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GlossaryInterfollicular Epidermis

outer skin layer between hair follicles

The interfollicular epidermis is the part of the skin's outer layer that exists between hair follicles. It plays a crucial role in protecting the body from environmental damage, preventing water loss, and serving as a barrier against pathogens. This area is composed of multiple layers of cells, including keratinocytes, which are responsible for producing keratin, a protein that strengthens the skin.

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community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 1 year ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Roughly 1.5 years progress. Dut, Fin, Minox, RU.

in Progress Pictures 795 upvotes 2 years ago

A user's progress with treatments for hair loss, including Dutasteride, Finasteride, Minoxidil, and RU. Other members of the conversation provided tips such as using Microneedling and Tretinoin to increase regrowth and wounding areas of the scalp that are thinning in order to fill them in.

community NW6 - 12 months progress - Dut/Oral Min/2% Keto Shampoo

in Progress Pictures 141 upvotes 5 months ago

User shared 12-month hair loss progress using oral minoxidil, oral dutasteride, and 2% ketoconazole shampoo. They detailed their medication regimen and dosages.

community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

in Female 42 upvotes 3 years ago

User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

community He used Dutasteride for 20 YEARS: TL;DR Slight gains and largely stable for 20 years.

in Treatment 25 upvotes 9 months ago

John has experienced slight hair gains and stability over 20 years using Dutasteride, which is more effective than Finasteride in reducing scalp DHT and maintaining hair. Dutasteride at 0.5mg daily has a similar side effect profile to Finasteride, but at higher doses, it may increase the risk of sexual side effects.

community Why I really believe the tension theory is the cause of MPB

in Research/Science 70 upvotes 3 years ago

The conversation discusses the tension theory as a cause of male pattern baldness (MPB), suggesting that scalp tension and reduced subcutaneous fat layer contribute to hair loss. Treatments mentioned include Minoxidil, finasteride, microneedling, scalp massages, and Botox.

community Bryan Johnson just dropped his anti hair loss formula

in Treatment 339 upvotes 10 months ago

Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

community 21M, 80 days progress is insane

in Progress Pictures 290 upvotes 1 year ago

The post discusses a 21-year-old male's successful hair regrowth after 80 days using 0.5mg of oral finasteride daily, 1ml of Minoxidil twice a day, and a 0.25mm derma roller twice a week. The comments encourage him to maintain the regimen to prevent hair loss again.

community Just over 2 months on min/fin/derma/niz + vitamins

in Progress Pictures 456 upvotes 2 years ago

A user's experience with hair loss treatments including minoxidil, finasteride, derma roller, nizoral shampoo and various vitamins; the user reported great progress over two months.

community The theory that explains everything. The malloclusion theory has been proven.

in Research/Science 27 upvotes 1 year ago

Brian Dye's theory links skeletal malocclusion type II to hair loss, suggesting it's a blood flow issue. Treatments mentioned include minoxidil, finasteride, and anti-inflammatory drugs like benaxoprofen.

community In my opinion baldness is more prevalent now and it's being ignored..

in Chat 236 upvotes 1 year ago

The conversation is about the prevalence of baldness among young men and the potential factors contributing to it. Specific treatments mentioned include minoxidil and finasteride.

community Oral Minoxidil Users In A Nutshell

in Satire 1212 upvotes 2 years ago

This conversation is about hair loss treatments, specifically oral minoxidil and finasteride. Users discussed the potential side effects of using these drugs, as well as their experiences with them.

community Minoxidil is connecting the hair on the inner part of my arms

in Satire 1 year ago

This conversation is about a user who has been using Minoxidil for nine months and just noticed hair growing on the inner part of their arms. Responses to this post suggest that they should continue using it, with an increase in frequency from 5% twice a day, as well as trying finasteride if needed.

community How many Dut pills does it take to have Franz Kafka's hairline?

in Satire 48 upvotes 1 year ago

The post and conversation discuss hair loss treatments and the uncertainty of their results. Some users suggest that artificial hair systems might be the best solution, while others express preference for maintaining a mature hairline rather than aiming for a youthful one.

