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GlossaryMatrix Metalloproteinases

enzymes that degrade extracellular matrix proteins

Matrix Metalloproteinases (MMPs) are a group of enzymes that break down proteins in the extracellular matrix, which is the network of molecules surrounding cells. They play a crucial role in tissue remodeling, wound healing, and various physiological processes, but their overactivity can contribute to diseases like arthritis and cancer.

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community This serum outperformed Minoxidil in a recent study. Please debunk

23 upvotes 4 years ago

A topical solution called "Multi-Peptide Serum for Hair Density" by The Ordinary Company, which contains several ingredients that are used in alternatives to Minoxidil and was found to have better results than 5% Minoxidil in a study. People who have tried it shared their experiences with the serum as well.

community has anyone tried rubbing receipt paper on their heads as a free topical antiandrogen?

in Satire 51 upvotes 3 weeks ago

This post and conversation are about using receipt paper as a satirical treatment for hair loss. Users humorously discuss various absurd methods, including rubbing, ingesting, and making suppositories out of receipts.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 1 month ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community Best Treatment In The Pipeline?

in Chat 16 upvotes 3 months ago

New treatments for AGA are emerging, including pyrilutumide, gt0029, scube3, kx-826, and pp405. Verteporfin is mentioned as a promising option.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 158 upvotes 9 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community Has anyone else seen this encouraging verteporfin case study?

in Progress Pictures 37 upvotes 9 months ago

The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.

community Tropoelastin injections + verteporfin?

in Research/Science 12 upvotes 1 year ago

The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

community I am RESTLESS and not STRESSLESS due to my issues of TRESSLESS :(

in Female 15 upvotes 3 years ago

A female user is experiencing severe hair loss, especially at the crown and front, with broken and dull hair despite using Moroccan oil, shea moisture shampoo, and coconut oil. She seeks recommendations for a clinic or doctor as previous doctors attributed the issue to stress but offered no solutions.

community Sandalore: a scientific homemade approch

20 upvotes 5 years ago

The post discusses using Sandalore as a potential hair loss treatment, emphasizing precise measurements and safe handling. The user compares Sandalore's effects to Minoxidil and mentions preparing a solution with ethanol and DMSO.

community Do you think these will work? Some of these companies claim to have a cure by 2019-2025

8 upvotes 6 years ago

The conversation discusses the potential effectiveness of hair loss treatments, with some companies claiming to have a cure by 2019-2025. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

community Tristan Tate stopped using fin i guess???

in Satire 468 upvotes 1 month ago

Tristan Tate's hair loss is discussed, with mentions of finasteride, minoxidil, and dutasteride as treatments. Users speculate on his hair styling, steroid use, and legal troubles.

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

in Research/Science 76 upvotes 2 months ago

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 70 upvotes 2 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community microneedle, any long term users damage?

in Microneedling 35 upvotes 4 months ago

Microneedling is effective for hair growth, especially when combined with finasteride and minoxidil, but concerns exist about potential long-term skin damage. Users report increased collagen and elastin deposition, but the long-term effects on the scalp remain uncertain.

community What if I told you you could have it all back? May 2023 to now

in Progress Pictures 156 upvotes 9 months ago

The conversation is about a user's 7-month hair regrowth progress using finasteride/minoxidil gel, minoxidil foam, ketoconazole shampoo, thickening shampoo and conditioner, biotin supplements, and plans to start using a dermaroller. Replies suggest a new haircut and commend the user's progress.

community Mark Normand talks about finasteride experience

in Finasteride/Dutasteride 822 upvotes 1 year ago

The conversation is about hair loss and the use of finasteride as a treatment. Some users share their positive experiences with finasteride, while others mention side effects they have experienced.

community 4.5 Months on oral dut 0.5mg, oral min 5mg, topical RU 80mg, weekly microneedling at 1.5mm

in Progress Pictures 82 upvotes 1 year ago

User tried oral dut 0.5mg, oral min 5mg, topical RU 80mg, and weekly microneedling at 1.5mm for hair loss. Others commented on the significant improvement and potential for future hair transplant.

community Actor Patrick Stewart, 82, has a receding hairline. I thought it was pretty cool to see an older actor being successful, despite dealing with hair loss. He’s been knighted by Queen Elizabeth II and just voted “Sexiest Man Alive” by Glamour for the second time

in Satire 1 year ago

Actor Patrick Stewart's success despite having a receding hairline, how hair loss may not be as crippling as it is perceived to be, and how different people are attracted to different physical features.

community “Guys, am I norwood 3? Should I take fin?”

in Satire 446 upvotes 1 year ago

Hair loss, and treatments such as finasteride and oral minoxidil being discussed. Some people shared stories of their personal experiences while others gave humorous replies.

community Is it time for my 3-Year Old Nephew to get on Fin & Min? 😓

in Satire 517 upvotes 1 year ago

Hair loss in a 3-year-old, with various treatments discussed such as minoxidil, finasteride, dutasteride, RU58841 and biotin supplementation. Some people suggested shaving the head and growing a beard or getting a partial hairpiece instead of attempting to treat it.

community Why Is Only Tressless Talking About Verteporfin? Healing Wounds With Zero Scarring Has Gargantuan Implications For All of Medicine. So What Gives?

in Research/Science 18 upvotes 1 year ago

The potential of verteporfin to heal wounds without scarring; however, despite its promising preclinical trials and coverage from a major media outlet, there is still no official clinical trial result and the drug has only garnered attention from hair loss communities.

community 2.5 yrs progress: Min + dermaroll + niz

in Progress Pictures 74 upvotes 1 year ago

A user's 2.5 year hair loss progress with Minoxidil, dermarolling, and Nizoral treatments, as well as taking biotin and a multivitamin supplement, with the intention of trying DIY topical finasteride in the future.

community For those of you who are getting facial skin side effects (aging, dark circles) from minoxidil, try this, it helped me.

in Minoxidil 11 upvotes 3 years ago

The conversation provides tips to reduce facial skin side effects from Minoxidil, such as changing pillowcases, sleeping on the back, careful application, hydration, and taking breaks. One reply suggests that alcohol in Minoxidil formulations, not Minoxidil itself, may cause skin aging.

community Well… I Did It. Estrogen Saved My Hairline

in Transgender 700 upvotes 2 weeks ago

OP transitioned and used Spironolactone, Estradiol Valerate, Minoxidil, and dermarolling, resulting in significant hair regrowth. They advise this method may not be suitable for cis men.

community Dental technician is convinced that he has found the cause of pattern hair loss

in Research/Science 312 upvotes 1 month ago

A dental technician claims malocclusion causes pattern hair loss due to poor scalp circulation. Users debate this, noting treatments like finasteride, minoxidil, and microneedling focus on DHT and blood flow.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 1 month ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 5 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community Killing the Norwood Reaper, a Journey

in Progress Pictures 371 upvotes 6 months ago

The user is treating hair loss with a regimen including Dutasteride, oral and topical Minoxidil, microneedling, and various supplements for overall health. They are considering adding tretinoin, stemoxydine/RU, DIM, Boron, and Fadogia Agretis to their routine.

community 2 months and half progress. Just take the f*cking pill. (Completely wet hair)

in Progress Pictures 315 upvotes 1 year ago

User shares 2.5-month progress with hair loss pill, others discuss their experiences and results. Some mention using Minoxidil, Finasteride, and microneedling for hair regrowth.

community I will have it cured by morning

in Research/Science 370 upvotes 1 year ago

Researching the cause of hair loss and treating it by preventing DHT in the scalp with medication such as finasteride or dutasteride, estrogen, minoxidil, dermarolling, and possible topical antiandrogens.