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GlossaryAndrogen Receptor

protein in cells that binds male hormones to regulate genes

The androgen receptor (AR) is a type of protein found inside cells that binds to androgens, which are male hormones like testosterone and dihydrotestosterone. This binding activates the receptor, allowing it to enter the cell nucleus and influence the expression of specific genes, playing a crucial role in the development and maintenance of male characteristics, as well as in conditions like androgenic alopecia (male pattern baldness).

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community The Real Cause Of Androgenetic Alopecia

AccutaneEffectsInfo in Research/Science 673 upvotes 3 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community How long until pyrilutamide or gt20029 get FDA approved?

Known-Care-271 in Research/Science 7 upvotes 1 year ago

Hair loss treatments pyrilutamide and GT20029 discussed. Pyrilutamide approval in 2 years, GT20029 in 5-6+ years.

Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens

MagicBold in Research 413 upvotes 2 months ago

Treating androgenic alopecia with minoxidil, finasteride, and antiandrogens, alongside exercise, cryotherapy, and natural substances to stimulate cold receptors for better hair growth. The method focuses on enhancing treatment effectiveness by considering environmental and behavioral factors and the role of cold receptors and muscle stress.

community Physio-metabolic method of treating androgenic alopecia. Cold receptors. The relationship between DHT, cold receptors, minoxidil and antiandrogens.

MagicBold in Research/Science 2 upvotes 2 months ago

A method for treating androgenic alopecia using minoxidil, antiandrogens, exercise, and cold exposure to promote hair growth. Environmental factors and lifestyle changes, like diet and exercise, can improve treatment effectiveness.

community Long term finasteride users; Did you notice any improvement after 2 years?

SimmaG98 in Finasteride/Dutasteride 14 upvotes 1 year ago

Long term Finasteride users and whether or not they have noticed improvements after two years of use, with other treatments such as Minoxidil and dermarolling also discussed. Some replies suggest that improvement is possible even beyond the two year mark while others caution against believing studies backed by the Post-Finasteride Foundation.

community 1 month Pyrilutamide. A non responders story to everything.

Combfromhell in Research/Science 218 upvotes 2 years ago

My hairline, I am only 23. This conversation is about a user's experience with treatments for androgenic alopecia, including finasteride, dutasteride, RU, minoxidil, progesterone, melatonin, LLLT, oral minoxidil, and Pyrilutamide. They have tried many treatments over the course of two years without seeing much success, and they are considering getting a hair system as a last resort.

community Creatine's effect on Hair Loss and DHT

azraelmick39 in Research/Science 101 upvotes 11 months ago

A 21-year-old male managed to control his hair loss using Nizoral, RU58841, and finasteride, but experienced increased scalp itchiness after starting creatine, which subsided upon stopping creatine. Users shared mixed experiences on whether creatine affects hair loss, with some reporting negative effects and others seeing no change or defending its benefits.

community Is hairloss due to vitamin D deficiency reversible?

blablagoolooga in Treatment 12 upvotes 3 years ago

Hair loss treatments include finasteride and spironolactone. Low vitamin D levels may contribute to hair loss, and normalizing levels could potentially help regrowth.

community Is GT20029 a cure for further hairloss? Also what do you estimate its price to be?

chattopaddhay in Research/Science 9 upvotes 1 year ago

The conversation discusses the potential of GT20029 to stop hair loss and possibly regrow hair, considering the body's regenerative abilities. No specific treatments were mentioned due to the original post being removed.

community Whats up with all the dutasteride destroying hair posts

Basic_Football999 in Finasteride/Dutasteride 64 upvotes 1 year ago

User Basic_Football999 discusses concerns about negative dutasteride experiences. Replies suggest dutasteride is effective, but some users may have issues with dosing frequency or genetic factors affecting results.

community Signs of life. Ru, topical fin/min, mk677, micro needling

Rancorpiss in Progress Pictures 192 upvotes 3 years ago

The conversation discusses using RU58841, topical finasteride/minoxidil, MK677, and microneedling as treatments for hair loss. MK677 is mentioned as a growth hormone that improves hair health and recovery from microneedling.

community Kintor’s GT20029 Phase 1 success

Busy_Trick_6366 in Update 75 upvotes 2 years ago

Kintor's GT20029, a treatment for hair loss, has completed Phase 1 successfully, showing promise as an androgen receptor degrader that could potentially regrow hair. It is considered more effective than Pyrilutamide, with infrequent dosing and minimal systemic absorption.

