This study reported the first known occurrence of citrulline in an animal protein, specifically in the fibrous protein of hair follicle inner root sheaths.
62 citations
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December 2007 in “Journal of biological chemistry/The Journal of biological chemistry”
This study found that enzymatic conversion of Arg-51 in S100A3 protein to citrulline promotes homotetramer assembly, potentially increasing Ca²⁺ binding required for hair cuticular barrier formation.
46 citations
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November 1963 in “Journal of Histochemistry & Cytochemistry”
In this study, researchers localized arginine and citrulline in rat hair follicles and found that arginine is abundant in trichohyalin droplets, while citrulline predominantly accumulates in the hardened inner sheath and medulla.
A user shared their positive experience with hair transplants by Dr. Craig Barton, having undergone two surgeries totaling 3,600 grafts for $12,000. They have been using finasteride and dutasteride for maintenance but stopped using minoxidil due to shedding issues.
Shiseido's S-DSC Hair Multiplication Treatment in Japan is available to foreigners but is expensive and not very effective. Despite past disappointments, there is hope for future treatments with more options in development beyond Minoxidil and Finasteride.
Microneedling at 0.6mm depth every two weeks showed better hair growth results than using minoxidil alone. Using a derma pen is recommended over a roller to avoid scarring.
Some users believe creatine may cause hair loss, citing anecdotal evidence and criticizing study flaws. Others argue there's no proven link between creatine and hair loss, suggesting any shedding might be due to other factors or genetic predisposition.
A 19-year-old diagnosed with AGA was refused finasteride by a dermatologist who cited fertility concerns and prescribed minoxidil, vitamins, and shampoos instead. The user is unsure about using minoxidil and considers finding another dermatologist.