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research Insertional mutation of the hairless locus on mouse Chromosome 14

19 citations , November 1993 in “Mammalian Genome”

This study reports that transgene insertion in homozygous transgenic mice causes irreversible hair loss and impaired immune function, linked to interruption of the hairless locus on Chromosome 14.

research A new case of Ambras syndrome associated with a paracentric inversion (8) (q12; q22)

28 citations , June 1998 in “Clinical Genetics”

This report describes a case of Ambras syndrome with a chromosomal inversion on chromosome 8, similar to a previous case, but not associated with altered androgen levels.

research Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene

January 2022 in “Mammalian Genome”

This study found that the wavy coat trait in Nakano cataract mice is polygenic, involving major and minor genes, and resembles human curly scalp hair associated with the PRSS53 gene alteration.

research Hox demarcates regional regeneration of adult hair follicle stem cells

June 2017 in “Mechanisms of development”

Hox genes control hair follicle stem cell regeneration in different body regions.

research The Complexity of the Ovine and Caprine Keratin-Associated Protein Genes

10 citations , November 2021 in “International journal of molecular sciences”

This review discusses the role of keratin-associated proteins in the growth and characteristics of wool and hair fibres from sheep and goats, and highlights areas for future research, but it presents no new findings.

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community Chromosome 20’s balding effects and why fin likely isn’t working for some.

in Treatment 96 upvotes 1 year ago

Finasteride is effective for DHT/AR-driven hair loss but not for chromosome 20-driven cases, where treatments like minoxidil, prostaglandin analogs, and low-level laser therapy may be more beneficial. Genetic testing can help determine the underlying cause of hair loss to tailor treatment effectively.

community Why Is No One Talking About Chromosome 20?

in Chat 32 upvotes 1 year ago

Some hair loss may be linked to chromosome 20, which isn't affected by DHT blockers like finasteride. Treatments like minoxidil, microneedling, and genetic testing are suggested, but their effectiveness for this type of hair loss is uncertain.

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