitamins, and massages. Despite recent shedding, they hope it's a synchronized hair cycle and plan to continue the treatment.

community Impressed by the progress but think it’s time to go for the transplant?

in Progress Pictures 288 upvotes 10 months ago

The user started taking 2.5mg minoxidil tablets daily and reduced their finasteride dose to 0.5mg due to side effects. They are considering a hair transplant but are unsure if they should proceed now or wait after seeing the effects of the reduced finasteride dosage.

community Minoxidil alternative with a week long half-life? Why isn’t it possible?

in Satire 2 years ago

This conversation discussed the potential for a hair loss treatment alternative to minoxidil, with many users debating the economic and health implications of such an option. Some suggested that finasteride could be used as an alternative, while others argued that this would ultimately not benefit pharmaceutical companies due to their reliance on planned obsolescence.

community Finasteride can revive up to 7 year old dead hair

in Research/Science 188 upvotes 2 months ago

Finasteride and minoxidil can revive hair dormant for up to 7 years, with microneedling enhancing regrowth. Users report significant hair regrowth even after long periods of baldness.

community Minoxidil Beard Growth Stack + Protocol (Only 1.5 years commitment)

in Minoxidil 7 upvotes 7 months ago

A user shared a beard growth protocol involving hydration toner, azelaic acid, tretinoin, moisturizer, 5% topical minoxidil, and SPF 30+ sunscreen. The regimen spans a year to a year and a half, with specific application schedules for different phases.

community My result with 5month min+micro1m+tretinoin0.0025+nizoral

in Progress Pictures 100 upvotes 1 year ago

The conversation discusses hair loss treatment results after 5 months using Minoxidil, microneedling with a 1mm length every 5 days, Tretinoin (0.0025%), and Nizoral. The user noticed an increase in hair density.