community Information regarding Follicusan DP?
Follicusan DP is discussed as a potential alternative to Minoxidil without side effects, but information is scarce. It is noted to be of German origin and details on its mechanism are limited.
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30 / 1000+ resultscommunity Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy
A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.
community What is the deal with "longitudinal partial follicular unit transplantation"
Longitudinal partial follicular unit transplantation involves extracting part of the donor follicular unit, allowing the donor area to be overharvested without noticeable hair loss. The conversation questions if this method is practiced in clinics or if it's theoretical, and whether it relates to hair cloning or multiplication.
community What is the deal with "longitudinal partial follicular unit transplantation"
Longitudinal partial follicular unit transplantation involves extracting part of the donor follicular unit, allowing the donor area to maintain hair production and potentially increasing transplant yield. The conversation questions if this method is practiced in clinics or remains theoretical, and whether it relates to hair cloning or multiplication.
community Can single hairs follicules be able to produce two hairs once again with treatment? Never saw a study about that.
The conversation is about whether treatments like finasteride, dutasteride, and minoxidil can make single hair follicles produce multiple hairs again. The user is curious if these medications can thicken hair and prolong the growth phase.
community Any thought on the FSCT (Follicular Stem Cell Therapy) procedure?
FSCT is a non-surgical procedure using stem cells from healthy hair follicles to promote hair growth. It is compared to PRP and is offered by a clinic in India.
community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026
PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.
community Pelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Presented at the American Academy of Dermatology (AAD) Annual Meeting 2026 28th march
Pelage Pharmaceuticals' PP405 aims to treat hair loss by reactivating dormant hair follicle stem cells, showing promising results in early trials. The company plans to present their findings at the American Academy of Dermatology Annual Meeting in 2026.
community Pelage Pharmaceuticals’ PP405 and its Impact on Follicular Regeneration to be Presented at the American Academy of Dermatology (AAD) Annual Meeting 2026
PP405 shows promise in regenerating hair by activating dormant follicles. Other treatments like VDPHL01 and Breezula are also advancing, providing new hope for hair loss solutions.
community Minoxidil Skin Delivery from Nanoemulsion Formulations Containing Eucalyptol or Oleic Acid: Enhanced Diffusivity and Follicular Targeting
Minoxidil can be effectively delivered through nanoemulsions containing eucalyptol or oleic acid, enhancing its diffusivity and targeting hair follicles. This contradicts the advice against mixing minoxidil with oils in topical formulations.
community Do the more newer gen topical retinoids e.g. tazarotene outperform tretinoin in inducing follicular sulfotransferase activity?
Tazarotene may outperform tretinoin for hairline treatment with minoxidil, but lacks evidence. Tretinoin is recommended for the scalp, while tazarotene can be used on the face.
community Napkin math: are we using 100x more topical finasteride than necessary?
Topical finasteride concentrations are likely much higher than necessary for effective follicular DHT suppression, with current standards being 100-1000 times above the theoretical minimum. Lower concentrations (0.001-0.0025%) might still work locally while minimizing systemic exposure.
community Does Retinol by itself affect hair regrowth?
Retinol alone may not significantly affect hair regrowth and can cause hair shedding in some users. Tretinoin, a retinoid, might enhance the absorption of other treatments and increase follicular sulfotransferase expression.
community 1.25mg oral minoxidil every day, 0.5mg dutasteride every other day - 4 months progress
OP is using 1.25mg oral minoxidil daily and 0.5mg dutasteride every other day for hair loss, with noticeable progress after 4 months and no significant side effects. OP experienced chest pain with a higher dose of minoxidil previously but has had no issues with the current regimen.
community PP405 Never Worked: the follicles were already activated at baseline
PP405 was ineffective for hair growth as some follicles were already active before treatment, raising doubts about its efficacy. Users discussed other hair loss treatments like Minoxidil, finasteride, and RU58841, expressing skepticism and hope for future solutions.
community Is RU58841 worth it? Has anybody seen success on it?
