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Glossary Placebo Effect

The placebo effect refers to the phenomenon where individuals experience a perceived improvement in their condition after receiving a treatment that has no therapeutic effect, often due to their expectations or beliefs about the treatment. In the context of hair loss, the placebo effect can significantly influence the outcomes of clinical trials for hair restoration therapies, as participants may report hair regrowth or reduced shedding simply because they believe the treatment is effective. Key distinguishing characteristics include the psychological component of belief and expectation, which can lead to real physiological changes, even in the absence of active ingredients.

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community Why hasn’t anybody or any company done experiments on whether minoxidil and finasteride have effects on human collagen and elastin after a year of use compared to placebo? (In vivo not vitro)

6 upvotes 7 months ago

The conversation discusses the lack of in vivo studies on the effects of minoxidil and finasteride on human collagen and elastin after a year of use. It highlights the potential benefits of such research for understanding side effects and improving sales, despite challenges like cost and competition.

community The Placebo Group Has It Worse Than The Standard Prescription 0.5mg Group. -The fear is all in your head.

190 upvotes 11 months ago

Dutasteride at 0.5mg may have fewer sexual side effects than expected, with many side effects attributed to psychological factors (nocebo effect). The placebo group experienced more side effects, suggesting fear and anxiety might contribute to perceived side effects.

community Caffeine really a DHT blocker or placebo?

in Research/Science 7 upvotes 2 years ago

Caffeine is not a proven DHT blocker and does not effectively treat hair loss. Minoxidil, finasteride, and RU58841 are more reliable treatments.

community Am I getting results or is this just a placebo?

in Progress Pictures 9 upvotes 1 year ago

The conversation is about a user sharing their 40-day progress using dutasteride, topical Minoxidil, keto shampoo, and dermapen for hair loss, seeking opinions on whether the results are real or a placebo effect. Most responses suggest it's too early to see significant results and recommend continuing the treatment for 6-12 months for noticeable changes.

community Dutasteride and TRT study indicates improvement in aging male symptoms and no difference between placebo group and dutasteride group

in Finasteride/Dutasteride 45 upvotes 1 month ago

Dutasteride is recommended for men on testosterone replacement therapy (TRT) with DHT-sensitive hair, as it does not interfere with TRT's anabolic effects and may improve libido and aging male symptoms. Users report varying experiences with libido when switching from finasteride to dutasteride, with some noticing improvements and others experiencing fluctuations.

community Korean Laser Helmet has a 44% increase in hair growth vs 0% growth in placebo in a double-blinded randomized controlled clinical trial.

3037 upvotes 11 months ago

A Korean laser helmet increases hair growth by 44% compared to a placebo. Users discuss its cost-effectiveness, clinical support, and compare it to treatments like finasteride and minoxidil, focusing on wavelength and energy density.

community Pumkin Seed Oil 400mg/day oral, 6 month Randomized, Double-Blind, Placebo-Controlled Trial (N=76)

4 upvotes 3 years ago

Pumpkin seed oil may increase hair count but not thickness, though its effectiveness is debated. Some suggest using topical finasteride or saw palmetto instead.

community Pyrilutamide phase III clinical trial results released

in Research/Science 31 upvotes 2 years ago

Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

community Here's why Pryiltamide "failed" phase 3 trials and marketed as a cosmetic

in Chat 8 upvotes 2 years ago

KX-826 failed Phase III trials due to high placebo effects, patient compliance issues, COVID-19 side effects, and detection method deviations. KX-826 is now marketed as a cosmetic and approved for combination with Minoxidil.

community Is there a consensus on RU these days? Pyril turned out to be a bust right?

in Research/Science 17 upvotes 2 years ago

The conversation discusses the effectiveness and safety of hair loss treatments, specifically RU58841 and Pyrilutimide (Pyril), with users sharing that Pyril was no more effective than a placebo and expressing concerns about the safety of RU58841 based on personal experiences and the lack of pharmaceutical interest.

community TDM-105795 phase 2 results are in!

27 upvotes 2 years ago

TDM-105795 showed promising hair growth results, with higher efficacy than placebo and minimal side effects. It activates dormant hair follicle stem cells and may maintain gains without immediate loss, unlike minoxidil.

community Has anyone seen the data on this 539% boost breakthrough?

866 upvotes 6 months ago

Topical Clascoterone showed a 539% improvement in hair count compared to placebo, but its effectiveness and safety are debated. Users compared it to minoxidil and finasteride, with mixed opinions on its potential release in 2026 or 2027.

community Solution for male pattern baldness

245 upvotes 9 months ago

A new hair loss treatment claims a 539% improvement over placebo, but skepticism remains due to lack of substantial evidence and reliance on percentage figures. Users discuss the effectiveness of existing treatments like Minoxidil and Finasteride, expressing doubt about the new solution's impact.

community Clascoterone ph3 results ready

10 upvotes 9 months ago

Clascoterone 5% solution showed a 539% improvement in hair count compared to placebo, but the actual increase in hair growth is minimal. Users express skepticism about the effectiveness of hair loss treatments.

