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GlossaryEnhancer of Zeste Homolog 2

gene encoding an enzyme that represses gene expression via methylation

Enhancer of Zeste Homolog 2 (EZH2) is a gene that encodes an enzyme involved in modifying chromatin, which is the complex of DNA and proteins in the cell nucleus. This enzyme adds methyl groups to histone proteins, leading to the repression of gene expression. EZH2 is important in regulating cell division and differentiation, and its dysregulation is often associated with various cancers.

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community Why Is Only Tressless Talking About Verteporfin? Healing Wounds With Zero Scarring Has Gargantuan Implications For All of Medicine. So What Gives?

in Research/Science 19 upvotes 1 year ago

The potential of verteporfin to heal wounds without scarring; however, despite its promising preclinical trials and coverage from a major media outlet, there is still no official clinical trial result and the drug has only garnered attention from hair loss communities.

community Can use olive oil instead of PG (propylene glycol) or glycerin in topical finasteride preparation?

in Finasteride/Dutasteride 2 upvotes 3 months ago

A user asked if olive oil can replace propylene glycol or glycerin in topical finasteride preparation. Another user advised against it, suggesting MCT oil instead due to olive oil's potential to worsen dandruff and seborrheic dermatitis.

community Castor oil without using penetration enhancer after microneedling?

in Question 9 upvotes 6 years ago

The conversation is about whether castor oil can be effectively used alone after microneedling without a penetration enhancer like DMSO or ethanol. The user believes microneedling-induced wounds might be enough for absorption.

community Oral minoxidil 2.5 mg since end of July 2024 till November 2024

in Is this regrowth? 464 upvotes 2 weeks ago

Oral minoxidil has shown positive results for hair regrowth, but concerns about its side effects, such as heart issues, are noted. Adding a DHT blocker like finasteride is recommended for better and more lasting results.

community Tretinoin aka retinoic acid, the minoxidil enhancer

in Product 8 upvotes 8 months ago

Tretinoin can make minoxidil more effective for hair loss treatment, but some users did not see improved hair density with this combination and had better results with dutasteride.

community How to layer multiple topicals? (tretinoin, topical min, topical fin)

in Treatment 1 month ago

The user plans to use a combination of tretinoin, topical minoxidil, and topical finasteride for hair loss treatment. They seek advice on application order, timing, and tretinoin dosage.

community Using essential oils as well as minoxidil?

in Minoxidil 6 upvotes 6 years ago

The conversation is about using a blend of coconut oil, peppermint oil, and rosemary oil with minoxidil for hair loss, and whether it's safe to apply this blend after microneedling.

community Fin min micro 2 years. Last pic is for proof fin doesn’t ruin your muscle gains

in Finasteride/Dutasteride 484 upvotes 1 year ago

The conclusion of the conversation is that the user, ZadarskiDrake, has been using minoxidil and finasteride for two years to treat hair loss. They apply minoxidil at night and have not experienced negative effects on muscle gains. They also mention using a needle pin for hair treatment.

community Selling a premixed KY19382 solution

in Research/Science 8 upvotes 2 years ago

The conversation discusses the sale of a premixed KY19382 solution for research purposes, highlighting previous unsuccessful group buys and the formulation process. Prices and purchasing options for KY19382 solutions and powder are provided.

community Dermatologist keeps stressing on diet and vitamins - are they that crucial?

in Treatment 2 upvotes 6 months ago

The conversation is about a user experiencing increased hair loss after altering their treatment routine of oral dutasteride and topical minoxidil. The dermatologist emphasized the importance of diet and vitamins, but the user is skeptical given their healthy lifestyle.

community Sublingual Minoxidil - Cure to Hairloss?

in Minoxidil 583 upvotes 1 year ago

The conversation discusses the potential benefits of sublingual minoxidil for hair loss treatment. It suggests that sublingual minoxidil, which bypasses the liver, may have fewer side effects, greater bioavailability, and could be more effective than oral minoxidil.

community Best supplements to take while on fin to avoid sides?

in Finasteride/Dutasteride 25 upvotes 4 years ago

The conversation discusses using zinc and iron supplements to mitigate side effects of finasteride. It also mentions that shedding is a normal part of the process and suggests a healthy diet, exercise, and sleep to support hair health.

community Minoxidil, microneedling and buying tretinoin from Germany

in Minoxidil 1 upvotes 1 month ago

The conversation discusses using minoxidil with microneedling and considering tretinoin to enhance hair growth, especially for those who are weak responders to minoxidil. It also explores the potential of using tazarotene, a stronger retinoid, to boost minoxidil's effectiveness and addresses purchasing tretinoin from Germany.

community What's the deal with Zinc and DHT?

