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GlossaryAndrogen Receptor

protein in cells that binds male hormones to regulate genes

The androgen receptor (AR) is a type of protein found inside cells that binds to androgens, which are male hormones like testosterone and dihydrotestosterone. This binding activates the receptor, allowing it to enter the cell nucleus and influence the expression of specific genes, playing a crucial role in the development and maintenance of male characteristics, as well as in conditions like androgenic alopecia (male pattern baldness).

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community Testosterone before and after take fin/dut

Majestic_Variety9325 in Finasteride/Dutasteride 239 upvotes 1 year ago

User experienced 100% testosterone increase after using Finasteride and Dutasteride for hair loss. Some users discuss potential side effects and reasons for the increase.

community Kintor has announced the results for their human Phase I trials of GT20029

poiuytrewq_poiuytrew in Research/Science 253 upvotes 2 years ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community Diffuse thinning fucking sucks

apurplesnake in Update 430 upvotes 11 months ago

The conversation discusses various treatments for hair loss, including finasteride, minoxidil, dutasteride, microneedling, and checking for nutrient deficiencies. Some users suggest adding hydrocortisone butyrate, low-dose progesterone, or tretinoin to treatment regimens, while others recommend cosmetic solutions like Toppik hair fibers or shaving the head.

community Sup lads. Needing some Pyrilutamide updates.

shegotaloosepussay in Research/Science 17 upvotes 2 years ago

Hair loss treatments, specifically Pyrilutamide and Minoxidil/Finasteride/RU58841. Participants discussed their experiences with them and the results they have seen so far.

community Comeback form NW7?

dasmby in Progress Pictures 59 upvotes 4 years ago

A user shared their aggressive hair loss treatment regimen, which includes daily use of Avodart (dutasteride) and Minoxidil, bi-weekly use of Davines Purifying shampoo, and almost daily use of Ducray Anaphase+ shampoo, along with supplements like vitamin D3, collagen, biotin, and zinc. They also use a dermastamp every 10 days and are considering a hair transplant for increased density, followed by a switch to finasteride and Minoxidil foam.

community The Big Fat Layer II

baaldaa in Research/Science 26 upvotes 4 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community Kintor’s KX-826 Pyrilutamide!!

DaarkKnight001 in Research/Science 150 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community Next month marks 2 years on Dutasteride. When does it start working?

Foreign_Fondant_2880 in Finasteride/Dutasteride 36 upvotes 8 months ago

A user has been on dutasteride for nearly 2 years with no improvement in hair loss, expressing frustration. Other users suggest checking for other health conditions, getting bloodwork, and considering stopping TRT or trying finasteride.

community It's over. Hairline has fallen. Millions must shave.

Wrong_Ad1113 in Update 467 upvotes 1 year ago

The conclusion of the conversation is that the user has tried various medications and treatments for hair loss, including minoxidil, finasteride, microneedling, and nizoral shampoo, but has not seen any progress. They have decided to shave their head. Other users suggest options such as hair transplants, RU58841, hair units, and scalp micropigmentation.

community 4600 - result 9 month - Dr. Carman

Felix8020 in Progress Pictures 253 upvotes 1 year ago

A user shared their 9-month post-hair transplant results with 4600 grafts, using only Nourkin hair vitamins, Vitamin D, and B12, and expressed satisfaction. The replies debated the necessity of medications like finasteride and minoxidil for maintaining hair health.

community 3 month using minoxidil 5% once a day

Few-Situation9978 in Progress Pictures 304 upvotes 1 month ago

Using minoxidil 5% once a day for hair loss, with suggestions to add finasteride for better results. It also discusses the effectiveness and side effects of finasteride and the importance of consistent application.

community KX-826: Long-Term Safety Results are out!

NikNak531 in Research/Science 159 upvotes 3 months ago

KX-826 initially improves hair growth but declines after 24 weeks, with mild itching as a side effect. Combining it with minoxidil and finasteride may improve results, but long-term effectiveness is uncertain.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

MagicBold in Research 413 upvotes 2 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

MagicBold in Research/Science 2 upvotes 2 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Kintor Pharma Announces Completion of Patient Enrollment in Phase II Clinical Trial of GT20029 for Treatment of Androgenetic Alopecia in China

dannar2003 in Research/Science 88 upvotes 1 year ago

Kintor Pharma completed patient enrollment for a Phase II trial in China for GT20029, a potential new treatment for hair loss. Some believe GT20029 could replace finasteride if effective, while others discuss finasteride's limited efficacy and potential underreported side effects.

community Shedding again after 6 months of great results.

jdespirito in Minoxidil 15 upvotes 5 months ago

A user experienced shedding after 7 months on Fin/Min spray despite good results and no change in treatment. Other users noted similar experiences and mentioned that shedding periods can be normal.

community Would you continue to use Finasteride and Minoxidil once HMI 115 becomes available?

