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GlossaryDehydroepiandrosterone Sulfate (DHEA-S)

hormone precursor influencing sex hormones and hair growth

Dehydroepiandrosterone Sulfate (DHEA-S) is a hormone produced primarily by the adrenal glands, and it serves as a precursor to male and female sex hormones, including testosterone and estrogen. It plays a role in the development of secondary sexual characteristics and can influence hair growth and skin health. Elevated or decreased levels of DHEA-S can be indicative of various health conditions, such as adrenal disorders or polycystic ovary syndrome (PCOS).

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community Possible explanation of why Dutasteride seems to be worse for some people’s hair.

in Treatment 47 upvotes 1 year ago

The conclusion of the conversation is that some individuals may experience a condition called reactionary hypergonadism when taking dutasteride for hair loss. This condition can lead to an increase in testosterone levels, which may worsen hair loss instead of improving it.

community Female AGA - Low Cortisol/Low DHEA

in Female 7 upvotes 1 year ago

Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.

community Blood test 3 days after finasteride. Is it ok?

in Finasteride/Dutasteride 3 upvotes 6 months ago

A user asked if taking a blood test 3 days after starting finasteride would affect the results for Estradiol, FSH, SHBG, Progesterone, and DHEA-S. The conversation is about the timing of blood tests after beginning finasteride treatment.

community My Experience and a Discourse on "DUPA"

in Treatment 9 upvotes 6 months ago

The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

community AA and Hirsutism but T levels are normal

in Female 8 upvotes 3 years ago

27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.

community I think I’m on to something

24 upvotes 5 years ago

The user shared their personal experience with hair loss, hormone imbalances, and treatments including testosterone boosters, natural estrogen blockers, and DHEA. They suggest that low-dose finasteride and natural hormone therapy could reduce hair loss with fewer side effects.

community Zix + Topical Fin : Blood Test Before/After, AMA and suggestions

in Treatment 47 upvotes 4 years ago

A user's plan to use Zix and topical finasteride (5AR inhibitors) for hair loss, followed by blood testing before/after. The user has suggested creating a fund to cover part of the cost of their blood tests. Replies to their post discuss the effectiveness of the treatments.

community Am I safe to take finasteride with these blood results?

in Finasteride/Dutasteride 1 upvotes 3 months ago

A user is concerned about taking 1mg/day of finasteride due to potential gynecomastia, given their blood results. They seek advice on how their hormone levels might be affected by blocking DHT.

community Is it possible that dutasteride won’t make you depressedd if finasteride did?

in Chat 16 upvotes 8 months ago

The conversation discusses whether dutasteride might cause less depression than finasteride for hair loss treatment, with some users suggesting it could due to different mechanisms of action or molecular size, while others express skepticism or share personal experiences with these medications.

community Pre Finasteride Treatment, is testing for free DHT necessary?

in Finasteride/Dutasteride 5 upvotes 1 year ago

The conversation is about whether testing for free DHT is necessary before starting Finasteride for hair loss, despite having other hormone tests available. One person suggests that genetic response to DHT is more important than DHT levels and advises starting Finasteride without the free DHT test.

community This is lagunaboy and I have fully recovered from PFS

in Finasteride/Dutasteride 5 upvotes 2 years ago

The user recovered from Post-Finasteride Syndrome (PFS) using a specific hormone protocol after trying finasteride and dutasteride. They now help others with PFS by reviewing blood work and offering personalized advice.

community The Hormonal Profile of MPB/AGA

in Research/Science 9 upvotes 3 years ago

Men with early male pattern baldness (MPB) may have hormonal abnormalities similar to those in women with PCOS. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community Just swallowed my first 1mg pill of finasteride! Let the journey begin...

in Finasteride/Dutasteride 29 upvotes 4 years ago

A user started taking 1mg finasteride for hair loss and plans to follow a thrice-weekly dosing schedule recommended by two doctors. They previously used saw palmetto without issues and are hopeful finasteride won't cause sexual side effects.

community Is it too late to regrow my hair?

in Question 14 upvotes 5 years ago

A 29 year old female with hair loss issues that have been linked to PCOS; the user has started taking Spironolactone and iron supplements in hopes of regrowing their hair, but is wondering if it's too late.

community Lifestyle choices and your hair....

