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    GlossaryNonsteroidal Anti-Inflammatory Drugs

    reduce inflammation, pain, and fever without using steroids

    Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) are a class of medications that reduce inflammation, relieve pain, and lower fever. Unlike steroids, they do not contain corticosteroids. Common examples include ibuprofen and aspirin. They work by inhibiting enzymes called COX-1 and COX-2, which are involved in the production of prostaglandins, compounds that promote inflammation, pain, and fever.

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      community Medications that cause extra hair growth

      in Research/Science  119 upvotes   10 months ago
      The post discusses the side effects of various drugs causing excess hair growth, questioning why only minoxidil is used in the hair loss industry. The conversation includes users sharing their experiences and concerns about potential side effects of these drugs, with some preferring baldness over potential health risks.

      community So we’re just ok with taking a research chemical now?

      in Treatment  176 upvotes   3 years ago
      The conversation discusses the use of RU58841, a non-FDA approved research chemical for hair loss, with mixed opinions on its safety and effectiveness. Some users are willing to try it as a last resort after other treatments like Minoxidil and Finasteride failed, while others express concerns about potential long-term side effects and lack of official research.

      community Binding affinity of pyrilutamide!

      in Update  172 upvotes   2 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community RU-58841 Lung Disease Possibility | Chest pain, "heart issues", etc

      in Treatment  23 upvotes   5 months ago
      Some users of RU-58841 report cardiovascular symptoms like heart palpitations and chest tightness, which may be linked to its metabolites causing lung disease. The safety of RU-58841 is uncertain due to lack of long-term data and concerns about product purity, especially from gray market sources.

      community Pyrilutamide six months update{ New Progress Pics}

      in Progress Pictures  321 upvotes   1 year ago
      A user shared a six-month update on hair improvement using Pyrilutamide and Minoxidil, noting significant hair regrowth and strength. Some participants questioned the legitimacy of the results and the source of Pyrilutamide.

      community Anyone else crying themselves to sleep because of the pyrilutamide fail?

      in Technology  41 upvotes   8 months ago
      The conversation is about disappointment with pyrilutamide's performance as a hair loss treatment, with some users expressing interest in other treatments like Verteporfin, GT20029, and RU58841, while others suggest sticking with established treatments like finasteride or dutasteride.

      community Does anyone use Fluridil as their anti-androgen of choice?

      in Chat  6 upvotes   8 months ago
      Fluridil, a non-steroidal anti-androgen approved for alopecia in parts of Europe, is noted for its low side effects but is not commonly discussed. The user is inquiring if anyone prefers it over other anti-androgens like Spiro or RU58841.

      community Losing hair for 3 years (24 yrs old)

      in Chat  26 upvotes   3 years ago
      User losing hair for 3 years tried shampoos, minoxidil, derma rolling, finasteride, and Adegen's 15% minoxidil protocol without success. Another user suggests lowering finasteride dosage and trying topical non-steroidal anti-androgens like Fluridil, RU58841, and Breezula.

      community Anagen is now selling pyrilutamide

      in Product  140 upvotes   2 years ago
      Pyrilutamide, a potential hair loss treatment that has recently been released for sale, and is thought to have similar efficacy to Dutasteride without side effects. It was discussed in terms of its effectiveness compared to Finasteride, its use by females, and whether it can be safely mixed with RU58841.

      community Pyrilutamide phase III clinical trial results released

      in Research/Science  33 upvotes   8 months ago
      Pyrilutamide did not show effectiveness in regrowing hair compared to a placebo, but it may still help maintain existing hair by preventing DHT from causing follicle miniaturization. Some users believe it could be beneficial when used with other treatments like minoxidil, finasteride, and dutasteride.

      community It's over. Hairline has fallen. Millions must shave.

      in Update  467 upvotes   1 year ago
      The conclusion of the conversation is that the user has tried various medications and treatments for hair loss, including minoxidil, finasteride, microneedling, and nizoral shampoo, but has not seen any progress. They have decided to shave their head. Other users suggest options such as hair transplants, RU58841, hair units, and scalp micropigmentation.

      community Is this broscience? From More Plates, More Dates

      in Research/Science  21 upvotes   5 months ago
      The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

      community 8.5 month progress of min/fin/RU

      in Progress Pictures  61 upvotes   3 years ago
      The conversation discusses an 8.5-month progress of using Minoxidil, Finasteride, and RU58841 for hair loss. People are complimenting the user on the significant improvement in hair thickness.

      community Treatments to maintain alternative to finasteride/dutasteride

      in Treatment  6 upvotes   2 years ago
      A 29-year-old male experiencing hair loss due to TRT is using minoxidil and dermarolling but is hesitant to use finasteride or dutasteride due to potential side effects. He is considering low level laser therapy (LLLT), PRP, ketoconazole shampoo, and oral minoxidil as additional treatments. A reply suggests that without a DHT blocker like finasteride or dutasteride, other treatments may not be effective long-term.

      community What’s more reliable right now, pyrilutamide or RU?

      in Treatment  15 upvotes   1 year ago
      Treatments for hair loss, with the user considering Pyrilutamide and RU58841 as options. It is noted that although Pyrilutamide has been studied more and is allegedly more effective, there are doubts about its authenticity in the market. KX-826 is suggested as an alternative as it has a stronger effect than RU58841 and there is scientific research on it.

      community Finally about to start Pyriltamide (ONLY Pyriltamide)

      in Chat  60 upvotes   1 day ago
      A user is excited to start using Pyriltamide for hair loss after experiencing side effects from topical finasteride. Other users discuss the potential and skepticism of Pyriltamide compared to older treatments like finasteride and RU58841.

      community 3 month progress NW5 -- lost cause?

      in Progress Pictures  22 upvotes   1 year ago
      A user is treating their advanced hair loss with a regimen including topical finasteride, minoxidil, hydrocortisone, stem cell serum, peptide serum, multivitamins, he shou wu tea, derma pen, argan oil, and a derma roller. Replies suggest it's too early to judge progress and recommend staying consistent, with one suggesting oral minoxidil as an additional option.

      community Ru58841 ruined my life. Here’s why.

      in Product  128 upvotes   2 years ago
      User experienced shortness of breath, high blood pressure, red eyes, and eye floaters after using RU58841 for hair loss. They warn others to avoid RU58841 and stick to finasteride, minoxidil, and dutasteride.