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GlossaryImmune Checkpoint Inhibitors (immune checkpoint blockade)

block proteins that prevent immune cells from attacking cancer

Immune Checkpoint Inhibitors (ICIs) are a type of cancer treatment that work by blocking proteins used by cancer cells to evade the immune system. By inhibiting these checkpoints, such as PD-1, PD-L1, and CTLA-4, ICIs enable the immune system to better recognize and attack cancer cells.

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research A Comparative Analysis of Immune Privilege in Pregnancy and Cancer in the Context of Checkpoint Blockade Immunotherapy

16 citations, March 2018 in “Seminars in Oncology”

The document concludes that pregnancy and cancer share immune evasion tactics, but more research is needed before using checkpoint blockade immunotherapy in pregnant cancer patients to avoid harm to the placenta.

research The Role of Lymphocytes in the Development and Treatment of Alopecia Areata

60 citations, September 2015 in “Expert Review of Clinical Immunology”

Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.

research Cutaneous Manifestations Associated With Immune Checkpoint Inhibitors

14 citations, February 2023 in “Frontiers in immunology”

Immune checkpoint inhibitors can cause skin issues but are linked to better cancer outcomes.

research Immune Checkpoint Inhibitor-Related Alopecia: Insight into the Pathophysiology Using Non-Invasive Diagnostic Techniques

6 citations, January 2019 in “Journal of dermatology”

Immune checkpoint inhibitors used in cancer therapy can cause hair loss, and understanding this can help manage the side effect.

research An In Situ Chemotherapy Drug Combined with Immune Checkpoint Inhibitor for Chemoimmunotherapy

1 citations, December 2023 in “Nanomaterials”

Combining specific nanoparticles with immune therapy significantly improves cancer treatment.

View more "checkpoint blockade" in research →

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community 6th Month Checkpoint! There is progress (I think?)

in Progress Pictures 29 upvotes 7 months ago

The conversation discusses a user's six-month progress in treating hereditary hair loss using a regimen that includes minoxidil, finasteride, dutasteride, and other medications. Opinions vary on the effectiveness and logic of the treatment, with some users suggesting additional methods like microneedling.

community Oral min 2.5mg / oral fin 1mg / 3.5 months - 25M progress

in Progress Pictures 165 upvotes 6 days ago

A 25-year-old shared progress on hair growth using oral minoxidil 2.5mg, oral finasteride 1mg, and dermarolling over 3.5 months, noting improvements and encouraging others to persist with treatments. Other users discussed their experiences with similar treatments, including topical minoxidil, ketoconazole shampoo, and tretinoin cream, with varying results and side effects.

community Dutasteride Infertility Debunked: Low T causes true infertility.

in Finasteride/Dutasteride 163 upvotes 2 months ago

Dutasteride and finasteride may temporarily affect semen quality but are unlikely to cause permanent infertility. The Kim et al. study is criticized for poor methodology, and many prefer hair retention over potential fertility concerns, using treatments like dutasteride, finasteride, and minoxidil.

community Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be careful.

in Finasteride/Dutasteride 41 upvotes 9 months ago

Dutasteride takes 1-3 months to affect scalp DHT levels, not just a week. The prostate absorbs Dutasteride faster than the scalp due to different vascular networks and enzyme densities.