community Clascoterone 12 months phase 3 result out

42 upvotes 5 months ago

Clascoterone is promising for hair loss, showing 24.5% improvement in satisfaction compared to placebo. Users consider it an alternative to finasteride, with concerns about absorption and side effects.

community I saw results in just 10 days ..

in Minoxidil 6 upvotes 5 months ago

The user reported noticeable hair thickening after 10 days of using oral minoxidil and finasteride, but others suggested it might be an April Fool's joke or a placebo effect. The user also mentioned a high protein intake and regular gym workouts, while others discussed concerns about finasteride's side effects.

community Shouldn’t it be impossible for dutasteride to make hair loss worse?

in Finasteride/Dutasteride 39 upvotes 2 years ago

Dutasteride is unlikely to worsen hair loss; shedding is often temporary. Other factors like inconsistent use, placebo effect, or additional treatments may influence perceived results.

community Is this vellus hair along my hairline a sign of natural regrowth at 21?

in Is this regrowth? 5 months ago

A 21-year-old noticed vellus hair regrowth on their hairline after adopting a healthy lifestyle and meditation, without using treatments like Minoxidil or Finasteride. Other users are skeptical, attributing the regrowth to placebo effects.

community Took a month break from oral minox, wondering the logistics

in Minoxidil 1 upvotes 5 months ago

A 20-year-old stopped oral minoxidil (3mg) for a month due to health concerns and lack of significant results, while continuing topical minoxidil (7%) with tretinoin and finasteride (1mg). They experienced placebo side effects and are considering resuming oral minoxidil, seeking advice on potential setbacks.

community Veradermics VDPHL01 Topline Results for Extended-Release Oral Minoxidil

75 upvotes 4 months ago

Extended-release oral minoxidil (VDPHL01) shows promising results for hair growth with improved safety, achieving significant hair count increases and minimal side effects compared to placebo. The treatment is designed to maintain effective concentrations while reducing side effects, making it a safer option for those who cannot tolerate standard minoxidil.

community Breezula 6 Month Topline Phase III Results Released

172 upvotes 9 months ago

Breezula shows promising hair growth results, with up to 539% increase in hair count compared to placebo, and regulatory submissions are planned in the US and EU. Users are cautiously optimistic, noting the potential for Breezula to replace finasteride by targeting DHT without systemic effects.

community Anyone know anything about either of these products?

2 months ago

The conversation discusses hair loss treatments, specifically finasteride, minoxidil, and onion-based products. Users joke about the smell and effectiveness, with some suggesting onion products might be a placebo or scam.

community Why us no one talking about this?

in Treatment 61 upvotes 9 months ago

A new hair loss treatment reportedly shows a 539% improvement in hair count, but skepticism remains due to unclear placebo results and potential minimal actual hair growth. Many users doubt its effectiveness and market viability, citing high costs and lack of visual proof.

community Advice needed - Is it safe to use this rosemary oil without diluting?

in Microneedling 5 months ago

The conversation discusses whether rosemary oil can be applied directly to the scalp without dilution, with some users suggesting it is already diluted and safe to use. However, many emphasize that treatments like Minoxidil and Finasteride are more effective for hair loss, while rosemary oil is seen as less effective or a placebo.

community Alright so FDA better approve PP405 as fast as they approved covid vaccine

129 upvotes 1 year ago

PP405 is a potential hair loss treatment showing promising early results, with hopes for market release by 2028, but skepticism remains due to inconclusive data and past disappointments with similar products. Current treatments like Minoxidil and Finasteride have side effects, leading some to anticipate PP405 as a safer alternative, though its effectiveness compared to placebo is debated.

community Exercise seems to be helping, a lot, quickly.

in Chat 1 upvotes 1 year ago

Exercise may be improving hair thickness and reducing thinning for a 50-year-old man using topical finasteride, minoxidil, Nizoral, and microneedling. The improvement could be due to exercise, the treatments, or a placebo effect.

community Creatine effects on DHT Experiment

57 upvotes 2 years ago

Creatine might increase hair loss due to increased DHT sensitivity, but evidence is mostly anecdotal. The user is using oral minoxidil for hair loss and is cautious about starting creatine.

community Is it effective to make microneedling without minoxidil?

in Chat 31 upvotes 10 months ago

Microneedling can be effective for hair growth, but it is more effective when combined with minoxidil. Finasteride or other DHT suppressants are necessary to prevent hair loss due to male pattern baldness.

community Effectiveness and Safety of Hair Growth Formulation Containing Tectona grandis L.f (Teak) Leaf Extract

in Chat 33 upvotes 1 year ago

Teak leaf extract shows potential as a mild hair growth promoter for androgenic alopecia, with similar positive trends to minoxidil but without significant side effects. It can be made at home using dried teak leaves and ethanol, though its effectiveness compared to other treatments like finasteride is debated.

community Reason why placebo group got regrow on trial phase 3

in Chat 16 upvotes 2 years ago

Placebo hair regrowth might be influenced by propylene glycol in lotions or participants lying about using other treatments like minoxidil, finasteride, or microneedling. Being part of a study can also improve hair health due to lifestyle changes.