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GlossaryAlpha-Melanocyte-Stimulating Hormone

peptide hormone that regulates skin pigmentation by stimulating melanin production

Alpha-Melanocyte-Stimulating Hormone (α-MSH) is a peptide hormone produced in the pituitary gland that plays a crucial role in regulating skin pigmentation by stimulating the production of melanin in melanocytes. It also has anti-inflammatory properties and can influence appetite and energy homeostasis.

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community Peptides that Stop Hair Loss? | In-depth Literature Review Video

in Research/Science 74 upvotes 5 months ago

Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.

community Alpha plus from Anagenica - 25%CB???

in Product 2 upvotes 1 year ago

A user ordered Alpha Plus from Anagenica, expecting it to contain specific percentages of Fin, Estradiol, Minoxidil, and CB0301. However, the received product's label showed different percentages, including a surprising 25% CB, leading the user to question its safety and accuracy.

community 17-alpha-estradiol/Alfatradiol how does it Work for Hair loss?

in Treatment 2 upvotes 5 days ago

17-alpha-estradiol may work for hair loss by inhibiting 5-alpha reductase, similar to finasteride. It might lower testosterone in the scalp, reducing DHT conversion.

community 5ar alpha reductase stimulation is different depending on whether it’s type 1 or 2

in Hair Systems 16 upvotes 1 year ago

The conversation discusses how different factors can stimulate type 1 and type 2 isoforms of 5-alpha reductase, which are enzymes linked to hair loss. Specific treatments mentioned include oral Dutasteride and topical Finasteride.

community Inhibition of 5 alpha-reductase activity in human skin by zinc and azelaic acid????

1 upvotes 6 years ago

The post discusses using a topical tincture containing zinc, azelaic acid, and other ingredients to inhibit 5 alpha-reductase activity for treating hair loss. The user plans to try this natural alternative before using finasteride or RU58841.

community Mechanism of action of alfatradiol (17 alpha estradiol)

in Research/Science 6 upvotes 6 months ago

The conversation discusses the mechanism of action of alfatradiol (17 alpha estradiol) in treating hair loss. It explores theories that it either inhibits 5 alpha reductase to prevent T->DHT conversion or aromatizes scalp T into 17-alpha-estradiol to save hair.

community Glycine supplementaion is said to strongly upregulate 5-alpha Reductase (5-ar) Activity

in Research/Science 15 upvotes 4 years ago

Glycine supplementation may increase 5-alpha reductase activity, potentially affecting hair loss. Users discuss its impact on hair fall and its role in the body.

community Which Saw Palmetto is good for blocking 5 alpha reductase, Serenoa repens or Chamaerops humilis?

in Finasteride/Dutasteride 4 years ago

The conversation is about determining which type of Saw Palmetto, either Chamaerops humilis or Serenoa repens, is effective for inhibiting the 5 alpha reductase enzyme related to hair loss. Specific treatments mentioned are Minoxidil, finasteride, and RU58841.

community What can I use to prepare a lotion that doesn't irritate my scalp or make my hair sticky? (Want to experiment with metformin and Alpha Keto glutarate)

in Product 2 upvotes 1 year ago

The conversation is about a user who tried dissolving a metformin pill in water for hair treatment but faced issues with hair sticking together. The user is seeking advice on preparing a non-irritating, non-sticky lotion at home, possibly experimenting with metformin and Alpha Keto glutarate.

community Me looking at my friends slight temple recession and calculating how long it'll take for him to bring it up to me, the Hairloss expert (I've been on finasteride for 6 months) so I can slap him with a 30 minute presentation about DHT miniaturization and 5-alpha reductase inhibitors

in Satire 536 upvotes 1 year ago

The post is a humorous take on the author's experience with hair loss and using finasteride for six months. The conversation includes discussions about hair loss, treatments like finasteride, and personal experiences with baldness.

community Anybody on here from Germany who can talk to us about alfatradiol (Avicis, Avixis, Ell-Cranell Alpha and Pantostin)? Availability, public perception, etc?

in Treatment 7 upvotes 3 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. A user asks about alfatradiol's availability, public perception, and usage in Germany.

community We need actual hair loss studies on Epristeride

in Research/Science 6 upvotes 1 month ago

Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalp DHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.

community Comparing the effect of T suppression and DHT suppression

in Transgender 61 upvotes 5 months ago

The conversation discusses the use of 5-alpha-reductase inhibitors like finasteride and dutasteride for hair loss in transgender women, particularly in relation to testosterone suppression. The original poster has been using dutasteride and is considering stopping it due to undetectable testosterone levels.

community Do these two supplements inhibit 5alpha-reductase?

