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research Structural changes of hair shaft after application of chemical hair straighteners: Clinical and histopathological study

7 citations , August 2018 in “Journal of cosmetic dermatology”

This study found that chemical hair straightening significantly reduced hair curl and improved smoothness and shine, but did not significantly affect transverse fissures or split ends, indicating potential benefits with some side effects.

research Effects of chemical straighteners on the hair shaft and scalp

2 citations , January 2022 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia”

This review discusses the effects of chemical hair straighteners and reports associated side effects like scalp inflammation and hair damage, noting the variability of findings and the need for further research.

Dose-Dependent Histopathological and Structural Impact of Chemical Hair Straighteners on Scalp Epithelium and Hair Fibers Using Albino Wistar Rats

research Dose-Dependent Histopathological and Structural Impact of Chemical Hair-Straighteners on Scalp Epithelium and Hair-Fibres Using Albino Wistar Rats

September 2025 in “Sahel Journal of Life Sciences FUDMA”

This study reported that albino Wistar rats exposed to chemical hair straighteners showed significant hair fiber damage and scalp skin deterioration, which worsened with repeated and prolonged application, highlighting the cytotoxic potential of these products and potential systemic risks.

research 504 Hair chemical use and systemic lupus erythematosus: a case-control study

May 2024

The researchers in this study observed that while hair chemical use was common among females with SLE, it was not linked to the development of SLE. However, those who used chemical hair straighteners before their SLE diagnosis had a higher risk of developing cutaneous manifestations.

research Hair perms/straighteners and styling agents

January 2013 in “프로그램북(구 초록집)”

This review discusses the chemical processes involved in hair styling and straightening and reports no new results; the authors highlight pregnancy safety with hair treatments during pregnancy.

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Community Join

5 / 653 results

community Finastride hair texture change is wild

in Progress Pictures 211 upvotes 1 year ago

Finasteride changed the user's hair texture from wavy to curly, reverting after stopping. Minoxidil was more effective for temple hair regrowth than finasteride.

community Extremely potent catalyst for Minoxidil

6 upvotes 6 years ago

Using Megatek with minoxidil significantly increases hair growth, especially vellus hairs, but is less effective alone. Biotin and ketoconazole shampoo are also used to support hair health.

community Looking for honest experiences with natural scalp + hair regrowth routines (no chemicals if possible)

8 months ago

The conversation discusses natural, chemical-free methods for scalp health and hair regrowth, such as using oils like rosemary, ginger, castor, and peppermint. It seeks personal experiences and effective routines for hair regrowth, especially after chemo or stress-related hair thinning.

community Chinese Research Chemicals You Suggest

in Research/Science 3 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically RU58841, with mentions of side effects from finasteride and dutasteride. Alternatives like Pyri, KX-826, and Breezula are also mentioned.

community ChatGPT might've created a new chemical (RU99999)? 😏 jk

8 upvotes 3 years ago

The conversation humorously discusses hair loss treatments, mentioning Minoxidil, finasteride, and RU58841. It jokingly suggests the creation of a new chemical called RU99999.

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Learn

8 / 801 results

learn Nanoxidil

What makes Nanoxidil different from Minoxidil for treating hair loss? Nanoxidil has a different chemical structure and may penetrate the scalp more effectively than minoxidil.

learn Hair Fibers

Can hair fibers be used along with medical treatments like minoxidil or finasteride? Yes, hair fibers can be used with minoxidil or finasteride without any chemical interaction.

learn Argan oil

Argan oil: Is it a good option if I want to avoid chemicals or medical treatments for now? Argan oil is a natural option for hair care without chemicals or medical treatments.

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

learn Verteporfin

chemical that might completely regrow follicles from hair transplant extractions

learn Dexpanthenol

precursor of vitamin B5 with hair stimulating effects

learn RU58841

Is RU58841 magic or a scam? Does it really stop baldness? RU58841 is an unapproved research chemical: the published evidence is animal and lab work from the 1990s, there has never been a controlled human trial for hair loss, and nothing sold online is quality-controlled — so its effect and its long-term safety in people are both unknown.

learn Mesotherapy

technique to inject very small amounts of beneficial chemicals into the scalp

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Clinics

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All 500 clinic results →

Experts

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Unscored
SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas