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GlossaryExtracellular Signal-Regulated Kinase (MAPK)

protein that transmits signals from cell surface to DNA

Extracellular Signal-Regulated Kinase (ERK) is a type of protein kinase that plays a crucial role in the MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It helps transmit signals from the cell surface to the DNA in the cell nucleus, influencing processes like cell division, differentiation, and survival. This pathway is important in various biological functions and can be implicated in conditions like cancer and alopecia when dysregulated.

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community Next month marks 2 years on Dutasteride. When does it start working?

in Finasteride/Dutasteride 36 upvotes 6 months ago

A user has been on dutasteride for nearly 2 years with no improvement in hair loss, expressing frustration. Other users suggest checking for other health conditions, getting bloodwork, and considering stopping TRT or trying finasteride.

community Did anyone try natural hair masks while on Finasteride?

in Finasteride/Dutasteride 2 upvotes 1 year ago

The conversation is about using natural hair masks like red hot pepper, aloe vera, onion juice, mint oil, and valerian root alongside finasteride for hair loss. The user is asking if anyone has tried these and seen positive effects.

community Did anyone try natural hair masks while on Finasteride?

in Finasteride/Dutasteride 1 upvotes 1 year ago

community Dr. Maksim Plikus Putting in the Work!

in Progress Pictures 4 upvotes 1 year ago

The conversation discusses new research on hair growth by Dr. Maksim Plikus, with a call for clinical trials to begin. No specific treatments are mentioned.

community New company Amplifica gets $11.8 million in financing for development of its hair loss products. Dr. Maksim Plikus and William Rassman are co-founders.

in Update 27 upvotes 2 years ago

New company Amplifica receives $11.8 million for hair loss product development, co-founded by Dr. Maksim Plikus and William Rassman. Users discuss undisclosed product candidates and application methods.

community 1 year of treatment with Fin, Min, keto (M24)

in Progress Pictures 5 upvotes 4 months ago

A user has been treating hair loss for a year with Finasteride, oral Minoxidil, microneedling, and ketoconazole shampoo, recently adding Dutasteride. They are unsure about the effectiveness and seek advice on whether to continue or switch fully to Dutasteride.

community Does SCUBE3 have the potential to regrow a juvenile hairline?

in Treatment 2 upvotes 1 year ago

The conversation is about the potential of SCUBE3 to regrow a juvenile hairline. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community Help me understand hair/shed cycles. After 6 months of Fin, losing ground again

in Finasteride/Dutasteride 14 upvotes 2 years ago

After 6 months of using finasteride, minoxidil, RU58841, and microneedling, the user experienced hair regrowth but then noticed a significant shed, returning to the initial state of hair loss. Another user responded that shedding every 6-8 months is normal when using finasteride and advised to continue the treatment for thicker hair regrowth.

community First patient dosed with Pyrilutamide (Kintor) Phase III

in Research/Science 200 upvotes 2 years ago

First patient dosed with Pyrilutamide (Kintor) Phase III for hair loss treatment. Pyrilutamide differs from approved treatments as it competes with DHT to bind hair follicles, potentially reducing side effects.

community It's probably RU58841, which is weak in adenosine.

in Treatment 14 upvotes 5 months ago

The conversation is about using adenosine, finasteride, and minoxidil for hair loss treatment. The user ordered a 0.75% adenosine solution and is currently using finasteride 1mg and minoxidil 5%.

community 3 months progress fin/min + dermarolling (before and after pictures with dates included)

in Progress Pictures 23 upvotes 6 months ago

User shared 3-month progress using finasteride, 5% topical minoxidil twice daily, and weekly dermarolling. They showed before and after pictures, noting significant improvement.

community Adding an emollient to Minoxidil to avoid the dryness

in Research/Science 2 upvotes 3 weeks ago

Minoxidil causes dryness, and adding an emollient might help. The foam version is suggested to reduce dryness.

community Injured temple with derma rolling

in Microneedling 2 upvotes 3 months ago

OP injured their temple using derma rolling and tretinoin, causing peeling and potential hair follicle damage. Users suggest the injury might be permanent, possibly resulting in scar tissue where hair won't grow.

community Has anyone else noticed their hair getting super dry while using dutasteride?