United_Citron8474 in Research/Science 5 upvotes 8 months ago

The conversation discusses the potential use of HMI 115 for hair loss and whether it could replace or be used alongside finasteride, minoxidil, and RU58841. The user is experiencing scalp inflammation and continued hair shedding despite using finasteride for 8 years.

community [30M] 4 Months of Progress Oral 3MgMin&1.1MgFin + .5mm Derma Roller Mondays and Fridays

Admirable-Hour-3238 in Progress Pictures 161 upvotes 7 months ago

A user shared their 4-month progress using oral Minoxidil (3mg) and Finasteride (1.1mg) with a 0.5mm derma roller twice a week, noting visible improvement. Others congratulated and encouraged them to continue the treatment.

community Prolactin’s role in antitumor activity of the immune system – a safety concern for HMI-115?

themainheadcase in Research/Science 3 upvotes 1 year ago

Hair loss discussion includes treatments Minoxidil, Finasteride, and RU58841. Prolactin's role in immune system's antitumor activity raises safety concerns for HMI-115.

community Losing hair as teenager Dont know what to do

Firm-Beginning-7808 in Chat 3 upvotes 1 year ago

A teenager started balding at 13 and has been using minoxidil for 2 years, but the hair loss is returning. They are seeking advice on additional treatments. Another user suggests finasteride or shaving the head, and emphasizes the importance of not letting hair loss affect self-esteem and relationships.

community Found this meme on a forum……..

alittlelessconversa in Satire 150 upvotes 1 year ago

The conversation is about a meme related to hair loss that influenced someone to start taking finasteride. Another person agrees that the meme accurately represents the situation.

community Do People even realize that we got a new Treatment Option and Kintor Officially released Pyrilutamide?

Worth-Beat-1953 in Treatment 56 upvotes 6 months ago

A new hair loss treatment, Pyrilutamide, has been released and is claimed to be a strong anti-androgen, potentially effective when used with finasteride. However, there are mixed opinions on its effectiveness and safety, with some users skeptical and others purchasing it.

community Concerns about CosmeRNA safety mechanisms

Civil-Negotiation27 in Treatment 3 upvotes 1 year ago

Concerns about CosmeRNA safety mechanisms and potential side effects. Discussion includes comparisons to Fluridil and questions about nanoparticle specificity and siRNA stability.

community How long until pyrilutamide or gt20029 get FDA approved?

Known-Care-271 in Research/Science 7 upvotes 1 year ago

Hair loss treatments pyrilutamide and GT20029 discussed. Pyrilutamide approval in 2 years, GT20029 in 5-6+ years.

community Hair loss and ethnicity - Caucasian men the most likely to experience hair loss

Dvine24hr in Chat 17 upvotes 2 years ago

The conversation discusses how Caucasian men are more likely to experience hair loss due to genetic predisposition, with factors like the androgen receptor on the X chromosome playing a significant role. The user also expresses confusion about the evolutionary reasons for hair loss, especially in colder climates where it would seem beneficial to retain hair for warmth.

community It’s over. NOTHING has worked.

thejaketor in Chat 95 upvotes 2 years ago

A user who has been trying various treatments for hair loss for four years, with no success. Suggestions include use of minoxidil, finasteride, RU58841, microneedling, supplements and multivitamins, lifestyle changes, scalp biopsy, and SMP.

community Maintaining hair until Breezula without Fin

hairgodshavemercy in Treatment 6 upvotes 4 years ago

A 21-year-old male experienced side effects from topical finasteride and is seeking alternative treatments to maintain hair until Breezula is available. He is considering using minoxidil, Nizoral, micro-needling, and vitamin D supplementation, and may try CB or RU58841 if necessary.

community How to know if shedding is from tren or minoxidil?

thesausage58 in Minoxidil 5 upvotes 10 months ago

The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

community I really hate how current hair loss treatment only rely on DHT blockers

Significant_Web1562 in Finasteride/Dutasteride 76 upvotes 1 year ago

The conversation discusses dissatisfaction with current hair loss treatments that mainly focus on DHT blockers like finasteride and dutasteride. Alternative treatments mentioned include RU58841, pyrilutamide, minoxidil, rosemary oil, and future possibilities like hair cloning.

community Pattern hair loss could be due to gut bacteria

Paarebrus 48 upvotes 5 years ago

Feeding bacteria-free mice with Lactobacillus murinus worsened hair loss, but a regular diet with biotin stopped it. The conversation suggests gut bacteria and diet may influence hair loss, with some skepticism and discussion about other factors like DHT and genetics.