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research LC/MS analysis of stratum corneum lipids: ceramide profiling and discovery

211 citations , March 2011 in “Journal of Lipid Research”

This study reports a novel LC/MS method that separates and analyzes all known ceramide subclasses in human stratum corneum, identifying a new subclass, CER [EOdS], with minimal sample preparation.

research Ceramide synthase 4 deficiency in mice causes lipid alterations in sebum and results in alopecia

67 citations , April 2014 in “Biochemical Journal”

This study found that mice deficient in ceramide synthase 4 showed altered sebum composition and progressive hair loss due to obstructed hair canals.

research Ceramide Synthase 4 Regulates Stem Cell Homeostasis and Hair Follicle Cycling

53 citations , February 2015 in “Journal of Investigative Dermatology”

This study found that inactivating CerS4 in mice led to hair follicle stem cell exhaustion and hair loss, indicating its role in regulating hair regeneration through ceramide composition and signaling pathways.

research Ceramide binding to African–American hair fibre correlates with resistance to hair breakage

45 citations , February 2002 in “International Journal of Cosmetic Science”

This study found that a ceramide derived from sphinganine can bind to African–American hair, reducing breakage when applied in a shampoo after relaxing treatments.

research Murine Epidermal Ceramide Synthase 4 Is a Key Regulator of Skin Barrier Homeostasis

15 citations , February 2020 in “Journal of Investigative Dermatology”

Ceramide Synthase 4 is crucial for healthy skin barrier function.

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learn Cetirizine

What makes cetirizine a unique anti-inflammatory option for your scalp? Laboratory work reports that cetirizine lowers PGD2 and other inflammatory mediators, which is why researchers have proposed it for the scalp. There is no approved topical product and the clinical evidence is a few small trials in pattern hair loss (none in inflammatory scalp disease), so scalp use is off-label and experimental.
How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

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community Scalp barrier integrity and its potential link to hair follicle health

in Technology 1 upvotes 5 months ago

A healthy scalp barrier is crucial for hair growth, and ceramides may play a key role in maintaining it. The conversation suggests that focusing on scalp health, alongside treatments like Minoxidil, Finasteride, and RU58841, could improve hair follicle health.

community Scalp Skin Barrier Health and Hair Follicle Cycling: A Potential Overlooked Connection

in Technology 4 months ago

The conversation discusses the importance of scalp skin barrier health in hair follicle cycling, suggesting treatments like ceramides or niacinamide to support hair growth. It also mentions the use of finasteride for hair loss.

community Scalp barrier support while using min foam? +Seb derm

in Minoxidil 1 upvotes 4 months ago

The user started using minoxidil foam daily after two years on finasteride and is managing seborrheic dermatitis with antifungal shampoo. They seek advice on moisturizing products that won't worsen their condition, with suggestions including gentle shampoos and light ceramide serums.

community Does This Product Really Contain Minoxidil? My Experience and Concerns"

1 upvotes 1 year ago

The product claims to contain Minoxidil 5%, but the ingredients list does not explicitly mention it, raising doubts about its effectiveness. The brand states that the formula includes Minoxidil's chemical components mixed with proteins and ceramides.

community Deoxyribose sugar gel worked just as well as minoxidil

in Research/Science 18 upvotes 1 year ago

A deoxyribose sugar gel may work as well as minoxidil for hair regrowth by boosting blood supply to hair follicles. Some users discuss combining it with minoxidil and cetrizine, but caution is advised due to potential risks and lack of consistent results.

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