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GlossaryImmune Checkpoint Inhibitors (immune checkpoint blockade)

block proteins that prevent immune cells from attacking cancer

Immune Checkpoint Inhibitors (ICIs) are a type of cancer treatment that work by blocking proteins used by cancer cells to evade the immune system. By inhibiting these checkpoints, such as PD-1, PD-L1, and CTLA-4, ICIs enable the immune system to better recognize and attack cancer cells.

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research A Comparative Analysis of Immune Privilege in Pregnancy and Cancer in the Context of Checkpoint Blockade Immunotherapy

16 citations, March 2018 in “Seminars in Oncology”

The document concludes that pregnancy and cancer share immune evasion tactics, but more research is needed before using checkpoint blockade immunotherapy in pregnant cancer patients to avoid harm to the placenta.

research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata

60 citations, September 2015 in “Expert Review of Clinical Immunology”

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

research Cutaneous Manifestations Associated With Immune Checkpoint Inhibitors

14 citations, February 2023 in “Frontiers in immunology”

Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.

research Immune Checkpoint Inhibitor-Related Alopecia: Insight into the Pathophysiology Using Non-Invasive Diagnostic Techniques

6 citations, January 2019 in “Journal of dermatology”

Immune checkpoint inhibitors used in cancer therapy can cause hair loss, and understanding this can help manage the side effect.

research An In Situ Chemotherapy Drug Combined with Immune Checkpoint Inhibitor for Chemoimmunotherapy

1 citations, December 2023 in “Nanomaterials”

Combining specific nanoparticles with immune therapy significantly improves cancer treatment.

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community 6th Month Checkpoint! There is progress (I think?)

in Progress Pictures 29 upvotes 3 weeks ago

The conversation discusses a user's six-month progress in treating hereditary hair loss using a regimen that includes minoxidil, finasteride, dutasteride, and other medications. Opinions vary on the effectiveness and logic of the treatment, with some users suggesting additional methods like microneedling.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 3 months ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.