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    GlossarySkin Tissue (Dermal Tissue)

    outermost protective layer of the body

    Skin tissue, also known as cutaneous tissue, is the body's largest organ and serves as a protective barrier against environmental hazards. It consists of three primary layers: the epidermis (outer layer), dermis (middle layer), and hypodermis (subcutaneous layer). These layers work together to protect internal organs, regulate temperature, and provide sensory information.

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      community The Big Fat Layer / Remedies: Cetirizine

      in Treatment  11 upvotes 3 years ago
      Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.

      community The Big Fat Layer II

      in Research/Science  26 upvotes 3 years ago
      Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

      community Update: 16 months deep - big 3

      in Progress Pictures  407 upvotes 11 months ago
      The user has seen positive results after 16 months of using topical Finasteride/Minoxidil, microneedling weekly, and Tretinoin for hair loss. There are no reported side effects, and the user advises that the effectiveness of microneedling depends on the pressure applied.

      community Hair theory Scar tissue and Verteporfin

      in Chat  25 upvotes 3 months ago
      A user suggests that deeper microneedling with Verteporfin injections might help regrow hair in areas with scar tissue, alongside a DHT blocker. Another user explains that hair loss might be due to reduced Wnt/β-Catenin signaling and suggests that treatments like Minoxidil, Finasteride, and microneedling could potentially reverse it.

      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  743 upvotes 1 year ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community Tropoelastin injections + verteporfin?

      in Research/Science  12 upvotes 1 year ago
      The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Vitamin C and hair growth PH levels

      in Product  34 upvotes 2 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community What's your option on complementary treatment

      in Product  3 upvotes 3 months ago
      The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 7 months ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Verteporfin and Microneedling

      in Treatments 3 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

      community Has anyone ever had success with just micro-needling?

      in Microneedling  20 upvotes 5 months ago
      People are discussing if microneedling alone can improve hair loss without using treatments like minoxidil, finasteride, or RU58841. Some users report moderate success with microneedling and natural remedies, but most suggest that results are better when combined with medical treatments.

      community Comprehensive Microneedling Guide

      in Microneedling  291 upvotes 2 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 1 month ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Testosterone in Reference Range Doesn't Cause Hair Loss

      in Research/Science  51 upvotes 8 months ago
      Testosterone within the normal range does not significantly contribute to male pattern baldness (MPB); DHT is the main factor that can be controlled. Genetics play a crucial role in hair loss, and treatments like finasteride and dutasteride, which block DHT, can help despite potentially raising testosterone levels.

      community It’s getting worse. (4 months)

      in Update  203 upvotes 9 months ago
      The conversation discusses hair loss treatments, with users suggesting the use of finasteride daily, considering minoxidil for aggressive hair loss, and discussing the normalcy of shedding during treatment. Some users recommend adding Nizoral shampoo and switching to dutasteride for better results.

      community This is the best time in human history to be fighting hair loss

      in Treatment  192 upvotes 2 years ago
      This conversation discusses the advancements in treatments for hair loss, including finasteride, dutasteride, minoxidil and new promising treatments such as pyrilutamide and verteporfin. Other treatments discussed were taking minoxidil orally, tretinoin to turn non-responders into responders and microneedling to further boost growth.

      community Hair loss causes are still a myth.

      in Chat  16 upvotes 2 years ago
      The conversation discusses the complexity of hair loss causes, suggesting that DHT sensitivity alone doesn't fully explain it. Treatments mentioned include finasteride and dutasteride.