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GlossaryNonsteroidal Anti-Inflammatory Drugs

reduce inflammation, pain, and fever without using steroids

Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are a class of medications that reduce inflammation, relieve pain, and lower fever. Unlike steroids, they do not contain corticosteroids. Common examples include ibuprofen and aspirin. They work by inhibiting enzymes called COX-1 and COX-2, which are involved in the production of prostaglandins, compounds that promote inflammation, pain, and fever.

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community Medications that cause extra hair growth

in Research/Science 123 upvotes 1 year ago

The post discusses the side effects of various drugs causing excess hair growth, questioning why only minoxidil is used in the hair loss industry. The conversation includes users sharing their experiences and concerns about potential side effects of these drugs, with some preferring baldness over potential health risks.

community So we’re just ok with taking a research chemical now?

in Treatment 179 upvotes 3 years ago

The conversation discusses the use of RU58841, a non-FDA approved research chemical for hair loss, with mixed opinions on its safety and effectiveness. Some users are willing to try it as a last resort after other treatments like Minoxidil and Finasteride failed, while others express concerns about potential long-term side effects and lack of official research.

community KX-826 Pyrilutamide1% coming soon

in Update 152 upvotes 4 months ago

KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

community Binding affinity of pyrilutamide!

in Update 167 upvotes 2 years ago

Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

community First people receive Pyrilutamide March 19th 2022!

in Treatment 129 upvotes 2 years ago

First people receive Pyrilutamide on March 19th, 2022 for hair loss treatment. Users discuss obtaining the drug, its patent, and potential group buys.

community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

in Treatment 21 upvotes 9 months ago

Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

community Pyrilutamide six months update{ New Progress Pics}

in Progress Pictures 322 upvotes 1 year ago

A user shared a six-month update on hair improvement using Pyrilutamide and Minoxidil, noting significant hair regrowth and strength. Some participants questioned the legitimacy of the results and the source of Pyrilutamide.

community Anyone else crying themselves to sleep because of the pyrilutamide fail?

in Technology 41 upvotes 1 year ago

The conversation is about disappointment with pyrilutamide's performance as a hair loss treatment, with some users expressing interest in other treatments like Verteporfin, GT20029, and RU58841, while others suggest sticking with established treatments like finasteride or dutasteride.

community Does anyone use Fluridil as their anti-androgen of choice?

in Chat 6 upvotes 1 year ago

Fluridil, a non-steroidal anti-androgen approved for alopecia in parts of Europe, is noted for its low side effects but is not commonly discussed. The user is inquiring if anyone prefers it over other anti-androgens like Spiro or RU58841.

community Losing hair for 3 years (24 yrs old)

in Chat 26 upvotes 3 years ago

User losing hair for 3 years tried shampoos, minoxidil, derma rolling, finasteride, and Adegen's 15% minoxidil protocol without success. Another user suggests lowering finasteride dosage and trying topical non-steroidal anti-androgens like Fluridil, RU58841, and Breezula.

community Just a little update. RU, minox, and Dut

in Progress Pictures 1078 upvotes 2 years ago

User discusses hair regrowth using RU58841, minoxidil, and dutasteride. Many users praise the progress and ask about the treatments' effectiveness and side effects.

community 26, i was cool w shaving bald but I wanted to hold on for a little longer. Just topical min and rosemary shampoo.

in Progress Pictures 688 upvotes 1 year ago

The post and conversation are about a user's successful regrowth of hair using topical minoxidil and rosemary shampoo. Other users discuss the potential limitations of minoxidil and recommend using finasteride to maintain hair growth.

community Anagen is now selling pyrilutamide

in Product 139 upvotes 2 years ago

Pyrilutamide, a potential hair loss treatment that has recently been released for sale, and is thought to have similar efficacy to Dutasteride without side effects. It was discussed in terms of its effectiveness compared to Finasteride, its use by females, and whether it can be safely mixed with RU58841.

community Possible explaination for Finasteride Reflex Hyperandrogenicity

in Finasteride/Dutasteride 6 upvotes 2 years ago

The user has been using finasteride and minoxidil for hair loss but experienced worsening temple recession. They suspect they might be more sensitive to testosterone and are considering trying RU58841 or CB 03 01 as additional treatments.

