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GlossaryEstradiol Valerate

synthetic estrogen used in hormone replacement therapy

Estradiol Valerate (E2V) is a synthetic form of the hormone estradiol, which is a type of estrogen. It is commonly used in hormone replacement therapy (HRT) for menopausal symptoms and in transgender hormone therapy. The valerate ester allows for a slower release and longer duration of action when administered, typically via injection.

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community FtM: "Aggressive Regemin - Recovery From Norwood-6.5" Minoxodil/Estradiol valerate/Spironolactone. (What will happen in the worst case if CIS male go this way for a year?)

in Progress Pictures 54 upvotes 3 years ago

User "Ant1pal" shares progress pictures of hair regrowth using Minoxidil, Estradiol valerate, and Spironolactone. Users discuss potential side effects and the possibility of localizing estrogen to hair follicles for better treatment.

community Found the solution tressbros - 1.5 years 2.5mg oral minox, 5mg finasteride, 8mg estradiol valerate (weekly)

in Transgender 591 upvotes 10 months ago

The conversation discusses a transgender individual's successful hair loss treatment over 1.5 years using 2.5mg oral minoxidil, 5mg finasteride, and 8mg weekly injectable estradiol valerate. Some users debate the appropriateness of this approach within the group's goals, while others support the individualized treatment and its additional benefits for transgender individuals.

community Well… I Did It. Estrogen Saved My Hairline

in Transgender 720 upvotes 2 months ago

OP transitioned and used Spironolactone, Estradiol Valerate, Minoxidil, and dermarolling, resulting in significant hair regrowth. They advise this method may not be suitable for cis men.

community How effective is spironolactone?

in Transgender 6 upvotes 2 years ago

A 21-year-old MTF individual is experiencing rapid hair thinning and is currently on estradiol valerate. They are inquiring about the effectiveness of spironolactone for hair loss, despite being aware of its serious side effects.

community progress pics (HRT, fin, min, microneedling) (35, trans non-binary)

in Transgender 10 upvotes 1 week ago

A non-binary transfeminine person experienced significant hair regrowth after starting finasteride, minoxidil, microneedling, and hormone replacement therapy with estradiol. They encourage trans individuals concerned about hair loss to consider estrogen as it has greatly improved their hair condition.

community What’s the highest minox % you home brewed ?

in Minoxidil 2 upvotes 4 months ago

A user discusses their experience with dissolving high concentrations of minoxidil in various ethanol/PG ratios and mentions difficulties with combining it with RU58841. They note that a 5% minoxidil solution remains stable, while higher concentrations tend to precipitate.

community Recovering density loss from TRT with topical dutasteride, minox, keto and 3.5% fluridil

in Progress Pictures 6 upvotes 3 years ago

Hair density improved using topical dutasteride, minox, keto, and 3.5% fluridil for 6 months. Better results when hair is dry, but still unsatisfied when wet.

community Estradiol blood test on fin. Doctor dont want to give me the test.

in Finasteride/Dutasteride 10 upvotes 1 year ago

The user has been taking 0.5 finasteride for 10 months and wants to repeat blood tests, including estradiol. However, their doctor is reluctant to test estradiol, arguing it's typically low in men, and the user is considering seeking a second opinion.

community Does anyone manage to keep the estradiol under control while on fin ? I'm talking in the normal range

in Chat 3 upvotes 4 months ago

Managing estradiol levels while using finasteride. Treatments discussed include Minoxidil, finasteride, and RU58841.

community Finasteride has increased my Estradiol (estrogen) levels by 51% percentage

in Finasteride/Dutasteride 12 upvotes 1 month ago

Finasteride increased the user's estrogen levels by 51%, causing concerns about gynecomastia and sleep issues. Despite potential side effects, the user prefers continuing finasteride to prevent hair loss, considering it essential for self-esteem.

community 2 months of difference with estradiol and spiro (4 months total w/ estradiol & spiro; 4 years of minoxidil and finasteride) (you should not take estradiol or spiro if you look manly and want to continue looking manly)

in Transgender 115 upvotes 1 month ago

Hair regrowth using estradiol, spironolactone, minoxidil, and finasteride, showing significant improvement over four years. HRT is not advised for cis men solely for hair loss due to feminizing effects.

community Everyone seems to be looking for an antiandrogen as an add on. But what about Estradiol & its derivatives ( excluding the low concentraion alfatradiool ) being used. Anyone has an experience with this ? Anything that won't cause feminization in the process ?

in Chat 6 upvotes 2 months ago

The conversation discusses using estradiol and its derivatives for hair loss without causing feminization. Users mention alternatives like alfatradiol, topical 17b-Estradiol, and DIM (Diindolylmethane).

community Has anyone used topical estrogen or estradiol for hair loss and how effective was it?

in Treatment 1 upvotes 2 months ago

Topical estrogen or estradiol for hair loss is being discussed for its effectiveness compared to finasteride. Users are sharing their experiences and opinions on its potential benefits.

community Dim: high estradiol levels what to do

in Chat 8 upvotes 4 months ago

A user is experiencing facial bloating from low-dose topical finasteride due to high estradiol levels and is seeking advice on using DIM to manage this issue, including dosage and brand recommendations.

