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Did you mean Wnt/PCP pathway?

GlossaryNon-canonical Wnt Pathway (Wnt/PCP pathway)

regulates cell movement and organization without using β-catenin

The Non-canonical Wnt Pathway is a signaling pathway that operates independently of the β-catenin protein, which is central to the canonical Wnt pathway. This pathway is involved in regulating various cellular processes such as cell movement and organization, and it includes sub-pathways like the Wnt/PCP (Planar Cell Polarity) pathway and the Wnt/Ca2+ pathway. These pathways play crucial roles in embryonic development, tissue regeneration, and diseases, including certain types of alopecia.

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community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 46 upvotes 6 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community 4600 - result 9 month - Dr. Carman

in Progress Pictures 255 upvotes 9 months ago

A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 156 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community can someone please tell me its going to get better? im bawling my eyes out

in Female 67 upvotes 2 years ago

A 16-year-old girl is experiencing hair loss, which has worsened despite using minoxidil and multivitamins. Suggestions include broader hormone testing and considering other treatments like spironolactone if the hair loss is due to androgenic alopecia.

community I started rapidly diffuse thinning at 22. I'm 42 now and have as much hair as I did at 16. AMA

in Treatment 445 upvotes 4 years ago

Hair loss treatments like finasteride, minoxidil, ketoconazole, PRP, and microneedling helped maintain hair for 20 years. Research and try evidence-based treatments for best results.

community How do you get a dutasteride prescription in the U.S.?

in Finasteride/Dutasteride 18 upvotes 3 weeks ago

Dutasteride can be prescribed in the U.S. through online services like Dr. B, HiDrB.com, and PushHealth, or by finding a willing dermatologist or PCP. Many users report success with these methods, often at low costs with insurance.

community Primary Care Provider told me to not be concerned and just take biotin.

in Finasteride/Dutasteride 2 upvotes 1 month ago

A 19-year-old was advised by their primary care provider to take biotin for hair loss instead of minoxidil or finasteride due to potential side effects and age concerns. The user is considering seeking a second opinion from a dermatologist.

community Sharing what worked for me (PCOS related hair loss)

in Female 32 upvotes 10 months ago

A user with PCOS experienced hair loss and found success using a triple dose of O.N.E Omega by Pure Encapsulations after discovering low Omega fatty acids. Biotin provided minimal improvement, but the Omega supplement significantly restored hair.

community Hormones and hair loss (23F)

7 upvotes 8 years ago

The user is experiencing severe hair loss, possibly due to telogen effluvium, after stress, poor nutrition, and hormonal changes. They are using Nizoral and supplements but are considering hormonal treatments like spironolactone despite previous side effects.

community 3 months on dut plus oral min 5mg

in Is this regrowth? 383 upvotes 2 weeks ago

A user switched from finasteride and minoxidil to dutasteride and increased their oral minoxidil dose to 5mg daily, resulting in significant hair regrowth in three months. They stopped using tretinoin and reported minimal hair shedding and noticeable new hair growth.

community Key is to start early - 9 years on fin, about 10 months on oral min. Considering a hair transplant

in Progress Pictures 74 upvotes 5 months ago

A user shared progress pictures after 9 years on finasteride and 10 months on oral minoxidil, considering a small FUE hair transplant to fill in temple points. Replies praised the results, suggesting a transplant might not be necessary.

community 4 months progress / dut 0.5mg + topical min

in Progress Pictures 108 upvotes 9 months ago

The conversation is about someone's 4-month hair regrowth progress using 0.5mg dutasteride and topical minoxidil. Another person is inspired and is using 5mg finasteride and 5% minoxidil topically twice daily, hoping for similar results.

community xyon Fin progress photos - 9 months progress

in Progress Pictures 26 upvotes 10 months ago

User applied Xyon fin topical gel daily, used Augstinus Bader shampoo, conditioner, and scalp treatment, and applied argan oil twice a week. No Minoxidil, no dermarolling, and no side effects were reported.

community Anyone else growing tired of the finasteride wars?

in Finasteride/Dutasteride 169 upvotes 1 year ago

The conversation is about differing experiences with finasteride for hair loss, with some users reporting side effects and others not, and the debate over the drug's safety and effectiveness. Specific treatments mentioned include finasteride, dutasteride, and topical finasteride.

community Take this as a sign to start…Exactly 4 Months! (1mg Fin/5% minoxidil, nizoral) (28m)

in Progress Pictures 1112 upvotes 2 weeks ago

A 28-year-old experienced significant hair regrowth over four months using 1mg finasteride, 5% minoxidil, and Nizoral shampoo. The user reported no side effects except occasional dandruff and emphasized the importance of consistent application.

