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GlossaryDrug Penetration

process of a drug moving into underlying tissues or bloodstream

Drug penetration refers to the process by which a drug moves from the surface of the skin or another barrier into the underlying tissues or bloodstream. This is crucial for topical treatments, such as creams or ointments, to be effective. Factors like the drug's molecular size, formulation, and the condition of the skin can influence how well a drug penetrates.

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community Creating the Holy Grail Hair Loss Topical

1 upvotes 4 years ago

The conversation is about creating a natural hair loss topical using ingredients like cetirizine, Zinc Sulphate Heptahydrate, Safflower Extract, Ricinoleic Acid, and others. The user is seeking input and collaboration on this topical formula.

community Topical Dutasteride 1% - High dosage?

in Finasteride/Dutasteride 6 upvotes 2 years ago

User asks about two topical dutasteride solutions and wonders if 1% concentration is overkill compared to 0.1%. They also consider trying standard topical dutasteride before using Minoxidil.

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 1 year ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community Soundwaves & Electricity Grows Hair? | Peptide Delivery Model.

in Research/Science 2 upvotes 4 months ago

Iontophoresis and sonophoresis can enhance drug delivery into the scalp. Combining these methods may improve the effectiveness of topical treatments like dutasteride and certain peptides.

community Keratin microspheres - breakthrough

in Research/Science 13 upvotes 9 months ago

A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

community How is it possible for someone to be a non responder to ORAL minoxidil?

in Minoxidil 66 upvotes 8 months ago

Some individuals do not respond to oral minoxidil for hair loss, despite it generally working by improving blood flow to hair follicles. Factors like metabolism, drug interactions, and individual variations in the drug's activation may influence its effectiveness.

community All Drugs in Clinical Trials in 2023

in Research/Science 69 upvotes 1 year ago

12 companies having drugs or therapies in clinical trials during 2023, with various molecules and phases of trial; the probability that some may fail; and progress being made in the field.

community Anyone used CB-03-01 (clascoterone), is it worth it, too risky??

in Research/Science 2 upvotes 6 months ago

The user experienced side effects from low-dose topical finasteride and is considering using clascoterone (CB-03-01) despite concerns about its risks and cost. They seek advice on its effectiveness and potential side effects compared to other treatments like alfatradiol and fluridil.

community RU-58841 Experience (15mg daily dissolved in stemoxydine)

in Treatment 13 upvotes 3 years ago

User experienced reduced hair loss with 15mg RU in Serioxyl but had concerning chest pain. Others suggested consulting a doctor or lowering the dose.

community CAUTION: My Experience with RU58841

in Treatment 13 upvotes 1 year ago

The user experienced concerning side effects like throat irritation, shortness of breath, chest pain, and testicle pain after using RU58841 for hair loss, despite also using finasteride and minoxidil. Other users shared mixed experiences, with one advising to stop using RU58841 due to similar side effects, while another reported significant hair loss reduction without side effects.

community Progress o regress? 2 Years only dermaroller (and RU for only 2 month)

in Is this regrowth? 69 upvotes 1 year ago

The conversation discusses hair loss and treatments, with users suggesting the original poster's hair has receded despite using a dermaroller and RU58841 for two months. Many recommend starting finasteride and minoxidil for better results.

community 6 months Fin 1mg, Min 5%. Progress feels sooooo slow. This month I added 2% keto shampoo daily, 0.1% trentinoin daily, and weekly derma rolling. Hoping for much better results over the next 6 months.

in Progress Pictures 2 years ago

A user's progress after taking finasteride and minoxidil for 6 months, as well as adding other treatments such as keto shampoo, trentinoin, and derma rolling. Replies include advice to keep going and the suggestion of considering a hair transplant.

community Homemade Topical Finasteride Formula?

in Treatment 6 upvotes 2 years ago

User wants to make homemade topical finasteride to minimize side effects and asks about using glycerin, stirring time, storage, and alternative solvents. Another user's comment is unclear.

community Hey /r/ Tressless, thought it would be interesting to take a full journey of hair restoration with you! DAY 1825

in Finasteride/Dutasteride 15 upvotes 4 years ago

The efficacy of various hair loss treatments, including Finasteride and Dutasteride, with personal anecdotal evidence about potential side effects. It also includes advice to get a male hormone blood panel done before starting treatment, and lifestyle changes to minimize side effects.

community SAFFLOWER OIL good alternative for Minoxidil?

