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Glossary Nonsense Mutation

change in DNA introduces a premature stop codon

A nonsense mutation, also known as a premature stop codon or termination mutation, is a change in the DNA sequence that introduces a stop codon where there shouldn't be one. This causes the protein synthesis process to halt prematurely, resulting in a truncated and usually nonfunctional protein. This type of mutation can lead to various genetic disorders, including some forms of alopecia, by disrupting the normal function of essential proteins.

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community Is Vitamin D the cause of my baldness or slow regrowth?

in Is this regrowth? 1 upvotes 10 months ago

The conversation discusses hair loss treatments, including oral finasteride, topical minoxidil, and microneedling, and the potential impact of Vitamin D and folic acid deficiencies on hair regrowth. It suggests that while male pattern baldness is the primary cause, addressing vitamin deficiencies may aid in improving regrowth.

community We need to keep these snake oil companies accountable.

in Treatment 120 upvotes 2 years ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community If PP405 goes systemic this would be quite catastrophic

in Research/Science 4 upvotes 1 year ago

Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

community How significant is the difference between 0.5mg Dut and 1mg Fin?

in Finasteride/Dutasteride 11 upvotes 2 years ago

0.5mg dutasteride reduces scalp DHT more than 1mg finasteride, leading to better hair regrowth results. Users report significant improvement with dutasteride compared to finasteride.

community Dutasteride causing us to have… girl babies?

in Finasteride/Dutasteride 26 upvotes 3 years ago

User Kylo313 used dutasteride for 20 years and had two daughters, questioning if dutasteride affects the likelihood of having male vs female children. Replies mostly request hairline photos and discuss anecdotal experiences, with some suggesting correlation doesn't imply causation and that gender determination isn't affected by dutasteride.

community Been on Dut since 2022, new doctor has concerns.

15 upvotes 4 months ago

A 31-year-old man has been using Dutasteride since 2022, alongside topical Minoxidil, with positive results and no issues. His new healthcare provider expressed concerns about long-term Dutasteride use and suggested alternatives like oral Minoxidil and Spironolactone, but the patient is hesitant to change a successful routine.

community Why don't we all just take 2.5mg dutasteride?

in Finasteride/Dutasteride 45 upvotes 11 months ago

Switching from finasteride and minoxidil to a higher dose of dutasteride for hair loss is debated due to potential side effects. Many suggest starting with lower doses or sticking to finasteride if effective.

community If we can clone a sheep why we can't cure baldness till now

in Research/Science 181 upvotes 1 year ago

Hair loss treatments like Minoxidil, finasteride, and stem cell therapies exist, but a complete cure is hindered by genetic complexity and market dynamics. Cloning hair follicles is considered a potential solution, but it's currently not feasible.

community When you start balding you notice how unnatural this phenomenon is

532 upvotes 1 year ago

Hair loss is a common issue, with treatments like finasteride and minoxidil used but not as permanent cures. Frustration exists over societal perceptions and the lack of a definitive solution.

community Do natural remedies actually work or it is nonsense?

in Chat 3 upvotes 5 months ago

Natural remedies may improve hair and scalp health but do not stop hair loss related to DHT or other imbalances. Proven treatments like Minoxidil and Finasteride are recommended for effective results.

community LLLT Laser Hair Loss Treatment – Tried It at 30, And Here's My Experience

8 upvotes 11 months ago

The user tried LLLT laser treatment for hair loss, noticing less hair shedding and thicker hair after six months, emphasizing consistency and gentle scalp care. Other users questioned the authenticity of the post and inquired about the frequency and type of device used.

community Other factors involved then DHT/5aR

5 upvotes 3 months ago

DHT is the primary cause of hair loss, but factors like diet, stress, and lifestyle can influence its severity. Treatments like finasteride and dutasteride target DHT, while maintaining overall health is also important.

community 2.5 Months on Dutasteride and 5% topical Minoxidil

151 upvotes 4 months ago

The user experienced increased sex drive and financial cost after 2.5 months on Dutasteride and 5% topical Minoxidil. They advise starting treatment early to prevent hair loss and mention that side effects are minimal, with Dutasteride having a longer-lasting presence in the system compared to Finasteride.

community Shedding increase from pumpkin seed oil - dread shed or time to stop?

in Female 8 months ago

A user experienced increased hair shedding after taking pumpkin seed oil for 4 weeks and is unsure if it's a "dread shed" or if the oil isn't suitable. They cannot tolerate anti-androgens like spironolactone and finasteride due to side effects and are seeking advice on whether to continue with pumpkin seed oil.

community Need a transplant? Currently taking minoxidil, saw palmetto and pumpkin seed oil.

in Is this regrowth? 12 upvotes 11 months ago

The user is considering a hair transplant while currently using minoxidil, saw palmetto, and pumpkin seed oil. Others suggest using finasteride or dutasteride for better results and to prevent further hair loss.

community Been on min + fin + dut for 3 minutes.... is this progress? (Before vs after)

37 upvotes 11 months ago

A humorous take on hair loss treatments, mentioning the use of minoxidil, finasteride, dutasteride, and unconventional methods. The conversation includes satire about extreme and fictional hair growth rituals.

community Is the Cecred line actually legit or are people lying to us?

