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Glossary pH

measures acidity or alkalinity of a substance on a scale

pH is a measure of how acidic or basic a substance is, on a scale from 0 to 14. A pH of 7 is considered neutral, while values below 7 indicate acidity and values above 7 indicate alkalinity. In the context of hair and scalp health, maintaining a balanced pH (around 4.5 to 5.5) is crucial for preventing issues like dryness, irritation, and microbial growth.

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community Phase 3 for PP405 will now start in 2027

in Chat 81 upvotes 1 month ago

Phase 3 for PP405 will start in 2027, disappointing many who expected it this year. Some users are trying treatments like topical minoxidil and topical dutasteride while waiting for new developments.

community Phase 2B trial for PP405 leaked (The study Pelage DOESN'T want you to see)

5 months ago

The conversation discusses hair loss treatments, mentioning minoxidil, finasteride, RU58841, VDPHL, GT20029, and follicle cloning as potential solutions. It also reveals that the discussion about PP405 was an April Fool's joke.

community Phase II topical dut study - outperforms oral fin with a minor DHT reduction

in Research/Science 61 upvotes 7 months ago

Topical dutasteride 0.05% is more effective for hair growth than oral finasteride 1mg, with minimal DHT reduction. The formulation uses castor oil and MCTs for better absorption but is not widely available until 2028.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

2 upvotes 1 year ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Photo results of oral min have many got growth from it

in Progress Pictures 1 upvotes 1 year ago

The user is seeking before-and-after photos of hair growth results from using oral or topical Minoxidil, as they couldn't use Finasteride but are using RU58841. They are curious about the effectiveness of Minoxidil alone.

community Phase 3 of pyrilutamide (kx-836) analysis of the efficacy

in Research/Science 11 upvotes 2 years ago

The conversation discusses the less impressive results of Pyrilutamide (kx-836) in phase 3 compared to phase 2, with a suggestion that a longer study might show more significant results. One user reports personal success with Pyrilutamide, experiencing no further hair loss and gradual regrowth.

community PHG Invites

4 upvotes 10 years ago

The conversation discusses a community called PHG, which focuses on experimental hair loss treatments and scientific approaches to hair regrowth. It mentions treatments like Minoxidil, finasteride, and RU58841, and highlights interest in new treatments like Setipripant, Histogen, and Replicel.

community Progress photo - 2 years on topical minoxidil.

6 upvotes 5 days ago

The user experienced crown thinning in their 30s and has been using topical minoxidil for 2 years with great regrowth results. Finasteride was not an option, and the user acknowledges minoxidil is not a permanent solution but is satisfied with the current hair stability.

community NEW PHOTOS- 10 MONTHS MARK - NW7 Diffuse going for the comeback. (49M)

216 upvotes 3 weeks ago

A 49-year-old man shared his 10-month hair recovery progress using finasteride 1.25mg and topical minoxidil 5%, noting significant improvement after initial worsening and emphasizing patience. He also mentioned weight loss and plans to continue the regimen until further evaluation.

community So why did the first pyrilutamide phase III fail?

4 upvotes 1 month ago

Pyrilutamide's inconsistent trial results, with phase II showing positive hair growth and phase III failing to show significant gains, possibly due to COVID-related disruptions. Users discuss modest results from kx-826 treatment.

community Pelage Pharmaceuticals posted a tweet about PP405.

41 upvotes 2 months ago

Pelage Pharmaceuticals' PP405 is discussed with skepticism about its effectiveness in hair regrowth, with some users expressing doubt and others hopeful but cautious. Treatments like finasteride are mentioned as current options, but there's a general sentiment that a cure for hair loss is not imminent.

community Shedding phase... It's brutal lol

in Progress Pictures 8 upvotes 4 months ago

The user is using finasteride and topical minoxidil for hair loss after previously trying them separately without success. They are experiencing a shedding phase but are committed to the treatment.

community Breezula Phase 3 Results enough for maintenance?

13 upvotes 4 months ago

Breezula shows promise in stabilizing hair loss and potentially promoting regrowth at the one-year mark, offering hope for those who can't tolerate 5AR inhibitors. Its local targeting of androgen receptors could be a significant advancement if it avoids systemic side effects.

community Progress photos 1month-3month comparison read description

in Progress Pictures 2 upvotes 4 months ago

The user experienced significant hair regrowth after starting treatment with 1.2mg finasteride and 5mg minoxidil in January 2026. They also reduced stress and stopped drug use, except for nicotine, which contributed to their progress.

community VDPHL01 phase-2/3 results comparison

in Research/Science 128 upvotes 4 months ago

The conversation discusses hair loss treatments, focusing on a new slow-release oral minoxidil compared to topical minoxidil and finasteride. The results show that twice-daily dosing of the new treatment is slightly more effective than once-daily, but concerns about cost, side effects, and the accuracy of reported results remain.