in Chat 1 upvotes 4 years ago

Pumpkin Seed Oil and Perilla Oil (with alpha-lipoic acid, linoleic acid, and oleic acid) are discussed as potential 5alpha-reductase inhibitors. The conversation focuses on their effectiveness for hair loss treatment.

community ghk-cu is potent 5-ar inhibitor?

in Product 9 upvotes 10 months ago

GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

community Allopregnanolone deficiency by 5-ari inhibition (fin/dut users)

in Finasteride/Dutasteride 11 upvotes 1 year ago

The conversation is about managing allopregnanolone deficiency caused by 5-alpha-reductase inhibitors like finasteride or dutasteride. Specific treatments discussed for hair loss include Minoxidil, finasteride, and RU58841.

community telogen effluvium hair loss. Has anyone had it and could tell me anything about it?

in Treatment 1 upvotes 4 years ago

The user experienced hair thinning from chromium and alpha lipoic acid supplements, which stopped after discontinuing them. Someone mentioned this could be telogen effluvium, a temporary condition.

community Is it possible to develop noticeable thinning in a month?

in Am I balding? 4 years ago

A user experienced hair loss after taking chromium and alpha lipoic acid supplements but stopped shedding after discontinuing them. They noticed thinning around the temples and started dermarolling.

community Theoretically won't this be better than finasteride? Azelaic acid + zinc

in Research/Science 8 upvotes 1 year ago

The conversation discusses using zinc sulphate and azelaic acid to inhibit 5 alpha-reductase activity, which could potentially treat androgen-related skin conditions like hair loss. Combining these with vitamin B6 could enhance the effect, potentially offering an alternative to finasteride.

community Take multivitamins if you have sexual side effects! it's amazing

in Product 20 upvotes 3 years ago

A user shared that taking multivitamins, specifically Myprotein "Alpha Man," improved their sexual energy while on finasteride. They believe the benefits come from Zinc and Vitamin B6/12.

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

in Research/Science 14 upvotes 1 year ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community Nice & pure PRP, 3 ml of this is going to the scalp.

in Research/Science 32 upvotes 2 years ago

The use of PRP to treat hair loss and its potential effectiveness when combined with 5 alpha reductase blockers such as Minoxidil or Finasteride.

community The first three months on minoxidil 2%

in Is this regrowth? 1 upvotes 2 months ago

The user noticed hair thinning and has been using a treatment with minoxidil 2%, hydrocortisone butyrate, and 17 alpha estradiol for three months, seeing some regrowth. The user had dermatitis, now cured, which worsened the hair loss.

community I think we all hop on estrogen. It's the only angle

in Satire 83 upvotes 4 months ago

The conversation humorously discusses hair loss treatments, including Minoxidil, finasteride, RU58841, and topical 17 alpha estradiol, with some users joking about transitioning to female to avoid baldness. The overall tone is satirical, emphasizing self-acceptance and the lengths people might consider for hair restoration.

community Microneedling only with rosemary

in Microneedling 6 months ago

A user asked if microneedling, massages, and essential oils can prevent further hair loss in the crown area without using drugs. The response indicated that without a 5-alpha-reductase inhibitor, hair loss will likely continue.

community 2 month progress with Minoxidil and Dermaroller

in Minoxidil 412 upvotes 10 months ago

The conversation discusses a user's two-month hair regrowth progress using Minoxidil and a 0.5mm dermaroller. Some suggest adding a 5-alpha-reductase inhibitor like finasteride or dutasteride to maintain the results.

community Blood DHT Levels – before and after creatine

in Research/Science 41 upvotes 1 year ago

The impact of creatine on DHT levels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5 alpha reductase inhibitor found that their DHT levels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.

community Self-Experiment - Topical Rapamycin or a-KB

in Treatment 5 upvotes 3 years ago

A user plans to create a DIY topical treatment for hair loss using Rapamycin, possibly combined with alpha-ketoglutaric acid (a-KG). They discuss the concentration and formulation process for Rapamycin, considering safety and skin penetration, and intend to apply it every other day to the scalp.

community Topical rapamycin, metformin, a-kg grow hair

in Research/Science 13 upvotes 4 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

community 19M started minoxidil 5% and dermarolling 4 months ago. First pic is the end of my first month (january 21) and the second is today (april 21). I apply minoxidil 2 times a day and dermaroll 0.5mm once a week. Thoughts?

in Progress Pictures 71 upvotes 8 months ago

A 19-year-old male has been using minoxidil 5% and dermarolling for four months to treat hair loss, applying minoxidil twice daily and dermarolling once a week. Commenters suggest consistent treatment, improving picture quality, and adding a 5-alpha-reductase inhibitor to enhance results.