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GlossaryDopamine Agonists (DA agonists)

medications that mimic dopamine by stimulating its brain receptors

Dopamine agonists, also known as dopamine receptor agonists or DA agonists, are medications that mimic the action of dopamine by stimulating dopamine receptors in the brain. They are commonly used to treat conditions like Parkinson's disease and restless legs syndrome by compensating for low dopamine levels, thereby improving symptoms such as motor control and mood.

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community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 3 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I've been afflicted by post finasteride syndrome, what now?

in Finasteride 42 upvotes 5 years ago

A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.

community 4 months (topical min, .5 dermastamp once a week, ketoconazole shampoo)

in Progress Pictures 726 upvotes 10 months ago

A user shared their positive hair regrowth results after 4 months using topical minoxidil, a 0.5 dermastamp once a week, and ketoconazole shampoo. Some responses suggest adding finasteride to maintain results, while others praise the effectiveness of the treatments used.

community Did anyone try natural hair masks while on Finasteride?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation is about using natural hair masks like red hot pepper, aloe vera, onion juice, mint oil, and valerian root alongside finasteride for hair loss. The user is asking if anyone has tried these and seen positive effects.

community Is GT20029 supposed to regrow hair as well?

in Treatment 10 upvotes 1 year ago

The user is considering switching from finasteride to dutasteride for hair loss. They are unsure if GT20029 can regrow hair, particularly on the temples. Another user mentions that regrowth on finasteride can take up to 2 years.

community When someone posts a scalp tension theory

in Satire 265 upvotes 3 years ago

Hair loss theories discussed include poor blood flow, scalp tension, inflammation, and DHT. Treatments mentioned are massaging scalp, minoxidil, finasteride, and RU58841.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 43 upvotes 2 months ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community HMI 115 Phase 2 - Leaked pics from Discord

in Research/Science 358 upvotes 6 months ago

The conversation discusses HMI 115, a new hair loss treatment with promising results, showing a significant increase in hair density after two months. Some users are skeptical, while others are hopeful for its release and potential affordability.

community What should we lookout for in the near future for hairloss?

in Research/Science 17 upvotes 1 year ago

The user is using finasteride and minoxidil for hair loss but is looking for new treatments. Pyrilutamide and GT20029 are potential future treatments, with Pyrilutamide expected next year and GT20029 possibly by 2027.

community Why HMI115 should work if it doesn’t affect dht?

in Research/Science 16 upvotes 1 year ago

Hair growth can be induced without stopping DHT, as seen with Minoxidil. HMI115 may work by promoting follicle growth, not targeting the root cause of hair loss (DHT).

community What are you thinks about new treatment methods and development in hair lose ? such as; Breezula

in Research/Science 11 upvotes 2 years ago

The conversation discusses new hair loss treatments, mentioning Breezula and a promising treatment called pyrilutamide.

community If we lose hair because of our sensitivity to DHT, then why are we trying to reduce DHT when our sensitive androgen receptors are the culprit?

in Finasteride/Dutasteride 13 upvotes 2 years ago

The conversation discusses the effectiveness of reducing DHT for hair loss treatment and explores alternative approaches like reducing androgen receptor sensitivity. Specific treatments mentioned include finasteride, dutasteride, pyrilutamide (KX-826), GT20029, and RU58841.

community Hair Loss Treatment Iceberg Chart

in Satire 1379 upvotes 2 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, ass hair transplant, topical Viagra, castration, and transitioning to female. A user mentions an experimental drug called M4U-5 (Mousteride) that turns you into a mouse.

community Does microneedling regrow hair on dormant bald regions which have been bald for many years?

in Microneedling 6 upvotes 4 years ago

Microneedling may help regrow hair in dormant bald regions by stimulating stem cell transfer. Users discuss its effectiveness and how collagen might aid in the process.

community Is it ok to take Xeljanz (A jak inhibitor) while taking finasteride?

in Finasteride 2 upvotes 7 years ago

The conversation is about whether it is safe to take Xeljanz, a JAK inhibitor, while also taking finasteride for hair loss. The concern is that Xeljanz weakens the immune system, which could be risky.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 4 weeks ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community What would hair loss treatment be like in the 2030s?