community Began MTF HRT (estradiol/spironolactone) at 39. The images are about 5 months apart. I haven't started minoxidil yet as I'm waiting to see how far I can get with suppressing T alone. I'm guarded, but hopeful I won't be needing wigs eternally.

in Transgender 7 upvotes 4 months ago

A transgender individual began MTF HRT with estradiol and spironolactone at 39 and is monitoring hair regrowth before starting minoxidil. They are hopeful about not needing wigs permanently.

community How to get rid of Estradiol Problems

in Finasteride/Dutasteride 6 upvotes 7 months ago

The conversation discusses managing estradiol problems during finasteride treatment. Suggestions include stopping finasteride every 3 months for 2-3 weeks or reducing the dosage.

community 1 month of finasteride sky high estradiol

in Update 7 upvotes 7 months ago

The user reported high estradiol levels after one month of using finasteride for hair loss. They discussed potential side effects and adjustments to their treatment plan.

community Finasteride increase in Estradiol?

in Update 17 upvotes 9 months ago

A user experienced increased estradiol, nipple tenderness, and ED after taking finasteride. They are considering dose reduction to mitigate these effects.

community Finasteride with high estradiol levels

in Finasteride/Dutasteride 6 upvotes 10 months ago

A 22-year-old with high estradiol levels is considering starting finasteride for hair loss. They have an upcoming endocrinologist appointment to discuss whether they should proceed with the treatment.

community 1 Year Estradiol HRT, Oral Finasteride, Bicalutamide, Cyproterone. (20MTF)

in Transgender 4 upvotes 1 year ago

The conversation discusses a 20-year-old transgender female's one-year experience with hair loss treatments, including Estradiol HRT, oral Finasteride, Bicalutamide, and Cyproterone. Specific treatments used for hair loss are oral Finasteride and potentially Estradiol as part of hormone replacement therapy.

community Anyone here who’s using Alfatradiol (17a-Estradiol) in consistency with some results?

in Treatment 6 upvotes 3 years ago

User discusses Alfatradiol (17a-Estradiol) as a potential hair loss treatment with mixed results. Concerns include low dosage, receptor theory, and possible increased aromatase activity on scalp.

community Gained weight on fin but Estradiol is in normal range?

in Finasteride/Dutasteride 1 upvotes 3 months ago

A user gained 10-12 kg after starting finasteride but found their estrogen levels to be within the normal range. They are concerned about potential gynecomastia but are reassured by their lab results.

community Anyone who used topical bicalutamide/estradiol/cyproterone acetate /spironolacton? (Need advice)

in Treatment 5 upvotes 4 months ago

A user is seeking advice on the efficacy and side effects of homemade topical solutions for hair loss, specifically bicalutamide, estradiol, cyproterone acetate, and spironolactone, as they cannot access RU58841 or pyrilutamide.

community for those who had high levels of testo and estradiol after start fin/dut: did it comeback to baseline or normal levels?

in Finasteride/Dutasteride 8 upvotes 5 months ago

A user experienced increased testosterone and estradiol levels after starting finasteride/dutasteride and is asking if these levels will return to normal over time. The conversation focuses on whether these changes are temporary.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 5 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Anyone knows a legitimate online source/distributer of 17α-estradiol (Alfatradiol) powder?

in Treatment 1 upvotes 1 month ago

The conversation is about finding a legitimate online source for 17α-estradiol (Alfatradiol) powder to make a 0.1% solution for hair loss treatment. A user suggests Anagenica as a source.

community Pre-Fin Blood Test, Are my Estradiol Levels Too High For Finasteride?

in Finasteride/Dutasteride 1 upvotes 1 month ago

The user is considering starting finasteride for hair loss but is concerned about potential side effects due to their estradiol levels being near the upper limit. They have consulted a doctor who confirmed their levels are okay to start the treatment.

community 10 Months of Nuclear Stack [Dut, Min, Keto + Estradiol & Spironolactone (MtF HRT)] -- Does it need more time or does it need a transplant?

in Progress Pictures 6 upvotes 2 months ago

The post discusses using a combination of Dutasteride, Minoxidil, Ketoconazole, Estradiol, and Spironolactone for hair regrowth. Users suggest it needs more time and possibly a transplant, with some sharing personal experiences and side effects of similar treatments.

community HRT is literal black magic. Fin 1 mg/day @ 4 years, min 2x/day @ 3 years, Estradiol 4mg/day @ 3.5 months, and Spironolactone 100mg/day @ 3.5 months (estra & spiro are medicines you should likely not take if you are a cis man)

in Progress Pictures 118 upvotes 2 months ago

User shared progress on hair regrowth using Fin 1 mg/day for 4 years, Min 2x/day for 3 years, Estradiol 4mg/day, and Spironolactone 100mg/day for 3.5 months. They noted significant hairline recovery and advised against HRT for cis men due to feminizing effects.

community 4 years; fin 1mg/day @ 4 years; minox twice daily @ 3 years; estradiol 5mg/day @ 3 months; spiro 100 mg /day @ 3 months (Wet hair because it's easy to hide issues with dry hair)

in Progress Pictures 198 upvotes 3 months ago

The user shared their 4-year hair regrowth progress using finasteride, minoxidil, estradiol, and spironolactone. They noted significant regrowth by the second year and additional benefits from estradiol and spironolactone.