1 year ago

Cecred hair drops, containing keratin and biotin, are questioned for their effectiveness compared to proven treatments like minoxidil. Users express skepticism, suggesting deceptive marketing and the possibility of undisclosed use of other treatments like finasteride.

community 7 months dutasteride(1 mg) progress

in Progress Pictures 76 upvotes 1 year ago

Dutasteride, at 1 mg daily, was used for hair regrowth, with initial shedding and side effects like watery semen and increased libido. The user previously tried finasteride and minoxidil but switched to dutasteride for stronger, sustained results.

community Will PP405 render Minox and Fin obsolete?

30 upvotes 1 year ago

PP405 might make minoxidil unnecessary, but finasteride or other 5AR inhibitors may still be needed. PP405 is expected to be expensive and not available until at least 2028, with limited information on its effectiveness.

community Stop Complaining about Creatine. You're just fixated on shedding.

73 upvotes 1 year ago

Creatine is unlikely to cause hair loss as it does not raise DHT levels. Hair loss is more likely due to genetics, medications, or lifestyle changes.

community Creatine in People Who Take DHT

87 upvotes 1 year ago

Finasteride users have mixed experiences with creatine; some experience increased hair loss, while others do not. Finasteride's DHT-blocking effects might counteract any DHT increase from creatine, but individual responses vary.

community PSA: Fin/Dut are NON-NEGOTIABLE

in Finasteride/Dutasteride 688 upvotes 1 year ago

Finasteride and dutasteride are essential for stopping hair loss, while natural remedies are ineffective. Minoxidil can be added if needed, but blocking DHT is crucial.

community I asked chatgpt to roast tressless

in Satire 347 upvotes 2 years ago

The conversation humorously critiques hair loss treatments and the subreddit r/tressless. It mentions Minoxidil and finasteride as common treatments, with users reacting to a satirical roast by ChatGPT.

community 12 Month Progress w/ Topical Fin+Min

in Progress Pictures 171 upvotes 2 years ago

User shared 12-month progress using topical 0.25% finasteride and 5% minoxidil daily. Most replies suggest waiting longer for potential further regrowth before considering a hair transplant.

community A warning to those using or thinking about using Dutasteride – Follow-up

18 upvotes 5 years ago

The post and conversation are about the long-term side effects of using Dutasteride and Finasteride for hair loss, including issues like raised liver enzymes, high cholesterol, and loss of libido. The user advises regular blood work and careful monitoring for those using these treatments.

community Do PUFA's accelerate hair loss? Is this tweet accurate?

4 months ago

PUFA foods like salmon and walnuts are healthy and do not accelerate hair loss. There is no evidence linking PUFAs to hair loss, and claims suggesting otherwise lack scientific support.

community DHT is NOT very important for adults, is it?

124 upvotes 4 months ago

A user experienced negative side effects, including low libido and lack of motivation, after using finasteride for hair loss and felt better after stopping it. Others shared similar experiences with finasteride and dutasteride, while some reported no side effects, showing varied individual responses.

community Anybody used Fluridil ? Is my last hope.

4 upvotes 3 years ago

The conversation is about alternatives to finasteride for hair loss, with suggestions including fluridil, oral minoxidil, alfatradiol, and cb-03-01. Concerns about finasteride's side effects, including potential breast cancer risk, are also discussed.

community "nuked libido" does that mean 0 erections or just less horny?

5 upvotes 1 week ago

The user discusses experiencing changes in libido and erections while on finasteride, noting that supplements like tongkat, citrulline, arginine, zinc, and vitamin D help maintain morning erections. Other users share varied experiences with finasteride, with some reporting reduced libido and weaker erections, while others notice no significant changes.

community 19yo - 3 months vs 9 months on dut+min

215 upvotes 2 weeks ago

A 19-year-old shared their positive results after 9 months using topical minoxidil and dutasteride for hair loss. They started with twice-daily minoxidil applications, later reducing to once daily, and took 0.5mg of dutasteride.