in Treatment 5 upvotes 4 months ago

The conversation discusses future hair loss treatments, with mentions of dutasteride potentially gaining FDA approval and increased popularity. Skepticism remains about significant advancements due to limited funding and reliance on cosmetic companies.

community How to know if shedding is from tren or minoxidil?

in Minoxidil 5 upvotes 7 months ago

The user started using trenbolone and minoxidil simultaneously and experienced increased hair shedding, unsure which is causing it. Replies suggest both drugs could cause hair loss, with one advising to stop trenbolone to protect hair and another indicating minoxidil is unlikely the cause due to the timing.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 160 upvotes 10 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community hmi115 is coming. Prepare yourselves for what's coming

in Technology 107 upvotes 1 year ago

The conversation discusses HMI-115, a potential cure for hair loss. Users share mixed opinions, with some expressing skepticism and others sharing anecdotal evidence of its effectiveness, including photos of significant hair regrowth from a trial participant.

community Nandrolone Replacement Therapy

in Treatment 41 upvotes 1 year ago

A user discusses starting nandrolone replacement therapy to stop hair loss and improve hair health, noting its benefits over finasteride. They report halted hair loss, improved skin, increased muscle, and a calm mood after three weeks.

community NW4 -> NW 2.5 (2.5 months progress) RU 8.5-9% ED and topical Dut .1% + RU 5% once a week.

in Progress Pictures 106 upvotes 1 year ago

User shows hair loss progress from NW4 to NW2.5 in 2.5 months using RU 8.5-9% daily and topical Dut .1% + RU 5% weekly. Discussion includes managing tension in African American hair and representation of different hair types.

community [Research/Science] What's the General Consensus On Pyrilutamide So Far?

in Research/Science 8 upvotes 1 year ago

Pyrilutamide is considered to work for hair loss but less effectively than expected, similar to RU58841, and may cause side effects like chest tightness and sexual issues. It's unclear if it's suitable for diffuse thinners, and one user cannot use minoxidil or finasteride due to side effects and personal circumstances.

community (UPDATE) 9 month progress on Minoxidil 5%(switched to 10% last 3months) and Finasteride 1mg per day, everyday.

in Progress Pictures 138 upvotes 2 years ago

User shared 9-month progress using Minoxidil 5% (switched to 10% last 3 months) and Finasteride 1mg daily for hair growth. Experienced improvement in hair volume, but crown still not fully filled; considering transplant if no further progress.

community First 100 days of Fin/Min/Niz/Microneedling 30M

in Progress Pictures 324 upvotes 2 years ago

Hair loss treatment with Fin/Min/Niz/Microneedling showed great results in 100 days. User suggests adding topical rosemary oil and oral castor oil for extra benefits.

community 6month update – it’s not much but it’s honest work (Fin/Min/Nizoral/Dermaroll) hair slightly thicker, waiting for my crown to fill 🤞

in Progress Pictures 175 upvotes 3 years ago

User reports 6-month progress using Fin, Min, Nizoral, and Dermaroll for hair loss. Others comment on visible improvement and suggest waiting up to 2 years for full effects.

community Kintor’s KX-826 Pyrilutamide!!

in Research/Science 152 upvotes 3 years ago

KX-826 hair loss treatment completed trials with mild side effects. GT20029 may be ultimate cure, destroying androgen receptors causing baldness.

community How much dht does Nizoral shampoo block?

in Ketoconazole 101 upvotes 3 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, and Nizoral shampoo. Nizoral's effectiveness is debated, with some suggesting it works as a weak antagonist for androgen receptors, while others attribute its benefits to anti-fungal and anti-inflammatory properties.

community Success sttory – 22 to 27

in Progress Pictures 4 years ago

A user's success story of improving their hair loss with treatments that include finasteride, dutasteride, minoxidil, nizoral, and dermastamping; other products that have been tried with varying results; and potential side effects.

community Why haven’t we seen anything about this

in Research/Science 19 upvotes 4 years ago

A double blind, placebo-controlled study that looked into the potential effectiveness of topical fluridil for treating male androgenetic alopecia, showing increased anagen to telogen ratios with no reported side effects on libido or sexual performance.