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GlossarySebaceous Gland

small skin gland producing oily sebum for lubrication

A sebaceous gland, also known as an oil gland, is a small gland in the skin that produces sebum, an oily substance that helps to lubricate and protect the skin and hair. These glands are typically found in high concentrations on the face and scalp and are connected to hair follicles, releasing sebum through the hair follicle to the surface of the skin.

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community Dr Kyle Gillett on topical Dutasteride

in Finasteride/Dutasteride 56 upvotes 2 years ago

The potential effectiveness of topical dutasteride, as well as other hair loss treatments such as finasteride, RU58841, minoxidil, and various vitamins. Experiences from users who have used these treatments were shared.

community Solving Hair Loss with Research at MIT

in Research/Science 594 upvotes 2 months ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community A hill on which I will die: The DHT itch absolutely exists

in Research/Science 208 upvotes 7 months ago

The DHT itch is linked to hair loss and persists despite finasteride use; switching to dutasteride helped alleviate the itch and promoted regrowth. Some users suggest seborrheic dermatitis as a cause and recommend treatments like medicated shampoos, vitamin D, and minoxidil.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

community "DHT Itch" and onset Seborrheic Dermatitis

in Research/Science 76 upvotes 1 year ago

The post and conversation discuss the link between DHT (a hormone), scalp itchiness, and hair loss. Some users share their experiences and treatments, including the use of fluconazole, corticosteroids, and ketoconazole shampoo, with one user suspecting minoxidil as a potential cause of their symptoms.

community Could a reversed SARM designed for the scalp serve as a replacement for oral Dut and Fin?

in Finasteride/Dutasteride 2 upvotes 2 weeks ago

The conversation discusses the potential of developing a selective oral SARM to target androgen activity in the scalp and skin, as an alternative to oral Dutasteride and Finasteride, which have systemic side effects. It also mentions Clascoterone and RU58841 as topical treatments for hair loss.

community Serum DHT CAN'T cause hair loss. Sebum DHT is a better measurement.

in Research/Science 19 upvotes 2 months ago

Serum DHT is mostly inactive; sebum DHT is a better measure for hair loss. Users discuss using finasteride, dutasteride, and topical treatments like KX826 and RU58841 for better scalp DHT suppression.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 2 months ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community One of the best things about Finasteride and Dutasteride is no more itchy scalp

in Finasteride/Dutasteride 54 upvotes 5 months ago

Finasteride and Dutasteride help reduce itchy scalp and dandruff caused by DHT. Users also report less acne and reduced hair loss.

community Why does Finasteride make my hair not get greasy fast anymore?

in Finasteride/Dutasteride 31 upvotes 7 months ago

Finasteride, a hair loss treatment, was observed to reduce scalp oiliness in users. Anti-androgens like Finasteride are known to decrease the activity of oil-producing glands.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 134 upvotes 8 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Hair loss returned suddenly and rapidly after a year on only oral minoxidil? Hair getting greasy fast.

in Chat 10 upvotes 8 months ago

User experienced sudden, rapid hair loss after a year on 2.5mg oral minoxidil. They are hesitant to use finasteride due to anxiety and depression concerns.

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 1 year ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

community Finasteride gives me seb derm. Thoughts on zinc or other options?

in Chat 16 upvotes 2 years ago

A user with diffuse hair loss after taking accutane, which might have triggered genetic predisposition to AGA; their experience taking finasteride and experiencing side effects of increased oil production, increased sex drive, worsening hair texture; they are considering zinc supplementation with finasteride or other treatments such as alfatradiol or spironolactone.

community He used Dutasteride for 20 years. Interview

in Treatment 109 upvotes 1 month ago

Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

community Derm says my hair loss (diffuse) is from seborrheic dermatitis. Anyone else have experience with this? I was already prepared to jump on fin min

in Research/Science 25 upvotes 3 weeks ago

Seborrheic dermatitis can cause hair loss, and treatments like ketoconazole shampoo, topical steroids, and oral antifungals may help. Some consider using finasteride and minoxidil for hair loss despite dermatitis.

community DHT is about to get smashed ….

in Update 801 upvotes 3 months ago

The conversation discusses hair loss treatments like topical finasteride with minoxidil, oral dutasteride, and essential oils. Oral treatments like dutasteride and finasteride are seen as more effective, though some prefer topicals to avoid side effects.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community For those who switched from finasteride to Dutasteride !

in Chat 43 upvotes 10 months ago

People discussed switching from finasteride to dutasteride for hair loss treatment. They reported satisfaction with dutasteride, noting it was more effective than finasteride, particularly after finasteride's effects diminished, and some experienced additional benefits like cost savings and stabilized hair loss, rating dutasteride highly as a treatment.

community Anyone else crying themselves to sleep because of the pyrilutamide fail?

in Technology 41 upvotes 1 year ago

The conversation is about disappointment with pyrilutamide's performance as a hair loss treatment, with some users expressing interest in other treatments like Verteporfin, GT20029, and RU58841, while others suggest sticking with established treatments like finasteride or dutasteride.

community Dutasteride at 21 years old. Is it safe?

in Finasteride/Dutasteride 12 upvotes 1 year ago

A 21-year-old individual questioning the safety and potential side effects of using Dutasteride for hair loss, after Finasteride and RU58841 had limited effect. The responses vary, with some users suggesting it's safe and others advising to check hormone levels before proceeding.

community Is GT20029 supposed to regrow hair as well?

in Treatment 10 upvotes 1 year ago

The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community How much dht does Nizoral shampoo block?

in Ketoconazole 101 upvotes 3 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, and Nizoral shampoo. Nizoral's effectiveness is debated, with some suggesting it works as a weak antagonist for androgen receptors, while others attribute its benefits to anti-fungal and anti-inflammatory properties.

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

in Progress Pictures 83 upvotes 2 years ago

Treating Seborrheic Dermatitis, a fungal scalp condition which can cause hair loss. Treatments discussed include antifungal shampoos, cold showers, exfoliating the scalp, taking Vitamin D, and stimulating the prostate through the anus.

community The Ordinary hair serum / Redensyl / Taxifolin initial experiences

2 upvotes 5 years ago

A user shared their initial experiences with The Ordinary hair density serum, which contains Redensyl (taxifolin). They observed increased hair volume but also developed pimples, likely due to the serum stimulating sebaceous glands.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 3 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Can absorption be intervened by oil, sebum etc?

in Treatment 3 upvotes 3 months ago

The conversation discusses whether oily scalp and sebum can hinder the absorption of topical hair loss treatments like Minoxidil and Finasteride, even when using tretinoin. The user is skeptical about the effectiveness of these treatments due to their oily scalp condition.

community Best Treatment In The Pipeline?

in Chat 15 upvotes 5 months ago

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

community my own advise on what has worked for me

in Chat 15 upvotes 3 years ago

The user recommends washing hair twice daily with glycerin soap, using finasteride and minoxidil, avoiding cigarettes and alcohol, and maintaining a diet rich in fruits and vegetables. They claim these methods have significantly improved their hair health over 25 years.