community Natural Remedies: Polyphenols and Hair Loss

jrz302 18 upvotes 5 years ago

Natural remedies to treat hair loss, such as polyphenols, apple peel extract, grape seed extract, green tea extract, peppermint oil, pumpkin seed oil, apigenin, Ginkgo biloba, red clover extract, olive leaf extract, Ecklonia Cava and Grateloupia elliptica. In addition, terpenes, carotenoids, and tocopherols were discussed as potential treatments.

community Kintor has announced the results for their human Phase I trials of GT20029

poiuytrewq_poiuytrew in Research/Science 253 upvotes 2 years ago

The conversation discusses the potential of a new hair loss treatment, GT20029, which may prevent hair loss by destroying androgen receptors on the scalp. Users express hope for the treatment's success and speculate on its usage routine, effectiveness, and possible side effects.

community U.S Court let Merck hide secrets about Finasteride.

EnbyBinaryCoder in Finasteride/Dutasteride 303 upvotes 1 year ago

Hair loss discussion involving finasteride's side effects and effectiveness. Users shared mixed experiences, with some reporting side effects and others seeing positive results.

community Anyone remember Breezula, the promising hairloss drug that was perpetually 3 years away? Well, it's available right now as an acme treatment. Can we just directly apply to the scalp?

StoryTooMuch in Treatment 39 upvotes 3 years ago

The conversation discusses the availability of Breezula, a drug for hair loss, now being sold as an acne treatment, and whether it can be applied to the scalp. Users express skepticism about new hair loss treatments and suggest waiting for FDA approval.

community 0.5mg Dutasteride promotes more “regrowth” than 5mg oral Minoxidil

Villanellat in Research/Science 117 upvotes 1 year ago

Dutasteride promotes more hair regrowth than Minoxidil. Users discuss combining treatments for better results and share personal experiences with side effects.

community What are you thinks about new treatment methods and development in hair lose ? such as; Breezula

ltfllh58 in Research/Science 11 upvotes 2 years ago

The conversation discusses new hair loss treatments, mentioning Breezula and a promising treatment called pyrilutamide.

community Helicobacter's concocted serum v1

Helicobacter 8 upvotes 5 years ago

A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

community New and Interesting HairLoss Studies/Papers/Reviews

TerpsandCaicos in Treatment 41 upvotes 5 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community 21M with a nasty case of MPB; Heres what's on my radar for the future.

The-Minoxidil-Max in Research/Science 14 upvotes 2 years ago

Hopeful treatments for hair loss, including Verteporfin, Androgen Receptor Degradation, and SCUBE3. These treatments offer potential solutions to slow or stop the effects of androgens on the scalp.

community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

Synizs in Research/Science 134 upvotes 9 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community Does CosmeRNA target the root cause of MPB?

CumsOnYourFeet69 in Chat 1 year ago

. CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

community It’s over. NOTHING has worked.

thejaketor in Chat 95 upvotes 2 years ago

A user who has been trying various treatments for hair loss for four years, with no success. Suggestions include use of minoxidil, finasteride, RU58841, microneedling, supplements and multivitamins, lifestyle changes, scalp biopsy, and SMP.

community How to know if shedding is from tren or minoxidil?

thesausage58 in Minoxidil 5 upvotes 10 months ago

The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

community Diagnosed with female pattern hair loss as a male with recent aggressive loss. Preemptively mourning the only part of myself I’ve ever come close to loving. Lost all motivation to do anything with my life.

AesopsTable2 in Progress Pictures 271 upvotes 1 year ago

The conclusion of the conversation is that the user should consider using treatments such as finasteride, minoxidil, and RU58841 to potentially reverse their hair loss. Other suggestions include using hair loss concealers and maintaining a healthy diet.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

HMI115_GIGACHAD in Research/Science 126 upvotes 1 year ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community Physician here AMA – 30M oral Fin 1-1.25 mg daily

BanksCarlton in Update 47 upvotes 2 years ago

Hair loss treatments, specifically the use of finasteride, microneedling and potentially oral minoxidil. People discussed their experiences with finasteride, its effects on sexual behaviors, as well as potential solutions such as tadalafil or using other growth factor signal peptides for hope in curing male pattern baldness.

community Why is dht bad for scalp hair but good for hair on the rest of body?

What_is_69 in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Genetics are so weird and unpredictable

crydancesinglaughmoo in Minoxidil 118 upvotes 2 months ago

The user experienced male pattern baldness starting at 18, tried finasteride with no success, and switched to dutasteride, which halted hair loss. Minoxidil had no effect for them, while their brother, who didn't use AR inhibitors, maintained a juvenile hairline and successfully grew a beard with minoxidil, highlighting the unpredictable nature of genetics in hair loss and treatment response.