community Pelage Pharmaceuticals with an absolute stunner of a molecule

in Chat 4 months ago

PP405 is a promising new treatment for hair loss. It performs three actions in one, potentially offering a cure.

community Breezula Phase III 12-Month Data Released by Cosmo Pharma

42 upvotes 5 months ago

Clascoterone 5% topical solution is effective and safe for long-term use in treating male pattern hair loss. Cosmo Pharma aims for EU and US approval, with a potential US release in late 2027 or early 2028.

community Online Pharmacy that ships within the EU??

in Product 5 upvotes 5 months ago

The conversation is about finding an online pharmacy within the EU that sells oral minoxidil and finasteride. Recommendations include Justhair and Minoxidiexpress.

community Progress photos 5 years apart. .5mg dut/daily + 5mg oral min/daily

in Progress Pictures 6 upvotes 5 months ago

The conversation discusses hair loss treatment progress over five years using 0.5mg dutasteride daily and 5mg oral minoxidil daily. Users comment on the difficulty of assessing progress due to lighting and hair length differences, but note the hair looks good in both photos.

community Pelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Presented at the American Academy of Dermatology (AAD) Annual Meeting 2026 28th march

30 upvotes 5 months ago

Pelage Pharmaceuticals' PP405 aims to treat hair loss by reactivating dormant hair follicle stem cells, showing promising results in early trials. The company plans to present their findings at the American Academy of Dermatology Annual Meeting in 2026.

community Pelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Presented at the American Academy of Dermatology (AAD) Annual Meeting 2026

122 upvotes 5 months ago

PP405 shows promise in regenerating hair by activating dormant follicles. Other treatments like VDPHL01 and Breezula are also advancing, providing new hope for hair loss solutions.

community Progress photos ( Full protocol in description )

in Is this regrowth? 4 upvotes 7 months ago

The user is using 5% Minoxidil, a 1 mm derma stamp, Vitamin D3, Zinc, and anti-dandruff shampoo for hair regrowth. They plan to consider DHT blockers like finasteride in the future.

community Macro photos of progress - dutasteride + topical minoxidil : 3,5 months

in Progress Pictures 58 upvotes 7 months ago

A 30-year-old male with androgenic alopecia shows progress after using dutasteride (0.5 mg daily) and topical minoxidil (5% twice daily) for 3.5 months. Users suggest adding dermastamping for better results.

community Breezula Phase 3 confusion - did they change something?

8 upvotes 7 months ago

Breezula's phase 2 showed reduced efficacy after 6 months, but phase 3 had positive results, causing confusion about any changes made to the drug. There is frustration over the long timeline for hair loss treatments, with some users expressing more interest in other potential treatments like GT-20029.

community Both photos are 10 months apart

in Progress Pictures 193 upvotes 7 months ago

The user experienced hair regrowth using finasteride and minoxidil over 8 months, with noticeable improvements starting in June. They reported side effects like erectile dysfunction and flakes but continued treatment as the effects were not permanent.

community Clascoterone ph3 results ready

10 upvotes 9 months ago

Clascoterone 5% solution showed a 539% improvement in hair count compared to placebo, but the actual increase in hair growth is minimal. Users express skepticism about the effectiveness of hair loss treatments.

community GT20029 Phase 2 results are out

in Treatment 60 upvotes 9 months ago

GT20029 shows promising results for hair loss treatment, with potential approval in China by 2026 or 2027, but U.S. approval may take longer. It could serve as an alternative to finasteride, with a potentially better side effect profile.

community Clascoterone phase 3 results are out!

80 upvotes 9 months ago

Clascoterone phase 3 results show promising improvements in hair count, but concerns about high costs and lack of detailed data remain. Users compare it to existing treatments like Minoxidil and Finasteride, expressing skepticism about its accessibility and effectiveness.

community People are hyped about PP405 but what about Veradermics phase 2!

in Research/Science 39 upvotes 10 months ago

Veradermics' phase 2 trial of slow-release oral minoxidil shows promising hair regrowth with minimized side effects, gaining significant attention and funding. PP405 is also noted for its potential as a side-effect-free alternative.

community Pelage Pharmaceutical Raises 120 million to continue PP405 Research. Link inside.

in Research/Science 73 upvotes 11 months ago

Pelage Pharmaceutical raised $120 million to continue research on PP405, a promising hair loss treatment that showed a 20% increase in hair density in 31% of men during a Phase 2a trial. The treatment was well-tolerated, with no systemic absorption, and Phase 3 trials are planned for 2026.