in Chat 47 upvotes 6 months ago

The conversation discusses the conflicting information about Zinc's effect on DHT and its role in hair loss. It mentions that Zinc can act as a 5AR inhibitor at high doses but may increase DHT if taken to correct a deficiency, and highlights the importance of nutritional balance for hair health.

community My Topical Dutasteride results. 14 months later (0.1%)

in Progress Pictures 82 upvotes 3 years ago

User shared their 14-month progress using topical Dutasteride at 0.1% for hair loss, with significant improvement and no side effects. Others discussed concerns about fertility and questioned the authenticity of the results.

community I am a dermatologist with a clinical interest in alopecia. AMA

in Will treatment work for me? 2 years ago

In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

community Creating the Holy Grail Hair Loss Topical

1 upvotes 4 years ago

The conversation is about creating a natural hair loss topical using ingredients like cetirizine, Zinc Sulphate Heptahydrate, Safflower Extract, Ricinoleic Acid, and others. The user is seeking input and collaboration on this topical formula.

community LeBron James has the most mysterious hair

in Progress Pictures 166 upvotes 3 months ago

LeBron James likely uses hair transplants and possibly hair fibers or sprays to maintain his hairline, but his crown remains problematic. Despite his wealth, he hasn't fully resolved his hair loss, leading to speculation about his treatments and choices.

community Sustaining minoxidil dependent hairs?

in Research/Science 9 upvotes 7 months ago

Minoxidil-dependent hairs fall out if minoxidil is stopped. New treatments like GT20029, FOL055, or TDM105795 might help sustain these hairs.

community Oral Biotin and Topical Minoxidil have a synergy effect in increasing hair growth, the study was only done in healthy subjects and it was only 14 days but it does prove that biotin can play a significant role as an adjunct treatment.

in Research/Science 170 upvotes 1 month ago

Oral biotin combined with topical minoxidil may increase hair growth rate, though the study was limited to healthy subjects and did not measure hair density. Some users report personal benefits from biotin, such as faster nail growth and healthier hair, but concerns about acne and study quality were also mentioned.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community Progress o regress? 2 Years only dermaroller (and RU for only 2 month)

in Is this regrowth? 71 upvotes 1 year ago

The conversation discusses hair loss and treatments, with users suggesting the original poster's hair has receded despite using a dermaroller and RU58841 for two months. Many recommend starting finasteride and minoxidil for better results.

community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 73 upvotes 4 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Microneedling with Topical solution of Min, Dut, and Latanoprost

in Treatment 2 upvotes 11 months ago

A user is considering microneedling to enhance absorption of a prescribed topical hair loss treatment containing Minoxidil, Dutasteride, and Latanoprost, while already taking oral Minoxidil and Dutasteride. They seek advice on the effectiveness and safety of combining these treatments, especially due to the cost and their desire to maximize results.

community Sugars ARE important for hair growth | Glycosaminoglycans as Hair Growth Stimulant

in Research/Science 77 upvotes 3 months ago

Glycosaminoglycans are important for hair growth, and combining minoxidil with tretinoin and Biopeptide-CL may enhance hair growth by boosting glycosaminoglycan levels and improving the hair follicle environment. Users discussed the potential effectiveness and future of these treatments.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

in Finasteride/Dutasteride 13 upvotes 1 month ago

Switching from finasteride to dutasteride may be more effective for hair regrowth due to dutasteride's stronger enzyme inhibition, but combining both drugs could enhance results. Some users report better outcomes with dutasteride, while others recommend a gradual transition to prevent potential hair loss.

community Improve my stack (without Minoxidil)

in Product 36 upvotes 11 months ago

The conversation discusses improving a hair loss treatment stack without using Minoxidil. Microneedling is suggested, Alpecin is deemed ineffective, and there are concerns about the safety of Minoxidil compared to finasteride.

community Pre and Post Dermarolling Routine?

in Microneedling 18 upvotes 4 years ago

The conversation is about a hair loss treatment routine involving dermarolling, finasteride, minoxidil, and natural oils. Suggestions include using shorter needles for better absorption of treatments and longer needles less frequently for hair follicle regeneration.

community Iron Overload and Vitamin D Deficiency - Male Hair Loss

in Treatment 19 upvotes 2 years ago

The conversation discusses hair loss treatments, specifically minoxidil, vitamin D supplements, and the potential impact of iron overload. The user experienced hair regrowth with high-dose vitamin D but faced hair thinning again after reducing the dosage, and is now exploring the role of iron overload in hair loss.

community Any young women losing hair that have tried microneedling and oils?

in Microneedling 32 upvotes 4 years ago

A 25-year-old woman is experiencing hair loss and has started microneedling with a 0.5mm roller, applying a mix of essential oils overnight. She questions whether to switch to a 1.5mm roller and the best order for her routine, while a reply suggests using Minoxidil for better results.