in Finasteride/Dutasteride 7 upvotes 6 months ago

A user experienced dry, brittle hair after starting dutasteride and considered switching back to finasteride. Another user advised that the dryness is temporary and shared positive results with dutasteride and oral minoxidil after several months.

community Expectations control for SCUBE3

in Research/Science 21 upvotes 9 months ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Post Finasteride Syndrome, A dangerous lie.

in Chat 142 upvotes 10 months ago

A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.

community New potential hair loss treatment (news release)

in Treatment 186 upvotes 4 years ago

New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

community Red Light Therapy: my experience

in Research/Science 15 upvotes 5 months ago

A user shared their positive experience with the Omnilux Red Light mask for skin and potential hair benefits, while also using Minoxidil, Dutasteride, and RU58841. They recommend the mask for those interested in skincare and red light therapy, despite being unsure of its effectiveness for hair growth.

community Crown growth update ~ 7 months Fin and topical Min

in Progress Pictures 118 upvotes 6 months ago

User shared progress on hair growth after 7 months of using Finasteride and Minoxidil. They hope for thicker hair on the crown.

community progression 1 month male 22 balding

in Progress Pictures 8 upvotes 1 year ago

A 22-year-old male using finasteride, minoxidil, and derma stamping for one month reports progress in hair loss treatment. He also uses vitamin D, omega-3, beta carotene, tongkat ali, and ag powder, and maintains an active lifestyle.

community Dry hair vs wet hair, is minox, microneedling and ketoconazole enough?

in Treatment 110 upvotes 1 year ago

The conclusion of the conversation is that using minoxidil, finasteride, and ketoconazole may not be enough to address hair loss caused by DHT. Some users recommend starting finasteride to prevent further hair loss, while others express concerns about potential side effects.

community I‘ll be the guinea pig just help me with the maths

in Research/Science 4 upvotes 1 year ago

A user discusses using a mix of 10% CBD oil and emu oil for hair regrowth, seeking help to apply 3-4 mg daily. They mention needing 0.5-1ml to cover their buzzed scalp.

community Anyone use Verteporfin with their hair transplant yet?

in Transplants 12 upvotes 3 years ago

User discusses using Verteporfin for hair regrowth after hair transplant. Replies mention successful follicle regrowth in studies and mice, questioning if it can be replicated in humans.

community Take multivitamins if you have sexual side effects! it's amazing

in Product 20 upvotes 3 years ago

A user shared that taking multivitamins, specifically Myprotein "Alpha Man," improved their sexual energy while on finasteride. They believe the benefits come from Zinc and Vitamin B6/12.

community What's the consensus about Minoxidil and skin aging/effects?

in Minoxidil 7 upvotes 4 years ago

The conversation discusses concerns that Minoxidil may cause skin aging, like collagen depletion and puffier faces. Some users suggest that a good skincare routine or collagen supplements might prevent these effects.

community It really works! (2 months progress)

in Is this regrowth? 224 upvotes 3 weeks ago

A user shared their positive two-month progress using a hair loss treatment plan including finasteride, minoxidil, dermarolling, ketoconazole shampoo, and vitamins. They noted significant hair regrowth and thickness improvement, attributing success to the combination of treatments.

community The day they make a pill that only targets DHT production in the scalp

in Finasteride/Dutasteride 29 upvotes 1 month ago

Reducing DHT in the scalp is ideal for hair retention, with topical finasteride and dutasteride being common treatments. Some users report side effects like reduced libido, while others experiment with higher doses for regrowth.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Why you shouldn’t trust “progress” pictures.

in Chat 388 upvotes 2 months ago

Hair loss progress pictures can be misleading due to differences in lighting, hair length, and wetness, making it hard to accurately assess changes. Treatments mentioned include minoxidil and finasteride, with some users expressing skepticism about their effectiveness.

community 3 Month Progress Pictures - Start -> Current

in Progress Pictures 139 upvotes 3 months ago

A user shared their 3-month hair loss treatment progress using 5% topical Minoxidil, Finasteride tablets, dermastamping, and ketoconazole shampoo. They reported significant improvement, advised consistency, and addressed questions about side effects and application methods.