community 7mo of min 2.5mg, started fin 1mg yesterday. Both oral, both daily

in Progress Pictures 246 upvotes 1 month ago

A user shared their 7-month progress using oral minoxidil (2.5mg) and recently started finasteride (1mg) daily, reporting significant hair improvement without side effects. They noticed thicker beard growth and some hair thickening at the crown, with no shedding phase yet.

community 4 month update - nuclear stack, 42m

in Progress Pictures 257 upvotes 2 months ago

A 42-year-old user shared a 4-month update on their hair regrowth using a "nuclear stack" including oral and topical minoxidil, dutasteride, RU58841, micro-needling, keto shampoo, saw palmetto, biotin, multivitamins, scalp massages, and inversion table. They reported significant progress with minimal side effects and plan to continue the routine.

community Have been on treatment for close to two years, need to know if I should continue or take dut

in Progress Pictures 52 upvotes 2 months ago

A 22-year-old male has been using finasteride, topical minoxidil, and oral minoxidil for hair loss but sees minimal improvement and is considering adding dutasteride. Users suggest additional treatments like dermarolling, PRP, and consulting a dermatologist, or considering a hair transplant.

community 14 Month Progress w/ Topical Fin+Min

in Progress Pictures 978 upvotes 3 months ago

A user shared 14-month progress pictures using topical finasteride and minoxidil for hair loss. Others commented on the impressive results and asked about age, improvement timeline, and how to obtain finasteride.

community Is ketoconazole very effective?

in Ketoconazole 10 upvotes 5 months ago

A user is considering using ketoconazole shampoo for hair loss and is seeking feedback on its effectiveness. They are asking for before and after photos or success stories.

community No results with medications, now in contact with restoration clinic. Looking for advice on options - including facial hair.

in Transplants 3 upvotes 7 months ago

The individual has experienced no hair regrowth from using minoxidil and finasteride and is considering a hair restoration clinic's options, including PRP and nano follicle hair replacement, as well as a potential beard transplant. They are seeking advice on whether to pursue PRP, timing for hair replacement surgery, and experiences with beard transplants.

community do any supplements actually work?

in Female 6 upvotes 8 months ago

A user asked if collagen or hair growth supplements made their hair thicker. Another user suggested that Vitamin D might help if deficient.

community 8 months on 5mg fin daily, 5% min twice daily, and hrt(mtf). Thought my hair was unrecoverable before but now I’m so happy.

in Transgender 1896 upvotes 1 year ago

A user named "LordGeek101" shared their positive experience with hair regrowth after using 5mg of finasteride daily, 5% minoxidil twice daily, and hormone replacement therapy (HRT) for 8 months. The user is transgender (MTF) and mentioned that the larger dose of finasteride was recommended by their doctor for better chances of hair revival.

community Which vitamin deficiencies can lead to hair loss?

in Chat 69 upvotes 1 year ago

The conversation discusses potential vitamin deficiencies leading to hair loss, with a focus on Vitamin D and iron. Some individuals are using finasteride and minoxidil for hair loss, while others consider vitamin supplementation due to deficiencies.

community Made the switch to Dutasteride

in Finasteride/Dutasteride 31 upvotes 1 year ago

User switched from Finasteride to Dutasteride and oral Minoxidil after dermatologist's recommendation. Others in conversation express interest and support for the new treatment.

community Finasteride/dut. causes NAFLD,IR,diabetes,kidney dysfunction is it correct.

in Finasteride/Dutasteride 139 upvotes 1 year ago

Hair loss discussion mentions treatments like Finasteride, Dutasteride, and Minoxidil. Users share experiences, side effects, and advice on using these treatments.

community Still shedding like this everyday 9 months straight on fin and min. Should I switch to dut?

in Finasteride/Dutasteride 54 upvotes 2 years ago

A user reporting an extended shedding period of 9 months while using finasteride and minoxidil, and other users offering advice on treatments such as dutasteride, multivitamin, biotin, rosemary oil, Kiel's magic elixir, hair extensions, changing hair color, healing crystals, and seeing a dermatologist.

community Finasteride + Minoxidil + Ketozolin Shampoo + Vitamin D and Biotin results

in Progress Pictures 320 upvotes 2 years ago

So maybe vitamin D is important here This conversation discussed the user's successful results from a combination of treatments, including finasteride, minoxidil, ketozolin shampoo, Vitamin D and biotin. The discussion also included advice about frequency and dosages for these treatments.

community Please listen. If you want to save your hair.

in Progress Pictures 126 upvotes 2 years ago

User discusses two medications for stopping hair loss: Fin (finasteride) and Dut (dutasteride). Mixed experiences and side effects are shared, with some users seeing positive results.

community Fuck hair loss; acquire beard.

in Shaved/buzzed 933 upvotes 2 years ago

A user's transformation from an accountant to a spartan with a full beard, discussing the potential of DUPA and alopecia areata, as well as treatments like vitamins, topicals, and natural treatments for potential regrowth.