community DHT levels after 4 weeks of Fina and 8 weeks of Fina + 4 weeks of Duta

in Update 35 upvotes 5 years ago

The user reported early stage diffuse hair thinning and increased DHT levels after 4 weeks on Finasteride and 8 weeks on Finasteride plus 4 weeks on Dutasteride, despite the medications being authentic and stored properly. They are considering increasing their Dutasteride dosage due to the lack of side effects and are unsure if the treatment is helping their hair.

community Veradermics VDPHL01: why isn’t anyone talking about it?

in Treatment 31 upvotes 1 week ago

Veradermics' new hair loss treatment, VDPHL01, is likely a modified release oral minoxidil, which has received $75 million in funding for clinical trials. Despite skepticism about investing in a known treatment, some believe it could offer improved efficacy and reduced side effects.

community 9 months on Finasteride 1,25mg + HRT

in Transgender 17 upvotes 7 months ago

The conversation is about the results of using hormone replacement therapy (HRT) with estrogen and finasteride for hair loss, and switching from finasteride to bicalutamide as an anti-androgen treatment. The user shared before and after photos to discuss the effectiveness of these treatments.

community Vitamin D - I was taking vitamin D last 6 month, my hair is back(4000UI daily)

in Progress Pictures 566 upvotes 1 year ago

User took vitamin D for 6 months and experienced hair regrowth. Others suggest comparing hair at the same length and lighting for accurate results.

community Group Buy for MR antagonist finerenone

in Product 11 upvotes 1 year ago

User discusses group buy for finerenone, a third-gen mineralocorticoid antagonist for hair loss treatment. Finerenone inhibits TGFb, NOX, and ROS, and improves renal and cardiac function; topical dose should be no more than 10mg per day.

community Dutasteride Mesotherapy, has anyone tried this?

in Treatment 6 upvotes 3 years ago

The conversation is about trying dutasteride mesotherapy for hair loss, with concerns about its effectiveness and potential side effects compared to finasteride. The user is considering this treatment available in California.

community Shouldn’t it be impossible for dutasteride to make hair loss worse?

in Finasteride/Dutasteride 39 upvotes 4 months ago

Dutasteride is unlikely to worsen hair loss; shedding is often temporary. Other factors like inconsistent use, placebo effect, or additional treatments may influence perceived results.

community 30 Months of Progress (Or How I Stopped Worrying and Learned to Love the Hair)

in Progress Pictures 108 upvotes 7 months ago

A user shared their 30-month hair loss progress using Minoxidil, finasteride, and RU58841. They also discussed hair transplants as an option for future hair loss.

community Grey Market GT20029 and Frequency of Application

in Product 9 upvotes 7 months ago

The conversation is about the potential release of GT20029 on the grey market and concerns about its safety and authenticity. One user advises waiting for the official release by Kintor.

community 1 year of finasteride, minoxidil (capsules) and rosemary oil. (Side note I also… lost weight, had a LOT of therapy for unresolved childhood trauma and started arresting my unhelpful thinking/ useless self hatred/ judging myself and others/ hair loss) 🥹

in Progress Pictures 1013 upvotes 11 months ago

The user shared a one-year progress of treating hair loss with finasteride, minoxidil capsules, and rosemary oil, and also improved mental health by addressing childhood trauma and changing negative thought patterns. Commenters congratulated the user on both hair regrowth and mental health progress, with one asking for advice on overcoming self-hatred and low confidence.

community Does whey protein and creatine aggravate hair loss?

in Research/Science 82 upvotes 1 year ago

The conversation discusses whether whey protein and creatine worsen hair loss. Some users report hair loss with creatine use, while others do not; opinions on whey protein's effects are mixed. Treatments mentioned include PRP, minoxidil, and finasteride.

community Ashton Kutcher talked about on the tonight show how he was quitting dut. Looks like the Norwood reaper has already come to collect.

in Satire 623 upvotes 1 year ago

The conversation is about Ashton Kutcher's hairline and how some people think it looks good for his age, while others criticize it. Some mention that he used to use medication for hair loss but stopped.

community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 1 year ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community Pyrilutamide vs Ru58841 thoughts

in Research/Science 8 upvotes 1 year ago

The user has been using Pyrilutamide (Pyril) for hair loss for a month alongside finasteride/dutasteride since 2021 but hasn't seen results. They are considering switching to RU58841 due to its many success stories, despite being skeptical about the legitimacy and testing of Pyrilutamide.