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Glossary Chromosome 17

contains genes crucial for cell growth and DNA repair

Chromosome 17 is one of the 23 pairs of chromosomes in humans and contains approximately 83 million base pairs, which represent about 2.5% of the total DNA in cells. It is notable for housing several important genes, including those related to the production of proteins involved in cell growth, DNA repair, and the development of the nervous system. Mutations or alterations in genes on Chromosome 17 can lead to various medical conditions, such as certain types of cancer and neurological disorders.

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Research

5 / 1000+ results

research A group of type I keratin genes on human chromosome 17: characterization and expression.

141 citations , February 1988 in “Molecular and Cellular Biology”

This study found that despite strong homology between two K16 genes, only one encoded a functional protein that assembled into keratin filaments in epithelial cells, possibly due to promoter strength differences.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

This study identified a cluster of genes on chromosome 17 related to hair keratin-associated proteins, including 37 genes forming seven multigene families, localized in the hair shaft's upper cortex.

research 494 Congenital generalized hypertrichosis with a copy number variation on chromosome 17q24

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

This case report identified a 6-month-old girl with congenital generalized hypertrichosis and gingival hyperplasia, where a de novo CNV on chromosome 17q24.2-24.3 was associated with reduced expression of ABCA5 and SOX9.

research Whole-genome SNP genotyping mapped a novel locus for hereditary hypotrichosis on chromosome 2q31.1–q32.2

May 2015 in “Journal of Dermatological Science”

Researchers found a new area on chromosome 2 linked to a genetic hair loss condition.

research A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression

38 citations , February 1988 in “Molecular and Cellular Biology”

This study found that among the two highly homologous K16 genes on chromosome 17, only one produced a functional protein due to stronger promoter activity.

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Community Join

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community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

6 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community The meds work: my dad at 23 yo vs me at 35 yo

1791 upvotes 1 year ago

Finasteride and oral minoxidil effectively maintain a youthful appearance and full head of hair, despite genetic predispositions to balding. The discussion also considers the impact of DHT blockers on masculinity and aging, with lifestyle choices like sunscreen use and a vegetarian diet mentioned.

community Decades Update: age 23 to 25 and age 39 to 41

in Progress Pictures 725 upvotes 1 year ago

The user started using finasteride at age 23, stopped at 30 to start a family, and resumed at 39 with minoxidil, seeing positive results both times. They successfully had four children after stopping finasteride, noting changes in sperm quality and some side effects upon resuming the medication.

community My 2 Years Progress (Hair Recovery)

1465 upvotes 5 months ago

A person shared their hair regrowth journey using HIMS topical treatments with finasteride, minoxidil, hormone replacement therapy (HRT), and microneedling. They also discussed their transition as a transgender woman and the positive impact of HRT on hair recovery.

community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

13 upvotes 1 year ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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