RU58841 is used by some for hair loss, with mixed results; one user reported success with no side effects, while another experienced lung and heart issues. RU58841 is often sourced from third-party vendors and used alongside treatments like dutasteride and minoxidil.
community Vellus terminal microscope study
The conversation discusses hair regrowth progress using Minoxidil, finasteride, and RU58841. It highlights the transformation of vellus hairs into terminal hairs in a Norwood 6 frontal area.
community Diamond Hair Clinic in Istanbul - Doctor Mehmet Demircioglu - 20/04/25
A user shared their positive experience with a hair transplant at Diamond Hair Clinic in Istanbul, performed by Dr. Mehmet Demircioglu, using the Sapphire FUE technique with 4500 grafts. They previously used minoxidil and finasteride, which helped slightly, and plan a follow-up surgery for further improvements.
community Will PP405 work if even dutasteride / fin failed to halt hair loss?
The conversation discusses the ineffectiveness of dutasteride in halting hair loss for the user and explores the potential of PP405, which works through a different mechanism. Suggestions include considering a biopsy to determine the cause of hair loss and exploring other treatments like RU58841.
community People who don’t microneedle, why?
Microneedling is often combined with minoxidil for hair growth, but concerns about scalp damage, pain, and effectiveness deter some users. Alternatives like finasteride, dutasteride, tretinoin, and laser treatments are preferred by others.
community a new supplement just released
A dermatologist recommended a new supplement containing annurca apple, which reportedly doubles hair density and increases keratin after 60 days, to be used with finasteride. Some users are skeptical, considering it potentially ineffective or a marketing ploy, while others are open to trying it if it proves effective and affordable.
community Non responsive diffuse thinning
The user has been experiencing diffuse hair thinning despite using finasteride, minoxidil, dermarolling, clobetasol cream, and PRP sessions. They seek advice on additional treatments and are advised to check vitamin D, iron, and thyroid levels.
community anti-androgens help with chronic seborric dermatitis ?! and hence diffuse thinning
An 18-year-old experiencing hair loss and seborrheic dermatitis has tried finasteride, dutasteride, and various shampoos without success. They are considering anti-androgens like RU58841 and KX-826 for oil control and dandruff reduction.
community 2 months progress , dutasteride 0.5mg + minoxidil 5mg and more…
The conversation is about hair regrowth progress using dutasteride and minoxidil. Users discuss their experiences, progress, and side effects with these treatments.
community 28M 5MG MIN 0.5MG DUT DAILY - DO. NOT. FEAR. THE. SHED
A user shared their positive experience with hair regrowth using daily minoxidil and dutasteride, despite initial shedding. They noticed significant progress around month 4 and encouraged others to be patient with the process.
community Am I crazy or does it look like I'm getting a response with dutasteride after a couple of months.
The user is experiencing hair regrowth after using a regimen of 2.5mg minoxidil, 0.5mg dutasteride, 1mg biotin daily, micro-needling weekly, and nizoral every three days. Other users confirm seeing signs of regrowth and encourage the user to remain optimistic.
community Why I Take 5mg Minoxidil at Night Instead of Splitting 2.5mg
Taking 5mg oral minoxidil at night instead of splitting 2.5mg doses, with the rationale that a single larger dose may provide a stronger activation for hair follicles and reduce peak-related side effects. Some users report sleep issues with nighttime dosing, while others find it beneficial; opinions on effectiveness and side effects vary.
community Body hair growth on finasteride
Finasteride can increase body and facial hair growth due to increased testosterone, despite its intended use to reduce hair loss on the scalp. Some users consider trying topical finasteride for less systemic impact, while others report mixed results and side effects.
community Sooo whats the consensus about pp405 now?
PP405 may help with hair regrowth, especially when combined with minoxidil and finasteride, but its long-term effectiveness is unclear. Phase 3 trials are expected to begin soon, with results in a few years.
community Found a slide summary for PP405
PP405 shows promise in stimulating new terminal hair growth by activating dormant follicles, with no systemic adverse effects observed in a short-term trial. However, long-term efficacy remains unproven, and further trials are needed to confirm its potential as a hair loss treatment.