in Treatment 1 upvotes 4 years ago

Safflower oil is suggested as an alternative to minoxidil for hair growth, with benefits including scalp conditioning and hair strength enhancement. Studies indicate it may also reverse scalp dermatitis, alopecia, and prevent premature grayness.

community Helicobacter's concocted serum v1

7 upvotes 5 years ago

A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 5 months ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

community What About Phytosterol Alternatives - Rice Bran Oil - Natural DHT Blockers

in Research/Science 4 upvotes 7 months ago

The conversation discusses natural DHT blockers like rice bran oil, which may reduce 5α-reductase activity similarly to Minoxidil and Dutasteride. One user argues that finasteride is more reliable and effective than natural alternatives.

community How does it feel to microneedle at 0.3mm?

in Microneedling 17 upvotes 8 months ago

The conversation discusses microneedling for hair loss, with one user trying 0.3mm daily without feeling pain and questioning its effectiveness. Another user suggests that 0.3mm is too shallow and recommends 0.5mm twice a week or 0.75mm once a week for hair growth.

community 3 years of slowww progress. Thoughts?

in Progress Pictures 348 upvotes 10 months ago

The user stopped taking oral finasteride due to depression and now uses a topical finasteride/minoxidil mix with some scalp irritation. They plan to start derma stamping and have seen some improvement in their hair over three years, which others have noticed and encouraged them to continue their efforts.

community Assistance on homemade topical finasteride regimen please?

in Finasteride/Dutasteride 2 upvotes 1 year ago

User has maintained hairline with minoxidil for 8 years but now seeks to add topical finasteride due to increased hair loss. They request advice on making a homemade finasteride solution, including ingredient recommendations and optimal percentages for ethanol and glycerin.

community A Nuanced Look at Microdosing Topical Finasteride

in Finasteride/Dutasteride 86 upvotes 1 year ago

The conversation discusses using a low dose of topical finasteride to achieve hair benefits with minimal systemic exposure. Users share experiences and opinions on dosing, systemic buildup, and side effects of both topical and oral finasteride.

community to all people who cannot tolerate anti androgens (loe dose topical fin, pyrilutamide, CB) i am getting desperate, looking for a solution

in Research/Science 13 upvotes 1 year ago

The user tried Minoxidil without success, and Finasteride worked but caused sexual side effects even at a very low dose. They are seeking alternative treatments for hair loss as they cannot tolerate anti-androgens and are also in therapy for mental health.

community 4,5 months results: Fin, Minoxidil, microneedling. Details in comment

in Progress Pictures 448 upvotes 2 years ago

User shared 4.5-month hair loss treatment results using Fin, Minoxidil, and microneedling. Others discussed postponing hair transplant and adjusting microneedling depth.

community My personal experience/observations fighting AGA seriously for 5 years

in Treatment 43 upvotes 2 weeks ago

Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.

community Low-Dose Oral Minoxidil Does Not Significantly Affect BP

in Minoxidil 178 upvotes 1 month ago

Low-dose oral minoxidil is used for hair loss and does not significantly affect blood pressure but may increase heart rate and cause hypotensive symptoms. Some users experience side effects like palpitations and shortness of breath, while others find it effective; topical minoxidil with tretinoin is also considered.

community Why isnt topical fin talked about more?

in Chat 44 upvotes 1 month ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community Bryan (the guy who reversed aging) shares treatment that reversed his hair loss

in Treatment 1079 upvotes 1 month ago

A person improved hair loss from Norwood 3 to Norwood 2 using a topical formula with minoxidil, dutasteride, and tretinoin, plus oral minoxidil and red light therapy. There is skepticism about the treatment's effectiveness and concerns about misleading comparison photos.

community My microneedling journey (no min, fin, etc)

in Microneedling 208 upvotes 2 months ago

The user experienced positive hair growth results using microneedling with rosemary and mint oil, without Minoxidil, Finasteride, or RU58841. They switched from a dermaroller to a microneedling pen and targeted different scalp areas weekly.

community No regrowth after oral min, topical fin, min, and tret: Aggressive diffuse/hairline recession in 2 years

in Is this regrowth? 116 upvotes 3 months ago

A user experienced no hair regrowth after using oral minoxidil, topical finasteride, minoxidil, and tretinoin, and reported side effects from oral finasteride. They are considering switching to dutasteride or using hair fibers for better results.