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    Did you mean PDE4 inhibitors?
    Glossary PDE4 inhibitors

    block an enzyme to reduce inflammation and immune responses

    PDE4 inhibitors, also known as Phosphodiesterase 4 inhibitors or PDE4i, are a class of drugs that block the enzyme phosphodiesterase 4. This enzyme is involved in breaking down cyclic adenosine monophosphate (cAMP), a molecule that plays a crucial role in regulating inflammation and immune responses. By inhibiting PDE4, these drugs can help reduce inflammation and are used to treat conditions like psoriasis, chronic obstructive pulmonary disease (COPD), and certain types of alopecia.

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      community Hair Loss “Cure” for Inflammation: Topical Roflumilast

      in Research/Science  32 upvotes 8 months ago
      Topical roflumilast is effective for reducing inflammation in various scalp conditions like seborrheic dermatitis, psoriasis, and eczema, but not proven to stop scarring alopecia. Alternatives like apremilast and Vtama are also discussed for their anti-inflammatory benefits.

      community DHT Harms Scalp Microbiome: DHT Itch is REAL

       413 upvotes 1 year ago
      Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

      community Setipiprant/PGE2 feedbacks?

       4 upvotes 8 years ago
      The conversation discusses using PGE2 as a hair growth stimulant, comparing it to minoxidil, and considering the addition of Setipiprant. Concerns about side effects like skin damage and cost are also mentioned.

      community Pp405 full presentation on new topical

       106 upvotes 5 months ago
      A new topical treatment, PP405, shows promising results for hair regrowth, potentially outperforming existing treatments like finasteride and minoxidil. However, it may still need to be combined with DHT blockers for optimal results, and its long-term effectiveness remains uncertain.

      community Does anyone know of the actual effectiveness of the DP2 inhibitors?

       4 upvotes 8 years ago
      Setipiprant and Fevipiprant are questioned for their effectiveness in hair maintenance, with skepticism due to lack of convincing results beyond vellus hair growth. The user is satisfied with Minoxidil and Finasteride but is curious about the potential of DP2 inhibitors.

      community We need actual hair loss studies on Epristeride

      in Research/Science  6 upvotes 1 year ago
      Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalp DHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.

      community Increased efficacy of fin/dut: with or without meal?

       6 upvotes 4 months ago
      Taking dutasteride with a meal containing fat may improve absorption, but consistency in routine is more important than timing. Minor variations in absorption won't significantly affect efficacy due to dutasteride's long half-life.

      community Is Cialis the best option for when you have ED on DHT blockers?

      in Chat  61 upvotes 2 months ago
      The conversation discusses using finasteride for hair loss and its side effect of erectile dysfunction (ED), with some users suggesting reducing the dose to 0.5mg to minimize side effects. Cialis is recommended for managing ED, and other suggestions include monitoring hormone levels and considering supplements like DIM or L-Citrulline.

      community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

       3 upvotes 1 year ago
      DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

      community Pp405 phase 2a clinical results

       37 upvotes 1 year ago
      PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.

      community Has anyone tried Duodart (dutastride + tamsulosin)

       1 upvotes 5 months ago
      The conversation discusses using Duodart (dutasteride + tamsulosin) for hair loss, with side effects like frequent urination and ejaculation issues leading to discontinuation. The user switched to German Avodart and experienced mood and erection side effects, considering adjusting the dosage to three times a week.

      community Fluridil (Eucapil) seems like a great option?

       4 upvotes 9 months ago
      The user stopped using finasteride due to side effects and is considering Fluridil (Eucapil) as an alternative for hair loss treatment. They are exploring other options like RU58841 and are interested in the experiences of others with Fluridil, noting its good safety profile despite the cost.

      community 4 weeks in (dutasteride only).

      in Progress Pictures  76 upvotes 10 months ago
      A user experienced hairline improvement after four weeks on 1.5mg dutasteride but had side effects like reduced libido and sensitive nipples. They plan to switch to finasteride to manage these side effects.

      community So is this the actual trial results for pp405?????

       94 upvotes 5 months ago
      PP405 shows promising results for hair growth, potentially outperforming finasteride without side effects like erectile dysfunction. Users discuss using treatments like minoxidil, pyrilutamide, nizoral, and alfatradiol while waiting for PP405's availability.

      community Fluridil solution at Actifolic

       5 upvotes 3 years ago
      Fluridil, also known as Topilutamide or Eucapil, is discussed as a treatment for hair loss. It is noted as an androgen receptor antagonist, not a vasodilator.

      community Will PP405 render Minox and Fin obsolete?

       30 upvotes 1 year ago
      PP405 might make minoxidil unnecessary, but finasteride or other 5AR inhibitors may still be needed. PP405 is expected to be expensive and not available until at least 2028, with limited information on its effectiveness.

      community When should we get the next news about PP405

       24 upvotes 10 months ago
      Results for PP405 are expected next year, with concerns about its pricing and potential black market availability. Some users believe it may be slightly more effective than finasteride and dutasteride, and combining it with treatments like minoxidil and microneedling could be beneficial.

      community Can i use a dut with tamsulosin?

      in Product  3 upvotes 1 year ago
      The conversation is about using a product containing dutasteride and tamsulosin for hair loss. Users discuss separating the components and potential side effects like frequent urination and changes in libido.

      community Pelage PP405 Phase 2a completed.

       61 upvotes 7 months ago
      Minoxidil, finasteride, and RU58841 are discussed as treatments for hair loss, with excitement around a new drug, PP405, and a reformulated oral minoxidil in trials. Concerns about cost, side effects, and long-term use are also mentioned.

      community Oral PTD-DBM available online, worth giving a shot?

       4 upvotes 6 years ago
      Oral PTD-DBM was discussed as a potential hair loss treatment, but it was deemed ineffective in humans despite promising results in mice. The conversation concluded that trying it without VPA might be unwise.
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