community If Ru58841 was an FDA approved medication and known to be safe would you recommend it before finasteride?

in Product 7 upvotes 1 year ago

The conversation discusses whether RU58841, if FDA approved and safe, would be recommended over finasteride for hair loss. Specific treatments mentioned include RU58841, finasteride, and minoxidil.

community Pyrilutamide phase III clinical trial results released

in Research/Science 31 upvotes 1 year ago

Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

community It's over. Hairline has fallen. Millions must shave.

in Update 467 upvotes 1 year ago

The conclusion of the conversation is that the user has tried various medications and treatments for hair loss, including minoxidil, finasteride, microneedling, and nizoral shampoo, but has not seen any progress. They have decided to shave their head. Other users suggest options such as hair transplants, RU58841, hair units, and scalp micropigmentation.

community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 9 months ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Pyrilutamide PHASE 2 Results just one months to go. Are you excited???🤩

in Research/Science 96 upvotes 2 years ago

Pyrilutamide, a potential topical treatment for male pattern baldness, and the user's anticipation of its Phase 2 trial results. Several users discussed their experiences with Finasteride and RU58841, while others voiced skepticism about the efficacy of Pyrilutamide.

community 8.5 month progress of min/fin/RU

in Progress Pictures 64 upvotes 3 years ago

The conversation discusses an 8.5-month progress of using Minoxidil, Finasteride, and RU58841 for hair loss. People are complimenting the user on the significant improvement in hair thickness.

community Why do I have the feeling that this subreddit is flooded by Kintor employees?

in Chat 132 upvotes 3 months ago

Users discuss aggressive promotion of Koshine 826, suspecting Kintor employees are behind it. Concerns are raised about its effectiveness, with some preferring alternatives like finasteride and minoxidil.

community 3 Month Results with Nuclear Stack - 42M

in Progress Pictures 109 upvotes 3 months ago

A user shared 3-month hair regrowth results using a combination of oral Dutasteride, daily Minoxidil, RU58841, micro-needling, Keto shampoo, scalp massages, and supplements. Positive progress was noted, and encouragement to continue was given.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 138 upvotes 5 months ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Pyrilutamide is available at Minoxidilmax

in Research/Science 58 upvotes 2 years ago

Minoxidilmax offering a 0.5% Pyrilutamide solution and debating the cost, effectiveness, and safety of using it alone or with other treatments such as Finasteride and Minoxidil.

community Treatments to maintain alternative to finasteride/dutasteride

in Treatment 6 upvotes 3 years ago

A 29-year-old male experiencing hair loss due to TRT is using minoxidil and dermarolling but is hesitant to use finasteride or dutasteride due to potential side effects. He is considering low level laser therapy (LLLT), PRP, ketoconazole shampoo, and oral minoxidil as additional treatments. A reply suggests that without a DHT blocker like finasteride or dutasteride, other treatments may not be effective long-term.

community 15 months total on Dut/Min/RU and microneedling 1mm every other week

in Progress Pictures 1761 upvotes 3 months ago

The user reported significant hair improvement over 15 months using dutasteride, minoxidil (oral and topical), RU58841, ketoconazole, and microneedling. They are considering a hair transplant in 4-6 months.

community Minox. 2.5 percent, Finasteride 1.25mg, Microneedling 1.5 mm, Ketoconazole shampoo and Biotin. Got better until it didn’t. Should I start dutasteride and Ru?

in What should I do? 90 upvotes 3 years ago

User experiencing hair loss tried Minoxidil, Finasteride, Microneedling, Ketoconazole shampoo, and Biotin. Others suggest continuing current treatment for 1-2 years before considering Dutasteride and RU58841.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 336 upvotes 1 year ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.

community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 11 months ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community What’s more reliable right now, pyrilutamide or RU?

in Treatment 15 upvotes 2 years ago

Treatments for hair loss, with the user considering Pyrilutamide and RU58841 as options. It is noted that although Pyrilutamide has been studied more and is allegedly more effective, there are doubts about its authenticity in the market. KX-826 is suggested as an alternative as it has a stronger effect than RU58841 and there is scientific research on it.