6 upvotes 5 years ago

A person noticed increased hair thinning after changing their workout routine from cycling to weightlifting, which also coincided with a rise in testosterone levels. They are considering stopping intense workouts, switching to yoga, cutting out caffeine, and re-evaluating after a few months to see if it improves their hair condition.

community DUPA VS. FAPD, which is more treatable? Which is worse?

in Research/Science 8 upvotes 3 weeks ago

DUPA is considered more treatable than FAPD, as FAPD involves scarring that prevents hair regrowth. The user has started treatment with oral dutasteride and minoxidil, hoping for better results than previous treatments.

community Female, 27 years old, shedding/ balding despite being on what is considered to be a effective treatment plan for AGA. Considering Dut (oral) . Please help.

in Finasteride/Dutasteride 27 upvotes 2 months ago

A 27-year-old woman with androgenic alopecia is losing hair despite using oral minoxidil and spironolactone, and is considering dutasteride. She is exploring causes like stress and medication side effects, planning tests, and considering treatment changes.

community How does hair loss and recovery work?

in Chat 12 upvotes 3 months ago

Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

community Has anyone had experience with 1mg + of dut?

in Finasteride/Dutasteride 9 upvotes 6 months ago

A user is asking about increasing their dutasteride dosage from 0.5mg to up to 2.5mg and whether it improves hair loss treatment. They are seeking experiences from others who have tried higher doses.

community Finally progress! - 4 month on 1.25mg FIN (daily) + MIN + Dermarolling

in Progress Pictures 198 upvotes 11 months ago

The conversation discusses a user's progress after 4 months of using 1.25mg finasteride daily, minoxidil, and dermarolling to treat hair thinning, particularly on the sides and crown. The user believes finasteride made the most difference, and they share tips on managing hair loss and tracking progress.

community C’est terrible - at my wits end

in Female 449 upvotes 1 year ago

A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

community I’m a female with aga and I don’t know what to do more , I’m hopeless

in Female 12 upvotes 1 year ago

Female with aga tried minoxidil 5% and spironolactone, no success yet. Gladyator96 suggests waiting 6 months, adding tretinoin or dermarolling with minoxidil.

community Anyone excited for CosmeRNA coming this month?

in Product 171 upvotes 1 year ago

CosmeRNA, a new hair loss treatment, is expected to release soon and may become part of the "big three" treatments alongside finasteride and minoxidil. It works differently from finasteride by targeting androgen receptors in hair follicles, potentially offering fewer side effects.

community How all hormones affect our hair follicles. Not just DHT. Take a look at this paper. Prolactin, melatonin, cortisol, progesterone, testosterone and more

in Research/Science 126 upvotes 2 years ago

The conversation discusses various factors affecting hair loss, not just DHT, and mentions treatments like Minoxidil, finasteride, and melatonin. Some users report personal experiences with these treatments and hormone tests, while others speculate on the role of hormones like prolactin and cortisol in hair loss.

community Last resort attempt. Studies suggest that finasteride topically actually inhibits up to 52% scalp dht which is smiles to dut 0.5mg daily. This solution contains: fin, min, melatonin and progesterone. Trial started today.

in Research/Science 8 upvotes 2 years ago

The conversation discusses a last-resort hair loss treatment combining topical finasteride, minoxidil, melatonin, and progesterone, with claims that topical finasteride can inhibit up to 52% of scalp DHT. One reply clarifies that progesterone is not an anti-androgen but has anti-androgenic properties because it competes with androgens for receptors.

community P5P supplementation for fin sides.

in Treatment 7 upvotes 2 years ago

P5P supplementation helped reverse finasteride side effects, particularly by lowering prolactin levels and restoring sensitivity. The user experienced significant improvement within a day and full recovery in a few days.

community 26M Baseline blood work done before Finasteride

in Finasteride/Dutasteride 8 upvotes 3 years ago

A person considering finasteride for hair loss checked their hormone levels before starting treatment. They are concerned about the potential increase in estradiol and its effects, as well as the impact on their sex hormone-binding globulin (SHBG) and free testosterone levels.

community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

in Female 42 upvotes 3 years ago

User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

community Glycine supplementaion is said to strongly upregulate 5-alpha Reductase (5-ar) Activity

in Research/Science 15 upvotes 4 years ago

Glycine supplementation may increase 5-alpha reductase activity, potentially affecting hair loss. Users discuss its impact on hair fall and its role in the body.

community Please take a vitamin & hormone test

in Chat 256 upvotes 1 week ago

Checking vitamin and hormone levels is important for addressing hair loss, as deficiencies in vitamin D, zinc, and iron can affect hair growth. Treatments like finasteride, minoxidil, and vitamin supplements are used, but addressing deficiencies is crucial for effectiveness.